Search Results - "Horwitz, AH"

Escherichia coli Secretion of an Active Chimeric Antibody Fragment by Better, Marc, Chang, C. Paul, Robinson, Randy R., Horwitz, Arnold H.

“…A chimeric mouse-human Fab protein that binds specifically to the human carcinoma cell line C3347 has been expressed and secreted from Escherichia coli. This…”
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In Vitro and In Vivo Pharmacology and Pharmacokinetics of a Human Engineered™ Monoclonal Antibody to Epithelial Cell Adhesion Molecule by Ammons, W. Steve, Bauer, Robert J., Horwitz, Arnold H., Chen, Zhi J., Bautista, Eddie, Ruan, Harry H., Abramova, Marina, Scott, Kristen R., Dedrick, Russell L.

“…ING-1(heMAb), a Human Engineered™ monoclonal antibody to epithelial cell adhesion molecule (Ep-CAM ), was evaluated for its in vitro and in vivo activity. The…”
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Biochemical characterization of recombinant fusions of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein. Implications in biological activity by Abrahamson, S L, Wu, H M, Williams, R E, Der, K, Ottah, N, Little, R, Gazzano-Santoro, H, Theofan, G, Bauer, R, Leigh, S, Orme, A, Horwitz, A H, Carroll, S F, Dedrick, R L

“…The physiological response to endotoxin (lipopolysaccharide (LPS)) can be regulated by two closely related LPS-binding proteins, LPS-binding protein (LBP),…”
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Bactericidal/permeability-increasing protein inhibits growth of a strain of Acholeplasma laidlawii and L forms of the Gram-positive bacteria Staphylococcus aureus and Streptococcus pyogenes by HORWITZ, A. H, WILLIAMS, R. E, LIU, P.-S, NADELL, R

“…Bactericidal/permeability-increasing protein (BPI) inhibited growth of cell wall-deficient Acholeplasma laidlawii and L forms of certain strains of…”
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An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity by Theofan, G, Horwitz, AH, Williams, RE, Liu, PS, Chan, I, Birr, C, Carroll, SF, Meszaros, K, Parent, JB, Kasler, H

“…LPS-binding protein (LBP) mediates the pro-inflammatory effects of bacterial LPS by enhancing LPS-induced cytokine production by monocytic cells. LBP binds…”
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Expression and Characterization of Cysteine-Modified Variants of an Amino-Terminal Fragment of Bactericidal/Permeability-Increasing Protein by Horwitz, Arnold H., Leigh, Scott D., Abrahamson, Susan, Gazzano-Santoro, Hélène, Liu, Pei-Syan, Williams, Robert E., Carroll, Stephen F., Theofan, Georgia

“…rBPI23is a biologically active, recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI). While rBPI23is readily purified…”
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Inclusion of S-sepharose beads in the culture medium significantly improves recovery of secreted rBPI(21) from transfected CHO-K1 cells by Horwitz, A H, Carroll, S F, Williams, R E, Liu, P S

“…rBPI(23), a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), kills gram-negative bacteria and binds endotoxin…”
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Secretion of Functional Antibody and Fab Fragment from Yeast Cells by Horwitz, Arnold H., Chang, C. Paul, Better, Marc, Hellstrom, Karl Erik, Robinson, Randy R.

“…We have constructed yeast strains that secrete functional mouse--human chimeric antibody and its Fab fragment into the culture medium. For chimeric whole…”
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Human-engineered monoclonal antibodies retain full specific binding activity by preserving non-CDR complementarity-modulating residues by Studnicka, G M, Soares, S, Better, M, Williams, R E, Nadell, R, Horwitz, A H

“…Humanization of murine monoclonal antibodies for human therapy has commonly been achieved by complementarity-determining region (CDR) grafting, in which murine…”
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Human lipopolysaccharide-binding protein potentiates bactericidal activity of human bactericidal/permeability-increasing protein by HORWITZ, A. H, WILLIAMS, R. E, NOWAKOWSKI, G

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Potent Anti-CD5 Ricin A Chain Immunoconjugates from Bacterially Produced Fab' and F(ab') 2 by Better, Marc, Bernhard, Susan L., Lei, Shau-Ping, Fishwild, Dianne M., Lane, Julie A., Carroll, Stephen F., Howritz, Arnold H.

“…We have used genetic engineering to obtain secretion of anti-human CD5 antibody fragments from Escherichia coli for conjugation to the 30-kDa form of ricin A…”
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Chimeric immunoglobulin light chains are secreted at different levels: influence of framework-1 amino acids by Horwitz, A H, Nadell, R, Preugschat, F, Better, M

“…Immunoglobulin light chain proteins are generally thought to be readily secreted without their corresponding heavy chains; non-secreted light chains have been…”
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Competition between rBPI sub(23), a recombinant fragment of bactericidal/permeability-increasing protein, and lipopolysaccharide (LPS)-binding protein for binding to LPS and gram-negative bacteria by Gazzano-Santoro, H, Meszaros, K, Birr, C, Carroll, S F, Theofan, G, Horwitz, AH, Lim, E, Aberle, S, Kasler, H, Parent, J B

“…Lipopolysaccharide (LPS)-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are two structurally related lipid A-binding proteins…”
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Expression of engineered antibodies and antibody fragments in microorganisms by Better, M, Horwitz, A H

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Potent anti-CD5 ricin A chain immunoconjugates from bacterially produced Fab and F(ab') sub(2) by Better, M, Bernhard, S L, Lei, Shau-Ping, Fishwild, D M, Lane, JA, Carroll, S F, Horwitz, AH

“…We have used genetic engineering to obtain secretion of anti-human CD5 antibody fragments from Escherichia coli for conjugation to the 30-kDa form of ricin A…”
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Deoxyribonucleic acid sequence of araBAD promoter mutants of Escherichia coli by Horwitz, A H, Morandi, C, Wilcox, G

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DNA sequence of the araC regulatory gene from Escherichia coli B/r by Miyada, C.Garrett, Horwitz, Arnold H., Cass, Laura G., Timko, Josef, Wilcox, Gary

“…The DNA sequence of the araC regulatory gene from Escherichia coli B/r has been determined by the base-specific chemical cleavage reactions of Maxam and…”
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Characterization of a site-specific restriction endonuclease from Streptomyces aureofaciens by Timko, J, Horwitz, A H, Zelinka, J, Wilcox, G

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DNA sequence of the araBAD-araC controlling region in Salmonella typhimurium LT2 by Horwitz, A H, Heffernan, L, Morandi, C, Lee, J H, Timko, J, Wilcox, G

“…The araB and araC genes of Salmonella typhimurium have been cloned onto the plasmid pBR322. Restriction analysis and subcloning of restriction fragments…”
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The araIc mutation in Escherichia coli B/r by Cass, L G, Horwitz, A H, Wilcox, G

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