Search Results - "Hosein, Abdel Nasser"

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration by Luga, Valbona, Zhang, Liang, Viloria-Petit, Alicia M., Ogunjimi, Abiodun A., Inanlou, Mohammad R., Chiu, Elaine, Buchanan, Marguerite, Hosein, Abdel Nasser, Basik, Mark, Wrana, Jeffrey L.

“…Stroma in the tumor microenvironment plays a critical role in cancer progression, but how it promotes metastasis is poorly understood. Exosomes are small…”
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Translational advances in pancreatic ductal adenocarcinoma therapy by Hosein, Abdel Nasser, Dougan, Stephanie K, Aguirre, Andrew J, Maitra, Anirban

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is most frequently detected at advanced stages, limiting treatment options to systemic…”
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Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution by Hosein, Abdel Nasser, Huang, Huocong, Wang, Zhaoning, Parmar, Kamalpreet, Du, Wenting, Huang, Jonathan, Maitra, Anirban, Olson, Eric, Verma, Udit, Brekken, Rolf A

“…Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death with limited therapeutic options available. This highlights the need for…”
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Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications by Hosein, Abdel Nasser, Beg, Muhammad Shaalan

“…Purpose of Review Pancreatic adenocarcinoma is a leading cause of cancer mortality in western countries with a uniformly poor prognosis. Unfortunately, there…”
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Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer by Huang, Huocong, Zhang, Yuqing, Gallegos, Valerie, Sorrelle, Noah, Zaid, Mohamed Medhat, Toombs, Jason, Du, Wenting, Wright, Steven, Hagopian, Moriah, Wang, Zhaoning, Hosein, Abdel Nasser, Sathe, Adwait Amod, Xing, Chao, Koay, Eugene J, Driscoll, Kyla E, Brekken, Rolf A

“…TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell…”
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Breast Carcinoma―Associated Fibroblasts Rarely Contain p53 Mutations or Chromosomal Aberrations by ABDEL NASSER HOSEIN, MIN WU, ARCAND, Suzanna L, LAVALLEE, Sylvie, HEBERT, Josée, TONIN, Patricia N, BASIK, Mark

“…It has become increasingly clear that the cells within the tumor microenvironment play a critical role in cancer growth and metastasis. Studies in experimental…”
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Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma by Hosein, Abdel Nasser, Dangol, Gita, Okumura, Takashi, Roszik, Jason, Rajapakshe, Kimal, Siemann, Megan, Zaid, Mohamed, Ghosh, Bidyut, Monberg, Maria, Guerrero, Paola A., Singhi, Aatur, Haymaker, Cara L., Clevers, Hans, Abou-Elkacem, Lotfi, Woermann, Sonja M., Maitra, Anirban

“…RNF43 is an E3 ubiquitin ligase that is recurrently mutated in pancreatic ductal adenocarcinoma (PDAC) and precursor cystic neoplasms of the pancreas. The…”
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Loss of Rnf43 to accelerate KRAS-mediated neoplasia in a clinically relevant genetically engineered mouse model of pancreatic adenocarcinoma by Hosein, Abdel Nasser, Dangol, Gita, Okumura, Takashi, Abou-Elkacem, Lotfi, Maitra, Anirban

“…Abstract only 733 Background: The genetic heterogeneity of pancreatic ductal adenocarcinoma (PDAC) demands a personalized molecular-targeted treatment…”
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The effect of valproic acid in combination with irradiation and temozolomide on primary human glioblastoma cells by Hosein, Abdel Nasser, Lim, Yi Chieh, Day, Bryan, Stringer, Brett, Rose, Stephen, Head, Richard, Cosgrove, Leah, Sminia, Peter, Fay, Michael, Martin, Jennifer H.

“…Glioblastoma multiforme (GBM) has nearly uniformly fatal with a median survival of less than 2 years. While there have not been any novel anti-GBM therapeutics…”
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Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution by Hosein, Abdel Nasser, Huang, Huocong, Wang, Zhaoning, Parmar, Kamalpreet, Du, Wenting, Huang, Jonathan, Maitra, Anirban, Olson, Eric, Verma, Udit, Brekken, Rolf A.

“…Abstract only e15739 Background: Pancreatic ductal adenocarcinoma (PDA) is a major cause of cancer-related death with limited therapeutic options available…”
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A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer by Hosein, Abdel Nasser, Livingstone, Julie, Buchanan, Marguerite, Reid, James F, Hallett, Michael, Basik, Mark

“…Cancer-associated fibroblasts (CAFs) play an important role in breast cancer pathogenesis by paracrine regulation of breast cancer cell biology. Several in…”
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Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP–CGH analysis by Hosein, Abdel Nasser, Song, Sarah, McCart Reed, Amy E, Jayanthan, Janani, Reid, Lynne E, Kutasovic, Jamie R, Cummings, Margaret C, Waddell, Nic, Lakhani, Sunil R, Chenevix-Trench, Georgia, Simpson, Peter T

“…Pathology archives contain vast resources of clinical material in the form of formalin-fixed paraffin-embedded (FFPE) tissue samples. Owing to the methods of…”
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Fundamental Investigations into Breast Carcinoma-Associated Fibroblasts by Hosein, Abdel Nasser

“…Breast cancer stroma is a heterogenous mixture of cells types which, in addition to the carcinomatous epithelium itself, consists predominately of endothelium,…”
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