Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma

[Display omitted] Gold NPs have great potential in biomedical applications. PAMAM dendrimers are spherical, hyper branched macromolecules which can encapsulate therapeutic molecules while stabilizing metal nanoparticle such as gold NPs. The aim of the current study was to investigate the theranostic...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 549; no. 1-2; pp. 67 - 75
Main Authors:	Alibolandi, Mona, Hoseini, Fazileh, Mohammadi, Marzieh, Ramezani, Pouria, Einafshar, Elham, Taghdisi, Seyed Mohammad, Ramezani, Mohammad, Abnous, Khalil
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 05-10-2018
Subjects:	Adenocarcinoma - drug therapy Adenocarcinoma - pathology Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Aptamers, Nucleotide - metabolism Cell Line, Tumor CHO Cells Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Colorectal cancer Cricetinae Cricetulus CT scan Curcumin Curcumin - administration & dosage Curcumin - pharmacology Dendrimers - chemistry Female Gold - chemistry Humans Metal Nanoparticles Mice Mice, Inbred BALB C Mucin-1 - metabolism Nanostructures PAMAM Polyethylene Glycols - chemistry Theranostic Theranostic Nanomedicine Tomography, X-Ray Computed - methods Curcumin CT scan Theranostic PAMAM Colorectal cancer
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Summary:	[Display omitted] Gold NPs have great potential in biomedical applications. PAMAM dendrimers are spherical, hyper branched macromolecules which can encapsulate therapeutic molecules while stabilizing metal nanoparticle such as gold NPs. The aim of the current study was to investigate the theranostic capability of curcumin-loaded dendrimer-gold hybrid structure. Dendrimer-gold hybrid structure was synthesized by complexing AuCl4− ions with PEGylated amine-terminated generation 5 poly (amidoamine) dendrimer. The resultant hybrid system was loaded with curcumin. The curcumin-loaded PEGylated Au dendrimer was further conjugated to MUC-1 aptamer in order to target the colorectal adenocarcinoma in vitro and in vivo. Obtained results demonstrated that the targeted theranostic agent was accumulated in HT29 and C26 cells in vitro and showed higher cellular cytotoxicity in comparison with non-targeted system. On the other hand, in vivo experiment demonstrated the potential of targeted theranostic system in CT-scan tumor imaging as well as cancer therapy. Findings from this study suggested that MUC-1 targeted curcumin-loaded PEGylated Au dendrimers have good X-ray attenuation and is desirable probe for CT imaging while demonstrating high therapeutic index against colorectal cancer adenocarcinoma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2018.07.052