Search Results - "Horvath, Kent"

Telomere Length and the Cancer-Atherosclerosis Trade-Off by Stone, Rivka C, Horvath, Kent, Kark, Jeremy D, Susser, Ezra, Tishkoff, Sarah A, Aviv, Abraham

“…Modern humans, the longest-living terrestrial mammals, display short telomeres and repressed telomerase activity in somatic tissues compared with most…”
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Shorter telomere length in Europeans than in Africans due to polygenetic adaptation by Hansen, Matthew E B, Hunt, Steven C, Stone, Rivka C, Horvath, Kent, Herbig, Utz, Ranciaro, Alessia, Hirbo, Jibril, Beggs, William, Reiner, Alexander P, Wilson, James G, Kimura, Masayuki, De Vivo, Immaculata, Chen, Maxine M, Kark, Jeremy D, Levy, Daniel, Nyambo, Thomas, Tishkoff, Sarah A, Aviv, Abraham

“…Leukocyte telomere length (LTL), which reflects telomere length in other somatic tissues, is a complex genetic trait. Eleven SNPs have been shown in…”
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SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates by Sarkar, Jaya, Wan, Bingbing, Yin, Jinhu, Vallabhaneni, Haritha, Horvath, Kent, Kulikowicz, Tomasz, Bohr, Vilhelm A, Zhang, Yanbin, Lei, Ming, Liu, Yie

“…SLX4 assembles a toolkit of endonucleases SLX1, MUS81 and XPF, which is recruited to telomeres via direct interaction of SLX4 with TRF2. Telomeres present an…”
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SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres by Wan, Bingbing, Yin, Jinhu, Horvath, Kent, Sarkar, Jaya, Chen, Yong, Wu, Jian, Wan, Ke, Lu, Jian, Gu, Peili, Yu, Eun Young, Lue, Neal F, Chang, Sandy, Liu, Yie, Lei, Ming

“…SLX4 interacts with several endonucleases to resolve structural barriers in DNA metabolism. SLX4 also interacts with telomeric protein TRF2 in human cells. The…”
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Paternal age and telomere length in twins: the germ stem cell selection paradigm by Hjelmborg, Jacob B., Dalgård, Christine, Mangino, Massimo, Spector, Tim D., Halekoh, Ulrich, Möller, Sören, Kimura, Masayuki, Horvath, Kent, Kark, Jeremy D., Christensen, Kaare, Kyvik, Kirsten O., Aviv, Abraham

“…Summary Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres…”
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Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex by Yin, Jinhu, Wan, Bingbing, Sarkar, Jaya, Horvath, Kent, Wu, Jian, Chen, Yong, Cheng, Guangjuan, Wan, Ke, Chin, Peiju, Lei, Ming, Liu, Yie

“…The Fanconi anemia protein SLX4 assembles a genome and telomere maintenance toolkit, consisting of the nucleases SLX1, MUS81 and XPF. Although it is known that…”
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Human RECQL1 participates in telomere maintenance by Popuri, Venkateswarlu, Hsu, Joseph, Khadka, Prabhat, Horvath, Kent, Liu, Yie, Croteau, Deborah L., Bohr, Vilhelm A.

“…A variety of human tumors employ alternative and recombination-mediated lengthening for telomere maintenance (ALT). Human RecQ helicases, such as BLM and WRN,…”
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Sex difference in leukocyte telomere length is ablated in opposite-sex co-twins by BENETOS, Athanase, DALGARD, Christine, LABAT, Carlos, KARK, Jeremy D, VERHULST, Simon, CHRISTENSEN, Kaare, KIMURA, Masayuki, HORVATH, Kent, KYVIK, Kirsten Ohm, AVIV, Abraham

“…In eutherian mammals and in humans, the female fetus may be masculinized while sharing the intra-uterine environment with a male fetus. Telomere length (TL),…”
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DCAF4, a novel gene associated with leucocyte telomere length by Mangino, Massimo, Christiansen, Lene, Stone, Rivka, Hunt, Steven C, Horvath, Kent, Eisenberg, Dan T A, Kimura, Masayuki, Petersen, Inge, Kark, Jeremy D, Herbig, Utz, Reiner, Alex P, Benetos, Athanase, Codd, Veryan, Nyholt, Dale R, Sinnreich, Ronit, Christensen, Kaare, Nassar, Hisham, Hwang, Shih-Jen, Levy, Daniel, Bataille, Veronique, Fitzpatrick, Annette L, Chen, Wei, Berenson, Gerald S, Samani, Nilesh J, Martin, Nicholas G, Tishkoff, Sarah, Schork, Nicholas J, Kyvik, Kirsten Ohm, Dalgård, Christine, Spector, Timothy D, Aviv, Abraham

“…Leucocyte telomere length (LTL), which is fashioned by multiple genes, has been linked to a host of human diseases, including sporadic melanoma. A number of…”
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Human RECQL1 participates in telomere maintenance by Popuri, Venkateswarlu, Hsu, Joseph, Khadka, Prabhat, Horvath, Kent, Liu, Yie, Croteau, Deborah L, Bohr, Vilhelm A

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