Search Results - "Horvath, Anelia"

Dysregulated metabolic pathways in age-related macular degeneration by Zhang, Meng, Jiang, Nisi, Chu, Yi, Postnikova, Olga, Varghese, Rency, Horvath, Anelia, Cheema, Amrita K., Golestaneh, Nady

“…Age-related macular degeneration is a major cause of vision impairment in the Western world among people of 55 years and older. Recently we have shown that…”
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Clinical and Molecular Genetics of the Phosphodiesterases (PDEs) by Azevedo, Monalisa F, Faucz, Fabio R, Bimpaki, Eirini, Horvath, Anelia, Levy, Isaac, de Alexandre, Rodrigo B, Ahmad, Faiyaz, Manganiello, Vincent, Stratakis, Constantine A

“…Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of terminating cyclic nucleotide signaling by catalyzing the hydrolysis…”
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Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells by Mukhamedova, Nigora, Hoang, Anh, Dragoljevic, Dragana, Dubrovsky, Larisa, Pushkarsky, Tatiana, Low, Hann, Ditiatkovski, Michael, Fu, Ying, Ohkawa, Ryunosuke, Meikle, Peter J, Horvath, Anelia, Brichacek, Beda, Miller, Yury I, Murphy, Andrew, Bukrinsky, Michael, Sviridov, Dmitri

“…HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and…”
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Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation by Trivellin, Giampaolo, Daly, Adrian F, Faucz, Fabio R, Yuan, Bo, Rostomyan, Liliya, Larco, Darwin O, Schernthaner-Reiter, Marie Helene, Szarek, Eva, Leal, Letícia F, Caberg, Jean-Hubert, Castermans, Emilie, Villa, Chiara, Dimopoulos, Aggeliki, Chittiboina, Prashant, Xekouki, Paraskevi, Shah, Nalini, Metzger, Daniel, Lysy, Philippe A, Ferrante, Emanuele, Strebkova, Natalia, Mazerkina, Nadia, Zatelli, Maria Chiara, Lodish, Maya, Horvath, Anelia, de Alexandre, Rodrigo Bertollo, Manning, Allison D, Levy, Isaac, Keil, Margaret F, Sierra, Maria de la Luz, Palmeira, Leonor, Coppieters, Wouter, Georges, Michel, Naves, Luciana A, Jamar, Mauricette, Bours, Vincent, Wu, T. John, Choong, Catherine S, Bertherat, Jerome, Chanson, Philippe, Kamenický, Peter, Farrell, William E, Barlier, Anne, Quezado, Martha, Bjelobaba, Ivana, Stojilkovic, Stanko S, Wess, Jurgen, Costanzi, Stefano, Liu, Pengfei, Lupski, James R, Beckers, Albert, Stratakis, Constantine A

“…A duplicated segment of the X chromosome causes pediatric gigantism through increased levels of growth hormone. A gene in the duplicated region that encodes a…”
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SCReadCounts: estimation of cell-level SNVs expression from scRNA-seq data by Prashant, N M, Alomran, Nawaf, Chen, Yu, Liu, Hongyu, Bousounis, Pavlos, Movassagh, Mercedeh, Edwards, Nathan, Horvath, Anelia

“…Recent studies have demonstrated the utility of scRNA-seq SNVs to distinguish tumor from normal cells, characterize intra-tumoral heterogeneity, and define…”
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Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer by Wang, Bi-Dar, Ceniccola, Kristin, Hwang, SuJin, Andrawis, Ramez, Horvath, Anelia, Freedman, Jennifer A., Olender, Jacqueline, Knapp, Stefan, Ching, Travers, Garmire, Lana, Patel, Vyomesh, Garcia-Blanco, Mariano A., Patierno, Steven R., Lee, Norman H.

“…Clinical challenges exist in reducing prostate cancer (PCa) disparities. The RNA splicing landscape of PCa across racial populations has not been fully…”
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Embryonic stem cell factor FOXD3 (Genesis) defects in gastrointestinal stromal tumors by Faucz, Fabio R, Horvath, Anelia D, Assié, Guillaume, Almeida, Madson Q, Szarek, Eva, Boikos, Sosipatros, Angelousi, Anna, Levy, Isaac, Maria, Andrea G, Chitnis, Ajay, Antonescu, Cristina R, Claus, Rainer, Bertherat, Jérôme, Plass, Christoph, Eng, Charis, Stratakis, Constantine A

“…Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms, believed to originate from the interstitial cells of Cajal (ICC), often caused by…”
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Sex-dependent transcription of cardiac electrophysiology and links to acetylation modifiers based on the GTEx database by Pressler, Michael P., Horvath, Anelia, Entcheva, Emilia

“…Development of safer drugs based on epigenetic modifiers, e.g., histone deacetylase inhibitors (HDACi), requires better understanding of their effects on…”
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scReQTL: an approach to correlate SNVs to gene expression from individual scRNA-seq datasets by Liu, Hongyu, Prashant, N M, Spurr, Liam F, Bousounis, Pavlos, Alomran, Nawaf, Ibeawuchi, Helen, Sein, Justin, Słowiński, Piotr, Tsaneva-Atanasova, Krasimira, Horvath, Anelia

“…Recently, pioneering expression quantitative trait loci (eQTL) studies on single cell RNA sequencing (scRNA-seq) data have revealed new and cell-specific…”
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Prostate cancer cell-platelet bidirectional signaling promotes calcium mobilization, invasion and apoptotic resistance via distinct receptor-ligand pairs by Garofano, Kaitlin, Rashid, Kameron, Smith, Michael, Brantner, Christine, Suwunnakorn, Sumanun, Diemert, David, Gordon, Olivia, Horvath, Anelia, Khan, Sikandar, Popratiloff, Anastas, Rhim, Johng, Sidahmed, Alfateh, Maggirwar, Sanjay B., O’Brien, Travis J., Perera, Minoli A., Lee, Norman H.

“…Platelets play a crucial role in cancer and thrombosis. However, the receptor-ligand repertoire mediating prostate cancer (PCa) cell-platelet interactions and…”
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Cell therapy using ex vivo reprogrammed macrophages enhances antitumor immune responses in melanoma by Noonepalle, Satish Kumar Reddy, Gracia-Hernandez, Maria, Aghdam, Nima, Berrigan, Michael, Coulibaly, Hawa, Li, Xintang, Zevallos-Delgado, Christian, Pletcher, Andrew, Weselman, Bryan, Palmer, Erica, Knox, Tessa, Sotomayor, Eduardo, Chiappinelli, Katherine B, Wardrop, Duncan, Horvath, Anelia, Shook, Brett A, Lee, Norman, Dritschilo, Anatoly, Fernandes, Rohan, Musunuri, Karthik, Shibata, Maho, Villagra, Alejandro

“…Macrophage-based cell therapies have shown modest success in clinical trials, which can be attributed to their phenotypic plasticity, where transplanted…”
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Systematic pan-cancer analysis of somatic allele frequency by Spurr, Liam, Li, Muzi, Alomran, Nawaf, Zhang, Qianqian, Restrepo, Paula, Movassagh, Mercedeh, Trenkov, Chris, Tunnessen, Nerissa, Apanasovich, Tatiyana, Crandall, Keith A., Edwards, Nathan, Horvath, Anelia

“…Imbalanced expression of somatic alleles in cancer can suggest functional and selective features, and can therefore indicate possible driving potential of the…”
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Evaluation of an angiotensin Type 1 receptor blocker on the reconsolidation of fear memory by Swiercz, Adam P., Iyer, Laxmi, Yu, Zhe, Edwards, Allison, Prashant, N. M., Nguyen, Bryan N., Horvath, Anelia, Marvar, Paul J.

“…Inhibition of the angiotensin type 1 receptor (AT 1 R) has been shown to decrease fear responses in both humans and rodents. These effects are attributed to…”
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Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome by Karpinski, Beverly A, Maynard, Thomas M, Bryan, Corey A, Yitsege, Gelila, Horvath, Anelia, Lee, Norman H, Moody, Sally A, LaMantia, Anthony-Samuel

“…22q11.2 Deletion Syndrome (22q11DS) is a neurodevelopmental disorder associated with cranial nerve anomalies and disordered oropharyngeal function, including…”
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Identification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profiling by Motwani, Mona, Li, Da-Qiang, Horvath, Anelia, Kumar, Rakesh

“…P21-activated kinase 1 (PAK1), a serine/threonine protein kinase, modulates many cellular processes by phosphorylating its downstream substrates. In addition…”
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Carney complex and lentiginosis by Horvath, Anelia, Stratakis, Constantine A.

“…Summary Initially described as the ‘complex of myxomas, spotty skin pigmentation and endocrine overactivity,’ Carney complex (CNC) is known as an autosomal…”
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Genomic insights into triple-negative and HER2-positive breast cancers using isogenic model systems by Mudvari, Prakriti, Ohshiro, Kazufumi, Nair, Vasudha, Horvath, Anelia, Kumar, Rakesh

“…In general, genomic signatures of breast cancer subtypes have little or no overlap owing to the heterogeneous genetic backgrounds of study samples. Thus,…”
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Phosphodiesterase sequence variants may predispose to prostate cancer by de Alexandre, Rodrigo B, Horvath, Anelia D, Szarek, Eva, Manning, Allison D, Leal, Leticia F, Kardauke, Fabio, Epstein, Jonathan A, Carraro, Dirce M, Soares, Fernando A, Apanasovich, Tatiyana V, Stratakis, Constantine A, Faucz, Fabio R

“…We hypothesized that mutations that inactivate phosphodiesterase (PDE) activity and lead to increased cAMP and cyclic guanosine monophosphate levels may be…”
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BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity by Wu, Bogang, Qi, Leilei, Chiang, Huai-Chin, Pan, Haihui, Zhang, Xiaowen, Greenbaum, Alexandra, Stark, Elizabeth, Wang, Li-Ju, Chen, Yidong, Haddad, Bassem R., Clagett, Dionyssia, Isaacs, Claudine, Elledge, Richard, Horvath, Anelia, Hu, Yanfen, Li, Rong

“…Women with BRCA1 germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in…”
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Clinical and molecular genetics of acromegaly: MEN1, Carney complex, McCune–Albright syndrome, familial acromegaly and genetic defects in sporadic tumors by Horvath, Anelia, Stratakis, Constantine A.

“…Pituitary tumors are among the most common neoplasms in man; they account for approximately 15% of all primary intracranial lesions (Jagannathan et al.,…”
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