Search Results - "Horwitz, M."

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span by Grunewald, M., Kumar, S., Sharife, H., Volinsky, E., Gileles-Hillel, A., Licht, T., Permyakova, A., Hinden, L., Azar, S., Friedmann, Y., Kupetz, P., Tzuberi, R., Anisimov, A., Alitalo, K., Horwitz, M., Leebhoff, S., Khoma, O. Z., Hlushchuk, R., Djonov, V., Abramovitch, R., Tam, J., Keshet, E.

“…More VEGF, more life—and health span Advanced aging is celebrated but its ill effects, deterioration at the cell, tissue, and organ levels, are not. Grunewald…”
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Challenges in Clinical Development of Mesenchymal Stromal/Stem Cells: Concise Review by Mastrolia, Ilenia, Foppiani, Elisabetta Manuela, Murgia, Alba, Candini, Olivia, Samarelli, Anna Valeria, Grisendi, Giulia, Veronesi, Elena, Horwitz, Edwin M., Dominici, Massimo

“…Summary Identified 50 years ago, mesenchymal stromal/stem cells (MSCs) immediately generated a substantial interest among the scientific community because of…”
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Randomized Trial of Hypofractionated External-Beam Radiotherapy for Prostate Cancer by POLLACK, Alan, WALKER, Gail, MA, Charlie, BUYYOUNOUSKI, Mark K, HORWITZ, Eric M, PRICE, Robert, FEIGENBERG, Steven, KONSKI, Andre A, STOYANOVA, Radka, MOVSAS, Benjamin, GREENBERG, Richard E, UZZO, Robert G

“…To determine if escalated radiation dose using hypofractionation significantly reduces biochemical and/or clinical disease failure (BCDF) in men treated…”
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Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study by Khodadoust, Michael S, Rook, Alain H, Porcu, Pierluigi, Foss, Francine, Moskowitz, Alison J, Shustov, Andrei, Shanbhag, Satish, Sokol, Lubomir, Fling, Steven P, Ramchurren, Nirasha, Pierce, Robert, Davis, Asa, Shine, Richard, Li, Shufeng, Fong, Sophia, Kim, Jinah, Yang, Yi, Blumenschein, Wendy M, Yearley, Jennifer H, Das, Biswajit, Patidar, Rajesh, Datta, Vivekananda, Cantu, Erin, McCutcheon, Justine N, Karlovich, Chris, Williams, P Mickey, Subrahmanyam, Priyanka B, Maecker, Holden T, Horwitz, Steven M, Sharon, Elad, Kohrt, Holbrook E, Cheever, Martin A, Kim, Youn H

“…To assess the efficacy of pembrolizumab in patients with advanced relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS). CITN-10 is a…”
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Few and far between: clinical management of rare extranodal subtypes of mature T-cell and NK-cell lymphomas by Stuver, Robert, Epstein-Peterson, Zachary D, Horwitz, Steven M

“…While all peripheral T-cell lymphomas are uncommon, certain subtypes are truly rare, with less than a few hundred cases per year in the USA. There are often no…”
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Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial by Prince, H Miles, Prof, Kim, Youn H, Prof, Horwitz, Steven M, MD, Dummer, Reinhard, Prof, Scarisbrick, Julia, MD, Quaglino, Pietro, Prof, Zinzani, Pier Luigi, Prof, Wolter, Pascal, MD, Sanches, Jose A, PhD, Ortiz-Romero, Pablo L, Prof, Akilov, Oleg E, MD, Geskin, Larisa, MD, Trotman, Judith, MD, Taylor, Kerry, MBBS, Dalle, Stephane, Prof, Weichenthal, Michael, Prof, Walewski, Jan, Prof, Fisher, David, MD, Dréno, Brigitte, Prof, Stadler, Rudolf, Prof, Feldman, Tatyana, MD, Kuzel, Timothy M, Prof, Wang, Yinghui, MS, Palanca-Wessels, Maria Corinna, MD, Zagadailov, Erin, PharmD, Trepicchio, William L, PhD, Zhang, Wenwen, PhD, Lin, Hui-Min, PhD, Liu, Yi, PhD, Huebner, Dirk, MD, Little, Meredith, MPH, Whittaker, Sean, Prof, Duvic, Madeleine, Prof

“…Summary Background Cutaneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life. Present systemic therapies rarely…”
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The outcome of peripheral T-cell lymphoma patients failing first-line therapy: a report from the prospective, International T-Cell Project by Bellei, Monica, Foss, Francine M, Shustov, Andrei R, Horwitz, Steven M, Marcheselli, Luigi, Kim, Won Seog, Cabrera, Maria E, Dlouhy, Ivan, Nagler, Arnon, Advani, Ranjana H, Pesce, Emanuela A, Ko, Young-Hyeh, Martinez, Virginia, Montoto, Silvia, Chiattone, Carlos, Moskowitz, Alison, Spina, Michele, Biasoli, Irene, Manni, Martina, Federico, Massimo

“…This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective…”
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The evolution of brachytherapy for prostate cancer by Zaorsky, Nicholas G., Davis, Brian J., Nguyen, Paul L., Showalter, Timothy N., Hoskin, Peter J., Yoshioka, Yasuo, Morton, Gerard C., Horwitz, Eric M.

“…Key Points Brachytherapy and brachytherapy boost with low-dose-rate brachytherapy (LDR-BT) or high-dose-rate (HDR)-BT can be used as first-line therapies in…”
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Multicenter analysis of outcomes in blastic plasmacytoid dendritic cell neoplasm offers a pretargeted therapy benchmark by Taylor, Justin, Haddadin, Michael, Upadhyay, Vivek A., Grussie, Erwin, Mehta-Shah, Neha, Brunner, Andrew M., Louissaint, Abner, Lovitch, Scott B., Dogan, Ahmet, Fathi, Amir T., Stone, Richard M., Tallman, Martin S., Rampal, Raajit K., Neuberg, Donna S., Stevenson, Kristen E., Horwitz, Steven M., Lane, Andrew A.

“…Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon hematologic malignancy with poor outcomes. Existing data on the clinical behavior of BPDCN…”
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The rise and fall of prostate brachytherapy: Use of brachytherapy for the treatment of localized prostate cancer in the National Cancer Data Base by Martin, Jeffrey M., Handorf, Elizabeth A., Kutikov, Alexander, Uzzo, Robert G., Bekelman, Justin E., Horwitz, Eric M., Smaldone, Marc C.

“…BACKGROUND Brachytherapy has been shown to be an efficacious and cost‐effective treatment among patients with localized prostate cancer. In this study, the…”
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Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning by Olson, Timothy S., Caselli, Anna, Otsuru, Satoru, Hofmann, Ted J., Williams, Richard, Paolucci, Paolo, Dominici, Massimo, Horwitz, Edwin M.

“…Successful hematopoietic stem cell (HSC) transplantation requires donor HSC engraftment within specialized bone marrow microenvironments known as HSC niches…”
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Key Metabolic Pathways in MSC-Mediated Immunomodulation: Implications for the Prophylaxis and Treatment of Graft Versus Host Disease by Burnham, Andre J, Foppiani, Elisabetta Manuela, Horwitz, Edwin M

“…Mesenchymal stromal cells (MSCs) are spindle-shaped, plastic-adherent cells with potent immunosuppressive activity both and . MSCs have been employed as a…”
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Phase II Study of Bendamustine in Relapsed and Refractory Hodgkin Lymphoma by MOSKOWITZ, Alison J, HAMLIN, Paul A, GRAUSTEIN, Tricia, ZELENETZ, Andrew D, MOSKOWITZ, Craig H, PERALES, Miguel-Angel, GERECITANO, John, HORWITZ, Steven M, MATASAR, Matthew J, NOY, Ariela, LIA PALOMBA, Maria, PORTLOCK, Carol S, STRAUS, David J

“…Limited data exist regarding the activity of bendamustine in Hodgkin lymphoma (HL). This phase II study evaluated the efficacy of bendamustine in relapsed and…”
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Contemporary use trends and survival outcomes in patients undergoing radical cystectomy or bladder‐preservation therapy for muscle‐invasive bladder cancer by Cahn, David B., Handorf, Elizabeth A., Ghiraldi, Eric M., Ristau, Benjamin T., Geynisman, Daniel M., Churilla, Thomas M., Horwitz, Eric M., Sobczak, Mark L., Chen, David Y. T., Viterbo, Rosalia, Greenberg, Richard E., Kutikov, Alexander, Uzzo, Robert G., Smaldone, Marc C.

“…BACKGROUND The current study was performed to examine temporal trends and compare overall survival (OS) in patients undergoing radical cystectomy (RC) or…”
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Mogamulizumab versus investigator's choice of chemotherapy regimen in relapsed/refractory adult T-cell leukemia/lymphoma by Phillips, Adrienne A, Fields, Paul A, Hermine, Olivier, Ramos, Juan C, Beltran, Brady E, Pereira, Juliana, Wandroo, Farooq, Feldman, Tatyana, Taylor, Graham P, Sawas, Ahmed, Humphrey, Jeffrey, Kurman, Michael, Moriya, Junji, Dwyer, Karen, Leoni, Mollie, Conlon, Kevin, Cook, Lucy, Gonsky, Jason, Horwitz, Steven M

“…Mogamulizumab, a humanized defucosylated anti-C-C chemokine receptor 4 monoclonal antibody, has been approved in Japan for the treatment of C-C chemokine…”
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Ten-Year Follow-Up of Radiation Therapy Oncology Group Protocol 92-02: A Phase III Trial of the Duration of Elective Androgen Deprivation in Locally Advanced Prostate Cancer by HORWITZ, Eric M, BAE, Kyounghwa, SHIPLEY, William U, HANKS, Gerald E, PORTER, Arthur, GRIGNON, David J, BRERETON, Harmar D, VENKATESAN, Varagur, LAWTON, Colleen A, ROSENTHAL, Seth A, SANDIER, Howard M

“…To determine whether adding 2 years of androgen-deprivation therapy (ADT) improved outcome for patients electively treated with ADT before and during radiation…”
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Isolated Allogeneic Bone Marrow-Derived Mesenchymal Cells Engraft and Stimulate Growth in Children with Osteogenesis Imperfecta: Implications for Cell Therapy of Bone by Horwitz, Edwin M., Gordon, Patricia L., Winston K. K. Koo, Marx, Jeffrey C., Neel, Michael D., McNall, Rene Y., Muul, Linda, Hofmann, Ted

“…Treatment with isolated allogeneic mesenchymal cells has the potential to enhance the therapeutic effects of conventional bone marrow transplantation in…”
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Tendon Progenitor Cells in Injured Tendons Have Strong Chondrogenic Potential: The CD105‐Negative Subpopulation Induces Chondrogenic Degeneration by Asai, Shuji, Otsuru, Satoru, Candela, Maria Elena, Cantley, Leslie, Uchibe, Kenta, Hofmann, Ted J., Zhang, Kairui, Wapner, Keith L., Soslowsky, Louis J., Horwitz, Edwin M., Enomoto-Iwamoto, Motomi

“…To study the cellular mechanism of the tendon repair process, we used a mouse Achilles tendon injury model to focus on the cells recruited to the injured site…”
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What Are Medical Students in the United States Learning About Radiation Oncology? Results of a Multi-Institutional Survey by Zaorsky, Nicholas G., MD, Shaikh, Talha, MD, Handorf, Elizabeth, PhD, Eastwick, Gary, MD, Hesney, Adam, MD, Scher, Eli D., DO, Jones, Ryan T., MD, Showalter, Timothy N., MD, Avkshtol, Vladimir, MD, Rice, Stephanie R., MD, Horwitz, Eric M., MD, Meyer, Joshua E., MD

“…Purpose The purposes of this study were to assess the exposure that medical students (MSs) have to radiation oncology (RO) during the course of their medical…”
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Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs by Martinez, Caridad, Hofmann, Ted J., Marino, Roberta, Dominici, Massimo, Horwitz, Edwin M.

“…Mesenchymal stromal cells (MSCs) have enormous potential for the regeneration of bone, cartilage, and other tissues derived from primitive mesoderm. Despite…”
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