Search Results - "Hosein, Peter J."

FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis by Suker, Mustafa, MD, Beumer, Berend R, Sadot, Eran, MD, Marthey, Lysiane, MD, Faris, Jason E, MD, Mellon, Eric A, MD, El-Rayes, Bassel F, Prof, Wang-Gillam, Andrea, MD, Lacy, Jill, Prof, Hosein, Peter J, MD, Moorcraft, Sing Yu, MD, Conroy, Thierry, Prof, Hohla, Florian, MD, Allen, Peter, MD, Taieb, Julien, Prof, Hong, Theodore S, MD, Shridhar, Ravi, MD, Chau, Ian, MD, van Eijck, Casper H, Prof, Koerkamp, Bas Groot, Dr

“…Summary Background 35% of patients with pancreatic cancer have unresectable locally advanced disease at diagnosis. Several studies have examined systemic…”
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Phase 2 study of pembrolizumab and circulating biomarkers to predict anticancer response in advanced, unresectable hepatocellular carcinoma by Feun, Lynn G., Li, Ying‐Ying, Wu, Chunjing, Wangpaichitr, Medhi, Jones, Patricia D., Richman, Stephen P., Madrazo, Beatrice, Kwon, Deukwoo, Garcia‐Buitrago, Monica, Martin, Paul, Hosein, Peter J., Savaraj, Niramol

“…Background Checkpoint inhibitors have shown modest activity in patients with advanced hepatocellular carcinoma (HCC). Herein, the authors report a prospective…”
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Percutaneous Irreversible Electroporation for Downstaging and Control of Unresectable Pancreatic Adenocarcinoma by Narayanan, Govindarajan, MD, Hosein, Peter J., MD, Arora, Geetika, MD, Barbery, Katuzka J., MD, Froud, Tatiana, MD, Livingstone, Alan S., MD, Franceschi, Dido, MD, Rocha Lima, Caio M., MD, Yrizarry, Jose, MD

“…Abstract Purpose Treatment of unresectable locally advanced pancreatic cancer (LAPC) usually includes chemotherapy and/or radiation therapy in an attempt to…”
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A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma by Hosein, Peter J, Macintyre, Jessica, Kawamura, Carolina, Maldonado, Jennifer Cudris, Ernani, Vinicius, Loaiza-Bonilla, Arturo, Narayanan, Govindarajan, Ribeiro, Afonso, Portelance, Lorraine, Merchan, Jaime R, Levi, Joe U, Rocha-Lima, Caio M

“…5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good…”
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Percutaneous Image-Guided Irreversible Electroporation for the Treatment of Unresectable, Locally Advanced Pancreatic Adenocarcinoma by Narayanan, Govindarajan, MD, Hosein, Peter J., MD, Beulaygue, Isabelle C., PhD, Froud, Tatiana, MD, Scheffer, Hester J., MD, Venkat, Shree R., MD, Echenique, Ana M., MD, Hevert, Elizabeth C., MD, Livingstone, Alan S., MD, Rocha-Lima, Caio M., MD, Merchan, Jaime R., MD, Levi, Joseph U., MD, Yrizarry, Jose M., MD, Lencioni, Riccardo, MD

“…Abstract Purpose To describe safety and effectiveness of percutaneous irreversible electroporation (IRE) for treatment of unresectable, locally advanced…”
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Transmembrane TNF-TNFR2 signaling as a critical immunoregulatory node in pancreatic cancer by Dickey, Erin M, Bianchi, Anna, Amirian, Haleh, Hosein, Peter J, Faustman, Denise, Brambilla, Roberta, Datta, Jashodeep

“…Pancreatic cancer is characterized by extreme therapeutic resistance. In pancreatic cancers harboring high-risk genomes, we describe that cancer…”
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Long-term outcome of patients undergoing liver transplantation for mixed hepatocellular carcinoma and cholangiocarcinoma: an analysis of the UNOS database by Vilchez, Valery, Shah, Malay B, Daily, Michael F, Pena, Luis, Tzeng, Ching-Wei D, Davenport, Daniel, Hosein, Peter J, Gedaly, Roberto, Maynard, Erin

“…Abstract Background Mixed hepatocellular and cholangiocarcinoma (HCC-CC) have been associated with a poor prognosis after liver transplantation (LT). We aimed…”
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Multicenter randomized controlled trial and registry study to assess the safety and efficacy of the NanoKnife® system for the ablation of stage 3 pancreatic adenocarcinoma: overview of study protocols by Narayanan, Govindarajan, Bilimoria, Malcolm M, Hosein, Peter J, Su, Zhaohui, Mortimer, Kathleen M, Martin, Robert C. G

“…Abstract Background Irreversible electroporation (IRE) is a local ablation technique utilizing high voltage, low energy direct current to create nanopores in…”
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A multicentre study of primary breast diffuse large B‐cell lymphoma in the rituximab era by Hosein, Peter J., Maragulia, Jocelyn C., Salzberg, Matthew P., Press, Oliver W., Habermann, Thomas M., Vose, Julie M., Bast, Martin, Advani, Ranjana H., Tibshirani, Robert, Evens, Andrew M., Islam, Nahida, Leonard, John P., Martin, Peter, Zelenetz, Andrew D., Lossos, Izidore S.

“…Summary Primary breast diffuse large B‐cell lymphoma (DLBCL) is a rare subtype of non‐Hodgkin lymphoma (NHL) with limited data on pathology and outcome. A…”
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Percutaneous Irreversible Electroporation for the Treatment of Colorectal Cancer Liver Metastases with a Proposal for a New Response Evaluation System by Hosein, Peter J., MD, Echenique, Ana, MD, Loaiza-Bonilla, Arturo, MD, Froud, Tatiana, MD, Barbery, Katuzka, MD, Rocha Lima, Caio M., MD, Yrizarry, Jose M., MD, Narayanan, Govindarajan, MD

“…Abstract Purpose To describe an initial experience with irreversible electroporation (IRE) in patients with colorectal liver metastasis (CLM). Materials and…”
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Effect of Complications on Oncologic Outcomes after Pancreaticoduodenectomy for Pancreatic Cancer by Le, Anh-Thu, MD, Huang, Bin, DrPH, Hnoosh, Dima, MD, Saeed, Hayder, MD, Dineen, Sean P., MD, Hosein, Peter J., MD, Durbin, Eric B., DrPH, Kudrimoti, Mahesh, MD, McGrath, Patrick C., MD, Tzeng, Ching-Wei D., MD

“…ABSTRACT Background While adjuvant therapy (AT) is a necessary component of multimodality therapy for pancreatic adenocarcinoma (PDAC), its application can be…”
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Does Neoadjuvant Chemotherapy Change the Role of Regional Lymphadenectomy in Pancreatic Cancer Survival? by Macedo, Francis Igor, Picado, Omar, Hosein, Peter J, Dudeja, Vikas, Franceschi, Dido, Mesquita-Neto, Jose Wilson, Yakoub, Danny, Merchant, Nipun B

“…The objective of this study was to evaluate the role of lymph node (LN) dissection and staging in outcomes of patients with pancreatic adenocarcinoma (PDAC)…”
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Comprehensive genomic profiling in routine clinical practice leads to a low rate of benefit from genotype-directed therapy by Hilal, Talal, Nakazawa, Mary, Hodskins, Jacob, Villano, John L, Mathew, Aju, Goel, Guarav, Wagner, Lars, Arnold, Susanne M, DeSimone, Philip, Anthony, Lowell B, Hosein, Peter J

“…Describe a single-center real-world experience with comprehensive genomic profiling (CGP) to identify genotype directed therapy (GDT) options for patients with…”
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Phase II clinical trial of nab‐paclitaxel plus cisplatin plus gemcitabine (NABPLAGEM) in patients with untreated advanced pancreatic cancer by Jameson, Gayle S., Hosein, Peter J., Pierce, Erin, Kamgar, Mandana, Gordon, Michael S., Snyder, Courtney, Roe, Denise J., Wertheim, Betsy C., Davey, Marina, Barrett, Michael T., Von Hoff, Daniel D., Borazanci, Erkut

“…Background A previous phase IB/II study of nab‐paclitaxel + cisplatin + gemcitabine (NABPLAGEM) in 25 patients with previously untreated metastatic pancreatic…”
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Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma by Islam, Md Obaidul, Thangaretnam, Krishnapriya, Lu, Heng, Peng, Dunfa, Soutto, Mohammed, El-Rifai, Wael, Giordano, Silvia, Ban, Yuguang, Chen, Xi, Bilbao, Daniel, Villarino, Alejandro V., Schürer, Stephan, Hosein, Peter J., Chen, Zheng

“…Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for…”
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Cancer Stem Cell Marker Expression Alone and in Combination with Microvascular Invasion Predicts Poor Prognosis in Patients Undergoing Transplantation For Hepatocellular Carcinoma by Vilchez, Valery, MD, Turcios, Lilia, PhD, Zaytseva, Yekaterina, PhD, Stewart, Rachel, DO, Lee, Eun Y., MD, Maynard, Erin, MD, Shah, Malay B., MD, Daily, Michael F., MD, Tzeng, Ching-Wei D., MD, Davenport, Daniel, PhD, Castellanos, Ana Lia, MD, Krohmer, Steven, MD, Hosein, Peter J., MD, Evers, B. Mark, MD, Gedaly, Roberto, MD

“…Abstract Background The Cancer Stem Cell hypothesis provides an explanation for Hepatocellular Carcinoma (HCC) heterogeneity. We investigated the expression of…”
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Complete response to ipilimumab and nivolumab therapy in a patient with extensive extrapulmonary high-grade small cell carcinoma of the pancreas and HIV infection by Husnain, Muhammad, Park, Wungki, Ramos, Juan Carlos, Johnson, Thomas E, Chan, Joseph, Dasari, Arvind, Mudad, Raja, Hosein, Peter J

“…Immune checkpoint inhibitors (CPIs) have shown promising results in many solid tumors. There are limited data on the safety and efficacy of these drugs in HIV…”
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Percutaneous Approach to Irreversible Electroporation of the Pancreas: Miami Protocol by Venkat, Shree, MD, Hosein, Peter J., MD, Narayanan, Govindarajan, MD

“…Despite advances in the treatment of unresectable locally advanced pancreatic cancer, outcomes remain poor. Irreversible electroporation is a nonthermal…”
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A multicenter phase II study of darinaparsin in relapsed or refractory Hodgkin's and non-Hodgkin's lymphoma by Hosein, Peter J., Craig, Michael D., Tallman, Martin S., Boccia, Ralph V., Hamilton, Brian L., Lewis, Jonathan J., Lossos, Izidore S.

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Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer by Datta, Jashodeep, Dai, Xizi, Bianchi, Anna, De Castro Silva, Iago, Mehra, Siddharth, Garrido, Vanessa T., Lamichhane, Purushottam, Singh, Samara P., Zhou, Zhiqun, Dosch, Austin R., Messaggio, Fanuel, Ban, Yuguang, Umland, Oliver, Hosein, Peter J., Nagathihalli, Nagaraj S., Merchant, Nipun B.

“…We have shown that reciprocally activated rat sarcoma (RAS)/mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK) and Janus…”
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