Search Results - "Horwitz, Susan B"

Structural Basis of Microtubule Stabilization by Discodermolide by Prota, Andrea E., Bargsten, Katja, Redondo‐Horcajo, Mariano, Smith, Amos B., Yang, Chia‐Ping H., McDaid, Hayley M., Paterson, Ian, Horwitz, Susan B., Fernando Díaz, José, Steinmetz, Michel O.

“…Microtubule‐stabilizing agents (MSAs) are widely used in chemotherapy. Using X‐ray crystallography we elucidated the detailed binding modes of two potent MSAs,…”
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Activation of the Steroid and Xenobiotic Receptor (Human Pregnane X Receptor) by Nontaxane Microtubule-Stabilizing Agents by Mani, Sridhar, Huang, Haiyan, Sundarababu, Sumathy, Liu, Wenjing, Kalpana, Ganjam, Smith, Amos B, Horwitz, Susan B

“…Purpose: Because induction of drug efflux transporters is one of the major underlying mechanisms of drug resistance in cancer chemotherapy, and human pregnane…”
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Highly Concise Routes to Epothilones:  The Total Synthesis and Evaluation of Epothilone 490 by Biswas, Kaustav, Lin, Hong, Njardarson, Jon T, Chappell, Mark D, Chou, Ting-Chao, Guan, Yongbiao, Tong, William P, He, Lifeng, Horwitz, Susan B, Danishefsky, Samuel J

“…A concise modular laboratory construction of the epothilone class of promising antitumor agents has been accomplished. For the first time in the epothilone…”
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The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: A First in Class Epothilone B Analogue in Late-Phase Clinical Development by Goel, Sanjay, Cohen, Marvin, Cömezoglu, S Nilgün, Perrin, Lionel, André, François, Jayabalan, David, Iacono, Lisa, Comprelli, Adriana, Ly, Van T, Zhang, Donglu, Xu, Carrie, Humphreys, W Griffith, McDaid, Hayley, Goldberg, Gary, Horwitz, Susan B, Mani, Sridhar

“…Purpose: To determine if ixabepilone is a substrate for cytochrome P450 3A4 (CYP3A4) and if its metabolism by this cytochrome is clinically important, we did a…”
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Remote Effects in Macrolide Formation through Ring-Forming Olefin Metathesis:  An Application to the Synthesis of Fully Active Epothilone Congeners by Meng, Dongfang, Su, Dai-Shi, Balog, Aaron, Bertinato, Peter, Sorensen, Erik J, Danishefsky, Samuel J, Zheng, Yu-Huang, Chou, Ting-Chao, He, Lifeng, Horwitz, Susan B

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Design, Synthesis, and Biological Evaluation of New-Generation Taxoids by Ojima, Iwao, Chen, Jin, Sun, Liang, Borella, Christopher P, Wang, Tao, Miller, Michael L, Lin, Songnian, Geng, Xudong, Kuznetsova, Larisa, Qu, Chuanxing, Gallager, David, Zhao, Xianrui, Zanardi, Ilaria, Xia, Shujun, Horwitz, Susan B, Mallen-St. Clair, Jon, Guerriero, Jennifer L, Bar-Sagi, Dafna, Veith, Jean M, Pera, Paula, Bernacki, Ralph J

“…Novel second-generation taxoids with systematic modifications at the C2, C10, and C3′N positions were synthesized and their structure−activity relationships…”
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Synthesis and biological evaluation of novel 3′-difluorovinyl taxoids by Kuznetsova, Larissa, Sun, Liang, Chen, Jin, Zhao, Xianrui, Seitz, Joshua, Das, Manisha, Li, Yuan, Veith, Jean M., Pera, Paula, Bernacki, Ralph J., Xia, Shujun, Horwitz, Susan B., Ojima, Iwao

“…Novel 3′-difluorovinyl taxoids were synthesized and evaluated for their in vitro cytotoxicities against human breast, ovarian, colon and pancreatic cancer cell…”
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Multiple microtubule alterations are associated with Vinca alkaloid resistance in human leukemia cells by KAVALLARIS, Maria, TAIT, A. Sasha, WALSH, Bradley J, LIFENG HE, HORWITZ, Susan B, NORRIS, Murray D, HABER, Michelle

“…Vinca alkaloids are used extensively in the treatment of childhood acute lymphoblastic leukemia (ALL) and despite their usefulness, drug resistance remains a…”
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Design, Synthesis, and Biological Evaluation of Novel C14−C3′BzN-Linked Macrocyclic Taxoids by Sun, Liang, Geng, Xudong, Geney, Raphaël, Li, Yuan, Simmerling, Carlos, Li, Zhong, Lauher, Joseph W, Xia, Shujun, Horwitz, Susan B, Veith, Jean M, Pera, Paula, Bernacki, Ralph J, Ojima, Iwao

“…Novel macrocyclic paclitaxel congeners were designed to mimic the bioactive conformation of paclitaxel. Computational analysis of the “REDOR-Taxol” structure…”
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Promotion of microtubule assembly in vitro by taxol by SCHIFF, PETER B, FANT, JANE, HORWITZ, SUSAN B

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Design, Synthesis, and Biological Evaluation of Novel C14-C3'BzN-Linked Macrocyclic Taxoids by LIANG SUN, XUDONG GENG, PERA, Paula, BEMACKI, Ralph J, OJIMA, Iwao, GENEY, Raphaël, YUAN LI, SIMMERLING, Carlos, ZHONG LI, LAUHER, Joseph W, SHUJUN XIA, HORWITZ, Susan B, VEITH, Jean M

“…Novel macrocyclic paclitaxel congeners were designed to mimic the bioactive conformation of paclitaxel. Computational analysis of the "REDOR-Taxol" structure…”
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Use of the Tubulin Bound Paclitaxel Conformation for Structure-Based Rational Drug Design by Geney, Raphaël, Sun, Liang, Pera, Paula, Bernacki, Ralph J., Xia, Shujun, Horwitz, Susan B., Simmerling, Carlos L., Ojima, Iwao

“…A new computational docking protocol has been developed and used in combination with conformational information inferred from REDOR-NMR experiments on…”
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Properties and products of the degradation of DNA by bleomycin and iron(II) by Sausville, Edward A, Stein, Roland W, Peisach, Jack, Horwitz, Susan B

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Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells by Loike, John D, Horwitz, Susan B

“…The effect of VP-16-213 on cellular DNA was studied by following the sedimentation profiles of radioactive DNA in HeLa cells on alkaline sucrose gradients. In…”
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Effects of podophyllotoxin and VP-16-213 on microtubule assembly in vitro and nucleoside transport in HeLa cells by Loike, John D, Horwitz, Susan B

“…VP-16-213, a semisynthetic derivative of podophyllotoxin, is an active antitumor agent. In this paper, the effects of VP-16-213 and podophyllotoxin on…”
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Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations by Swindell, Charles S, Krauss, Nancy E, Horwitz, Susan B, Ringel, Israel

“…Taxol, a potent inhibitor of cell replication, enhances the assembly of tubulin into stable microtubules and promotes the formation of microtubule bundles in…”
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Bleomycin-DNA interactions: fluorescence and proton magnetic resonance studies by Chien, Mingjien, Grollman, Arthur P, Horwitz, Susan B

“…The interaction of bleomycin A2 with DNA has been examined by fluorescence spectroscopy and proton magnetic resonance techniques. Fluorescence bands observed…”
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On the Total Synthesis and Preliminary Biological Evaluations of 15(R) and 15(S) Aza-dEpoB:  A Mitsunobu Inversion at C15 in Pre-Epothilone Fragments by Stachel, Shawn J, Chappell, Mark D, Lee, Chul Bom, Danishefsky, Samuel J, Chou, Ting-Chao, He, Lifeng, Horwitz, Susan B

“…The syntheses of two epothilone analogues, 15(S)-aza-12,13-desoxyepothilone B and the epimeric 15(R)-aza-12,13-desoxyepothilone B, are described. A Mitsunobu…”
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A New Paclitaxel Photoaffinity Analog with a 3-(4-Benzoylphenyl)propanoyl Probe for Characterization of Drug-Binding Sites on Tubulin and P-Glycoprotein by Ojima, Iwao, Duclos, Olivier, Dorman, Gyorgy, Simonot, Bruno, Prestwich, Glenn D, Rao, Srinivasa, Lerro, Keith A, Horwitz, Susan B

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Taxol in ovarian cancer by Runowicz, C D, Wiernik, P H, Einzig, A I, Goldberg, G L, Horwitz, S B

“…Taxol is a structurally complex natural plant product with a novel mechanism of action. The supply of this drug is limited by its low abundance in the bark of…”
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