Search Results - "Horst, Reto"

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor by Eddy, Matthew T., Lee, Ming-Yue, Gao, Zhan-Guo, White, Kate L., Didenko, Tatiana, Horst, Reto, Audet, Martin, Stanczak, Pawel, McClary, Kyle M., Han, Gye Won, Jacobson, Kenneth A., Stevens, Raymond C., Wüthrich, Kurt

“…Signaling across cellular membranes, the 826 human G protein-coupled receptors (GPCRs) govern a wide range of vital physiological processes, making GPCRs…”
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes by Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

“…Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein…”
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NMR spectroscopy: the swiss army knife of drug discovery by Horst, Reto, Farley, Kathleen A., Kormos, Bethany L., Withka, Jane M.

“…Nuclear magnetic resonance (NMR) spectroscopy has evolved into a powerful tool within drug discovery over the last two decades. While traditionally being used…”
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A covalent BTK ternary complex compatible with targeted protein degradation by Schiemer, James, Maxwell, Andrew, Horst, Reto, Liu, Shenping, Uccello, Daniel P., Borzilleri, Kris, Rajamohan, Nisha, Brown, Matthew F., Calabrese, Matthew F.

“…Targeted protein degradation using heterobifunctional chimeras holds the potential to expand target space and grow the druggable proteome. Most acutely, this…”
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Solution-NMR Characterization of Outer-Membrane Protein A from E. coli in Lipid Bilayer Nanodiscs and Detergent Micelles by Sušac, Lukas, Horst, Reto, Wüthrich, Kurt

“…X‐ray crystallography and solution NMR of detergent‐reconstituted OmpA (outer membrane protein A from E. coli) had shown that this protein forms an…”
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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes by Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.

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Translational Diffusion of Macromolecular Assemblies Measured Using Transverse-Relaxation-Optimized Pulsed Field Gradient NMR by Horst, Reto, Horwich, Arthur L, Wüthrich, Kurt

“…In structural biology, pulsed field gradient (PFG) NMR spectroscopy for the characterization of size and hydrodynamic parameters of macromolecular solutes has…”
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Direct NMR Observation of a Substrate Protein Bound to the Chaperonin GroEL by Horst, Reto, Bertelsen, Eric B., Fiaux, Jocelyne, Wider, Gerhard, Horwich, Arthur L., Wüthrich, Kurt

“…The reaction cycle and the major structural states of the molecular chaperone GroEL and its cochaperone, GroES, are well characterized. In contrast, very…”
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NMR Structure Reveals Intramolecular Regulation Mechanism for Pheromone Binding and Release by Horst, Reto, Damberger, Fred, Luginbühl, Peter, Güntert, Peter, Peng, Guihong, Nikonova, Larisa, Leal, Walter S., Wüthrich, Kurt

“…Odorants are transmitted by small hydrophobic molecules that cross the aqueous sensillar lymph surrounding the dendrites of the olfactory neurons to stimulate…”
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Folding trajectories of human dihydrofolate reductase inside the GroEL-GroES chaperonin cavity and free in solution by Horst, Reto, Fenton, Wayne A, Englander, S. Walter, Wüthrich, Kurt, Horwich, Arthur L

“…The chaperonin GroEL binds non-native polypeptides in an open ring via hydrophobic contacts and then, after ATP and GroES binding to the same ring as…”
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Nuclear Magnetic Resonance Structure of the N-Terminal Domain of Nonstructural Protein 3 from the Severe Acute Respiratory Syndrome Coronavirus by SERRANO, Pedro, JOHNSON, Margaret A, STEVENS, Raymond C, KUHN, Peter, WÜTHRICH, Kurt, ALMEIDA, Marcius S, HORST, Reto, HERRMANN, Torsten, JOSEPH, Jeremiah S, NEUMAN, Benjamin W, SUBRAMANIAN, Vanitha, SAIKATENDU, Kumar S, BUCHMEIER, Michael J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Micro-scale NMR Experiments for Monitoring the Optimization of Membrane Protein Solutions for Structural Biology by Horst, Reto, Wüthrich, Kurt

“…Reconstitution of integral membrane proteins (IMP) in aqueous solutions of detergent micelles has been extensively used in structural biology, using either…”
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Proton-Proton Overhauser NMR Spectroscopy with Polypeptide Chains in Large Structures by Horst, Reto, Wider, Gerhard, Fiaux, Jocelyne, Bertelsen, Eric B., Horwich, Arthur L., Wüthrich, Kurt

“…The use of ¹H-¹H nuclear Overhauser effects (NOE) for structural studies of uniformly deuterated polypeptide chains in large structures is investigated by…”
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Managing the solvent water polarization to obtain improved NMR spectra of large molecular structures by Hiller, Sebastian, Wider, Gerhard, Etezady-Esfarjani, Touraj, Horst, Reto, Wüthrich, Kurt

“…In large molecular structures, the magnetization of all hydrogen atoms in the solute is strongly coupled to the water magnetization through chemical exchange…”
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Comparison of NMR and crystal structures highlights conformational isomerism in protein active sites by Serrano, Pedro, Pedrini, Bill, Geralt, Michael, Jaudzems, Kristaps, Mohanty, Biswaranjan, Horst, Reto, Herrmann, Torsten, Elsliger, Marc-André, Wilson, Ian A., Wüthrich, Kurt

“…The JCSG has recently developed a protocol for systematic comparisons of high‐quality crystal and NMR structures of proteins. In this paper, the extent to…”
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Comparison of NMR and crystal structures for the proteins TM1112 and TM1367 by Mohanty, Biswaranjan, Serrano, Pedro, Pedrini, Bill, Jaudzems, Kristaps, Geralt, Michael, Horst, Reto, Herrmann, Torsten, Elsliger, Marc-André, Wilson, Ian A., Wüthrich, Kurt

“…The NMR structures of the TM1112 and TM1367 proteins from Thermotoga maritima in solution at 298 K were determined following a new protocol which uses the…”
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Automated protein NMR structure determination in crude cell-extract by Etezady-Esfarjani, Touraj, Herrmann, Torsten, Horst, Reto, Wüthrich, Kurt

“…A fully automated, NOE-based NMR structure determination of a uniformly 13C,15N-labeled protein was achieved in crude cell-extract, without purification of the…”
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Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs by Didenko, Tatiana, Liu, Jeffrey J, Horst, Reto, Stevens, Raymond C, Wüthrich, Kurt

“…•Renewed interest in 19F NMR for structural biology of complex molecular systems.•Advances in biochemistry and NMR techniques enable 19F NMR studies of new…”
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NMR Polypeptide Backbone Conformation of the E. coli Outer Membrane Protein W by Horst, Reto, Stanczak, Pawel, Wüthrich, Kurt

“…The outer membrane proteins (Omps) are key factors for bacterial survival and virulence. Among the Omps that have been structurally characterized either by…”
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The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition by Hall, Justin, Ralph, Erik C., Shanker, Suman, Wang, Hong, Byrnes, Laura J., Horst, Reto, Wong, Jimson, Brault, Amy, Dumlao, Darren, Smith, James F., Dakin, Leslie A., Schmitt, Daniel C., Trujillo, John, Vincent, Fabien, Griffor, Matt, Aulabaugh, Ann E.

“…Cyclic GMP‐AMP synthase (cGAS) is activated by ds‐DNA binding to produce the secondary messenger 2′,3′‐cGAMP. cGAS is an important control point in the innate…”
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