Occupational Chlorophenol Exposure and Soft Tissue Sarcoma Risk among Men Aged 30-60 Years

Occupational Chlorophenol Exposure and Soft Tissue Sarcoma Risk among Men Aged 30-60 Years

To evaluate the association of chlorophenol exposure with soft tissue sarcoma risk Independent of phenoxyherbicide exposure, the authors analyzed data from the Selected Cancers Study, a population-based case-control study that included 295 male soft tissue sarcoma cases, aged 32–60 years, from eight...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology Vol. 148; no. 7; pp. 693 - 703
Main Authors: Hoppin, Jane A., Tolbert, Paige E., Herrick, Robert F., Freedman, David S., Ragsdale, Bruce D., Horvat, Karen R., Brann, Edward A.
Format: Journal Article
Language:English
Published: Cary, NC Oxford University Press 01-10-1998
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
Chemical and industrial products toxicology. Toxic occupational diseases
chlorophenols
Chlorophenols - adverse effects
Herbicides - adverse effects
Humans
Male
Medical sciences
Middle Aged
Occupational Exposure
oils
Prevalence
Risk Factors
sarcoma
Sarcoma - epidemiology
Sarcoma - etiology
soft tissue
Soft Tissue Neoplasms - epidemiology
Soft Tissue Neoplasms - etiology
Toxicology
Various organic compounds
United States
North America
America
Human
Chlorophenol
Sarcoma
Toxicity
Risk factor
Male
Soft tissue
Malignant tumor
Occupational exposure
Epidemiology
Occupational medicine
Public health
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the association of chlorophenol exposure with soft tissue sarcoma risk Independent of phenoxyherbicide exposure, the authors analyzed data from the Selected Cancers Study, a population-based case-control study that included 295 male soft tissue sarcoma cases, aged 32–60 years, from eight population-based cancer registries and 1, 908 male controls. Chlorophenol exposure was assigned using both an intensity and a confidence estimate by an industrial hygienist based on verbatim Job descriptions. Seventeen percent of the jobs rated as high intensity involved wood preservation, while 82% involved cutting oils. Soft tissue sarcoma risk, modeled using conditional logistic regression, was significantly associated with ever having high-intensity chlorophenol exposure (odds ratio = 1. 79, 95% confidence interval 1. 10–2.88). A duration response trend was evident among more highly exposed subjects (p for trend < 0. 0001). For subjects with 10 or more years of substantial exposure, the odds ratio was 7. 78 (95% confidence interval 2. 46–24.65). These results suggest that chlorophenol exposure independent of phenoxyherbicides may increase the risk of soft tissue sarcoma. Because of the large number of machinists in the exposed group and the complex composition of cutting fluids, it is possible that another exposure involved in machining is responsible for the observed excess risk. Am J Epidemiol 1998; 148: 693–703.
Bibliography:ark:/67375/HXZ-NLR1HHFX-R
istex:6A7EB25A3AC89CC5C96E26E63209643E10E855AF
ArticleID:148.7.693
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/148.7.693