National Guidelines for the Performance of the Sweat Test in Diagnosis of Cystic Fibrosis on behalf of the Croatian Society of Medical Biochemistry and Laboratory Medicine and the Cystic Fibrosis Centre - Paediatrics and adults, University Hospital Centre Zagreb

The sweat test (ST) is a cornerstone in the diagnosis of cystic fibrosis (CF), together with newborn screening and genetic testing. However, the performance of the ST can depend on the operator's skill, so several international guidelines have been published to standardise the ST, but inconsist...

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Bibliographic Details
Published in:	Biochemia medica Vol. 32; no. 1; pp. 010501 - 23
Main Authors:	Leniček Krleža, Jasna, Aralica, Merica, Tješić-Drinković, Duška, Crneković, Karolina, Culej, Jelena, Fressl Juroš, Gordana, Horvat, Verica, Metzner, Dara, Pamuković Jaram, Dijana, Pipić Kitter, Alma, Smaić, Fran, Šimić Vojak, Sanela, Šimičević, Livija, Verić, Valentina
Format:	Journal Article
Language:	English
Published:	Croatia Medicinska naklada 15-02-2022 Croatian Society of Medical Biochemistry and Laboratory Medicine
Subjects:	Child Cystic Fibrosis - diagnosis Hospitals, University Humans Infant, Newborn Laboratories Pediatrics Reviews Sweat
Online Access:	Get full text
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Summary:	The sweat test (ST) is a cornerstone in the diagnosis of cystic fibrosis (CF), together with newborn screening and genetic testing. However, the performance of the ST can depend on the operator's skill, so several international guidelines have been published to standardise the ST, but inconsistencies remain. The joint Working Group for ST Standardisation (WG STS) of the Croatian Society of Medical Biochemistry and Laboratory Medicine, in association with cistic fybrosis health professional and the Cistic Fibrosis Centre for Paediatrics and Adults, have issued National Guidelines for the Performance of the Sweat Test in order to ensure consistency in ST performance and accuracy of reported results. Many of the standards were taken from the 2nd Edition of the UK Guidelines for Performance of the ST for the Diagnosis of CF, while others were taken from independent consensus statements from the WG STS based on local ST equipment and practices. The standards cover every step of the ST, from the indications for testing to reporting of results and their interpretation, including the analytical phase and quality control. In addition, National Guidelines include appendices with practical examples in order to aid implementation of the recommendations in routine practice.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 272428 The first two authors contributed equally to this work.
ISSN:	1330-0962 1846-7482
DOI:	10.11613/BM.2022.010501