Search Results - "Horton, Walter E"

Advanced Osteoarthritis in Humans Is Associated With Altered Collagen VI Expression and Upregulation of ER-stress Markers Grp78 and Bag-1 by Nugent, Ashleigh E, Speicher, Danielle M, Gradisar, Ian, McBurney, Denise L, Baraga, Anthony, Doane, Kathleen J, Horton, Walter E., Jr

“…To test the hypothesis that a perturbation of endoplasmic reticulum (ER) function is involved in the pathogenesis of osteoarthritis (OA), articular cartilage…”
Get full text

Multiple Signals Induce Endoplasmic Reticulum Stress in Both Primary and Immortalized Chondrocytes Resulting in Loss of Differentiation, Impaired Cell Growth, and Apoptosis by Yang, Ling, Carlson, Sara G., McBurney, Denise, Horton, Walter E.

“…The endoplasmic reticulum is the site of synthesis and folding of secretory proteins and is sensitive to changes in the internal and external environment of…”
Get full text

Highly Hydrophobic Electrospun Fiber Mats from Polyisobutylene-Based Thermoplastic Elastomers by Lim, Goy Teck, Puskas, Judit E, Reneker, Darrell H, Jákli, Antal, Horton, Walter E

“…This paper is the first report of electrospinning neat polyisobutylene-based thermoplastic elastomers. Two generations of these materials are investigated: a…”
Get full text

The presence of extracellular matrix alters the chondrocyte response to endoplasmic reticulum stress by Nugent, Ashleigh E., McBurney, Denise L., Horton Jr, Walter E.

“…The objective of this study was to test the hypothesis that extracellular matrix (ECM) would alter the endoplasmic reticulum (ER) stress response of…”
Get full text

Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype by Yagi, Rieko, McBurney, Denise, Laverty, David, Weiner, Scott, Horton, Walter E.

“…Osteoarthritis (OA) is a degenerative cartilage disease with varying degrees of severity within a given joint. The purpose of this study was to define a…”
Get full text

Metapodial or Phalanx? An Evolutionary and Developmental Perspective on the Homology of the First Ray's Proximal Segment by RENO, PHILIP L., HORTON Jr, WALTER E., LOVEJOY, C. Owen

“…The first mammalian metapodial (MP1) has periodically been argued to actually be a phalanx, because the first ray has one less element than the four posterior…”
Get full text

ECM Production of Primary Human and Bovine Chondrocytes in Hybrid PEG Hydrogels Containing Type I Collagen and Hyaluronic Acid by Callahan, Laura A. Smith, Ganios, Anna M., McBurney, Denise L., Dilisio, Matthew F., Weiner, Scott D., Horton, Walter E., Becker, Matthew L.

“…The development of advanced materials that facilitate hyaline cartilage formation and regeneration in aging populations is imperative. Critical to the success…”
Get full text

A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes by Yang, Ling, McBurney, Denise, Tang, Shou-Ching, Carlson, Sara G., Horton Jr, Walter E.

“…BAG‐1 (Bcl‐2 associated athanogene‐1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. In vivo, BAG‐1 is…”
Get full text

Characterization of ex vivo-generated bovine and human cartilage by immunohistochemical, biochemical, and magnetic resonance imaging analyses by Nugent, Ashleigh E, Reiter, David A, Fishbein, Kenneth W, McBurney, Denise L, Murray, Travis, Bartusik, Dorota, Ramaswamy, Sharan, Spencer, Richard G, Horton, Jr, Walter E

“…Osteoarthritis (OA) is a prevalent age-associated disease involving altered chondrocyte homeostasis and cartilage degeneration. The avascular nature of…”
Get more information

Bcl-2 Positively Regulates Sox9-dependent Chondrocyte Gene Expression by Suppressing the MEK-ERK1/2 Signaling Pathway by Yagi, Rieko, McBurney, Denise, Horton, Walter E.

“…Bcl-2 is an anti-apoptotic protein that has recently been shown to regulate other cellular functions. We previously reported that Bcl-2 regulates chondrocyte…”
Get full text

Growth plate formation and development in alligator and mouse metapodials: evolutionary and functional implications by Reno, Philip L., Horton Jr, Walter E., Elsey, Ruth M., Lovejoy, C. Owen

“…Mammalian metapodials (metacarpals and metatarsals), unlike most long bones, form a single growth plate, and undergo longitudinal growth at only one end. The…”
Get full text

Fourier transform infrared imaging spectroscopic analysis of tissue engineered cartilage: histologic and biochemical correlations by Kim, Minwook, Bi, Xiaohong, Horton, Walter E, Spencer, Richard G, Camacho, Nancy P

“…The composition of cartilage is predictive of its in vivo performance. Therefore, the ability to assess its primary macromolecular components, proteoglycan…”
Get more information

Cryopreservation of porcine articular cartilage: MRI and biochemical results after different freezing protocols by Laouar, Leila, Fishbein, Ken, McGann, Locksley E., Horton, Walter E., Spencer, Richard G., Jomha, Nadr M.

“…The objective of this study was to investigate the effects of cryopreservation on the components of articular cartilage (AC) matrix by utilizing magnetic…”
Get full text

Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability by Kinkel, Mary D., Horton Jr, Walter E.

“…The anti‐apoptotic protein Bcl‐2 has been shown to function in roles unrelated to apoptosis in a variety of cell types. We have previously reported that loss…”
Get full text

Increased Chondrocyte Apoptosis in Growth Plates From Children With Slipped Capital Femoral Epiphysis by Adamczyk, Mark J, Weiner, Dennis S, Nugent, Ashleigh, McBurney, Denise, Horton, Walter E

“…Ultrastructural studies of slipped capital femoral epiphysis (SCFE) growth plates have shown diminished cellularity and marked distortion of the architecture…”
Get full text

An association between an aggrecan polymorphic allele and bilateral hand osteoarthritis in elderly white men: data from the Baltimore Longitudinal Study of Aging (BLSA) by Horton Jr, Walter E., Lethbridge-Çejku, M., Hochberg, Marc C., Balakir, Richard, Precht, Patricia, Plato, Chris C., Tobin, Jordan D., Meek, L., Doege, Kurt

“…Objective: The aggrecan proteoglycan is a major component of articular cartilage and supports the biomechanical function of this tissue. A variable number…”
Get full text

Cytokine Inducible Matrix Metalloproteinase Expression in Immortalized Rat Chondrocytes Is Independent of Nitric Oxide Stimulation by Walter E. Horton, Jr, Imelda Udo, Patricia Precht, Balakir, Richard, Karen Hasty

“…The objective of this study was to determine if an immortalized mammalian chondrocyte cell line had a profile of matrix metalloproteinase (MMP) expression that…”
Get full text

Age‐related expression patterns of Bag‐1 and Bcl‐2 in growth plate and articular chondrocytes by Kinkel, Mary D., Yagi, Rieko, McBurney, Denise, Nugent, Ashleigh, Horton, Walter E.

“…Aging cartilage displays increased chondrocyte apoptosis and decreased responsiveness of chondrocytes to growth factors. The molecular mechanisms responsible…”
Get full text

Ossification of the mouse metatarsal: Differentiation and proliferation in the presence/absence of a defined growth plate by Reno, Philip L., Mcburney, Denise L., Lovejoy, C. Owen, Horton, Walter E.

“…There is significant diversity in growth plate behavior among sites within an individual skeleton and between skeletons of different species. This variation…”
Get full text

Bcl-2 regulates chondrocyte morphology and aggrecan gene expression independent of caspase activation and full apoptosis by Feng, Lixin, Balakir, Richard, Precht, Patricia, Horton Jr, Walter E.

“…Bcl‐2 is widely expressed in a variety of cell types and is known to block apoptosis through a conserved pathway. However, recent reports have demonstrated…”
Get full text