Search Results - "Horvatek, Petra"
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Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ
Published in Scientific reports (01-02-2018)“…The nutritional alarmones ppGpp and pppGpp (collectively: (p)ppGpp) are nucleotide-based second messengers enabling bacteria to respond to environmental and…”
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Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus
Published in PLoS genetics (01-07-2018)“…The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus…”
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Inducible expression of (pp)pGpp synthetases in Staphylococcus aureus is associated with activation of stress response genes
Published in PLoS genetics (01-12-2020)“…The stringent response is characterized by the synthesis of the messenger molecules pppGpp, ppGpp or pGpp (here collectively designated (pp)pGpp). The…”
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Next Generation Sequencing of Free Microbial DNA for Rapid Identification of Pathogens in Critically Ill Children with Systemic Inflammatory Response Syndrome (SIRS)
Published in Frontiers in bioscience (Landmark. Print) (08-11-2022)“…Infections, major surgeries, and hyperinflammatory syndromes are known to trigger Systemic Inflammatory Response Syndrome (SIRS). Discrimination between…”
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The alarmone (p)ppGpp confers tolerance to oxidative stress during the stationary phase by maintenance of redox and iron homeostasis in Staphylococcus aureus
Published in Free radical biology & medicine (01-12-2020)“…Slow growing stationary phase bacteria are often tolerant to multiple stressors and antimicrobials. Here, we show that the pathogen Staphylococcus aureus…”
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Inducible expression of
Published in PLoS genetics (30-12-2020)“…The stringent response is characterized by the synthesis of the messenger molecules pppGpp, ppGpp or pGpp (here collectively designated (pp)pGpp). The…”
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Regulation of the opposing
Published in PLoS genetics (09-07-2018)“…The stringent response is characterized by (p)ppGpp synthesis resulting in repression of translation and reprogramming of the transcriptome. In Staphylococcus…”
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