Search Results - "Horton, Jason"

Variable osteogenic performance of MC3T3-E1 subclones impacts their utility as models of osteoblast biology by Hwang, Phillip W., Horton, Jason A.

“…The spontaneously immortalized murine calvarial cell line MC3T3-E1 and its derivative subclones are widely used models of osteoblast biology. Many…”
Get full text

Cell cycle arrest and apoptosis are early events in radiosensitization of EWS::FLI1+ Ewing sarcoma cells by Mithramycin A by Lin, Mei Yun, Damron, Timothy A., Horton, Jason A.

“…The oncogenic fusion protein EWS::FLI1 is an attractive therapeutic target in Ewing sarcoma (ES). Mithramycin A (MithA) is a potent and specific inhibitor of…”
Get full text

Role of Type II Pneumocyte Senescence in Radiation-Induced Lung Fibrosis by CITRIN, Deborah E, SHANKAVARAM, Uma, HORTON, Jason A, SHIELD, William, SHUPING ZHAO, ASANO, Hiroaki, WHITE, Ayla, SOWERS, Anastasia, THETFORD, Angela, EUN JOO CHUNG

“…Radiation is a commonly delivered therapeutic modality for cancer. The causes underlying the chronic, progressive nature of radiation injury in the lung are…”
Get full text

Mesenchymal stem cells inhibit cutaneous radiation‐induced fibrosis by suppressing chronic inflammation by Horton, Jason A., Hudak, Kathryn E., Chung, Eun Joo, White, Ayla O., Scroggins, Bradley T., Burkeen, Jeffrey F., Citrin, Deborah E.

“…Exposure to ionizing radiation (IR) can result in the development of cutaneous fibrosis, for which few therapeutic options exist. We tested the hypothesis that…”
Get full text

In vitro model to study confined osteocyte networks exposed to flow-induced mechanical stimuli by Zhang, Kairui, Ogando, Courtney, Filip, Alex, Zhang, Teng, Horton, Jason A, Soman, Pranav

“…Osteocytes are considered the primary mechanical sensor in bone tissue and orchestrate the coupled bone remodeling activity of adjacent osteoblast and…”
Get more information

Editorial: Bone marrow adiposity - contributions to bone, aging and beyond by Horton, Jason A, Beck-Cormier, Sarah, van Wijnen, Andre J

“…Realizing the vision of the International Bone Marrow Adiposity Society The International Bone Marrow Adiposity Society (BMAS) has held 7 annual meetings since…”
Get full text

IL-13 is a therapeutic target in radiation lung injury by Chung, Su I., Horton, Jason A., Ramalingam, Thirumalai R., White, Ayla O., Chung, Eun Joo, Hudak, Kathryn E., Scroggins, Bradley T., Arron, Joseph R., Wynn, Thomas A., Citrin, Deborah E.

“…Pulmonary fibrosis is a potentially lethal late adverse event of thoracic irradiation. Prior research indicates that unrestrained TGF-β1 and/or type 2…”
Get full text

The vascular origins of antero‐medial tibial bowing in congenital fibular deficiency by Horton, Jason A., Hootnick, David R.

“…Anteromedial bowing and shortening of the tibia are intrinsic features of limbs with congenital fibular deficiency (CFD). Tibial bowing occurs more frequently…”
Get full text

Quercetin Inhibits Radiation-Induced Skin Fibrosis by Horton, Jason A., Li, Fei, Chung, Eun Joo, Hudak, Kathryn, White, Ayla, Krausz, Kristopher, Gonzalez, Frank, Citrin, Deborah

“…Radiation induced fibrosis of the skin is a late toxicity that may result in loss of function due to reduced range of motion and pain. The current study sought…”
Get full text

Mithramycin A Radiosensitizes EWS:Fli1+ Ewing Sarcoma Cells by Inhibiting Double Strand Break Repair by Lin, Mei Yun, Damron, Timothy A., Oest, Megan E., Horton, Jason A.

“…The oncogenic EWS:Fli1 fusion protein is a key transcriptional mediator of Ewing sarcoma initiation, progression, and therapeutic resistance. Mithramycin A…”
Get full text

Progressive loss of implant fixation in a preclinical rat model of cemented knee arthroplasty by Mann, Kenneth A., Miller, Mark A., Rossow, Jeffrey K., Tatusko, Megan E., Horton, Jason A., Damron, Timothy A., Oest, Megan E.

“…Aseptic loosening of total knee arthroplasty continues to be a challenging clinical problem. The progression of the loosening process, from the initial…”
Get full text

Early Changes in Cement–Bone Fixation Using a Novel Rat Knee Replacement Model by Mann, Kenneth A., Miller, Mark A., Amendola, Richard L., Cyndari, Karen I., Horton, Jason A., Damron, Timothy A., Oest, Megan E.

“…ABSTRACT Trabecular resorption from interdigitated regions between cement and bone has been found in postmortem‐retrieved knee replacements, but the viability…”
Get full text

Perfusion-based co-culture model system for bone tissue engineering by W. Sawyer, Stephen, Zhang, Kairui, A. Horton, Jason, Soman, Pranav

“…In this work, we report on a perfusion-based co-culture system that could be used for bone tissue engineering applications. The model system is created using a…”
Get full text

Transforming Growth Factor Alpha is a Critical Mediator of Radiation Lung Injury by Chung, Eun Joo, Hudak, Kathryn, Horton, Jason A., White, Ayla, Scroggins, Bradley T., Vaswani, Shiva, Citrin, Deborah

“…Radiation fibrosis of the lung is a late toxicity of thoracic irradiation. Epidermal growth factor (EGF) signaling has previously been implicated in radiation…”
Get full text

Perfusion directed 3D mineral formation within cell-laden hydrogels by Sawyer, Stephen W, Shridhar, Shivkumar Vishnempet, Zhang, Kairui, Albrecht, Lucas D, Filip, Alex B, Horton, Jason A, Soman, Pranav

“…Despite the promise of stem cell engineering and the new advances in bioprinting technologies, one of the major challenges in the manufacturing of large scale…”
Get more information

Inhibition of radiation-induced skin fibrosis with imatinib by Horton, Jason A., Chung, Eun Joo, Hudak, Kathryn E., Sowers, Anastasia, Thetford, Angela, White, Ayla O., Mitchell, James B., Citrin, Deborah E.

“…Abstract Purpose: Dermal fibrosis is a disabling late toxicity of radiotherapy. Several lines of evidence suggest that overactive signaling via the…”
Get full text

Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways by Wang, Yan, Middleton, Frank, Horton, Jason A., Reichel, Lee, Farnum, Cornelia E., Damron, Timothy A.

“…Longitudinal bone growth results from coordination of proliferation and hypertrophy of chondrocytes, calcification of the matrix, vascular invasion, and…”
Get full text

Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways by Zhang, Mingliang, Pritchard, Meredith R, Middleton, Frank A, Horton, Jason A, Damron, Timothy A

“…Abstract In the growth plate, the reserve and perichondral zones have been hypothesized to have similar functions, but their exact functions are poorly…”
Get full text

In Vivo Assessment of HER2 Receptor Density in HER2-Positive Tumors by Near-Infrared Imaging, Using Repeated Injections of the Fluorescent Probe by Ardeshirpour, Yasaman, Hassan, Moinuddin, Zielinski, Rafal, Horton, Jason A., Capala, Jacek, Gandjbakhche, Amir H., Chernomordik, Victor

“…HER2 overexpression and amplification of the HER2/neu gene have been found in approximately 25% of invasive breast carcinomas. They are associated with a poor…”
Get full text

Microarray Cluster Analysis of Irradiated Growth Plate Zones Following Laser Microdissection by Damron, Timothy A., M.D, Zhang, Mingliang, Ph.D, Pritchard, Meredith R., B.S, Middleton, Frank A., Ph.D, Horton, Jason A., M.S, Margulies, Bryan M., Ph.D, Strauss, Judith A., B.S, Farnum, Cornelia E., Ph.D, Spadaro, Joseph A., Ph.D

“…Purpose Genes and pathways involved in early growth plate chondrocyte recovery after fractionated irradiation were sought as potential targets for selective…”
Get full text