Search Results - "Horsley, Alex R"

Effects of Ivacaftor in Patients With Cystic Fibrosis Who Carry the G551D Mutation and Have Severe Lung Disease by Barry, Peter J., MBBCh, Plant, Barry J., MD, Nair, Arjun, MBChB, Bicknell, Stephen, MBChB, Simmonds, Nicholas J., MD, Bell, Nicholas J., MBChB, Shafi, Nadia T., MD, Daniels, Thomas, MD, Shelmerdine, Susan, MBBS, Felton, Imogen, MBBS, Gunaratnam, Cedric, MBBCh, Jones, Andrew M., MD, Horsley, Alex R., PhD

“…BACKGROUND The development of ivacaftor represents a significant advance in therapeutics for patients with cystic fibrosis (CF) who carry the G551D mutation…”
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Evaluation of the impact of alveolar nitrogen excretion on indices derived from multiple breath nitrogen washout by Nielsen, Niklas, Nielsen, Jorgen G, Horsley, Alex R

“…A large body of evidence has now accumulated describing the advantages of multiple breath washout tests over conventional spirometry in cystic fibrosis (CF)…”
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Lung clearance index in healthy volunteers, measured using a novel portable system with a closed circuit wash-in by Horsley, Alex R, Alrumuh, Amnah, Bianco, Brooke, Bayfield, Katie, Tomlinson, Joanne, Jones, Andrew, Maitra, Anirban, Cunningham, Steve, Smith, Jaclyn, Fullwood, Catherine, Pandyan, Anand, Gilchrist, Francis J

“…Lung clearance index (LCI) is a sensitive measure of early lung disease, but adoption into clinical practice has been slow. Challenges include the time taken…”
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Large scale clinical trials: lessons from the COVID-19 pandemic by Horsley, Alex R, Pearmain, Laurence, Knight, Sean, Schindler, Nick, Wang, Ran, Bennett, Miriam, Robey, Rebecca C, Davies, Jane C, Djukanović, Ratko, Heaney, Liam G, Hussell, Tracy, Marciniak, Stefan J, McGarvey, Lorcan P, Porter, Joanna, Wilkinson, Tom, Brightling, Chris, Ho, Ling-Pei

“…BackgroundThe COVID-19 pandemic has presented substantial new challenges to clinical and research teams. Our objective was to analyse the experience of…”
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ERS International Congress 2020: highlights from the Paediatric Assembly by Ardura-Garcia, Cristina, Cuevas-Ocaña, Sara, Freitag, Nadine, Kampouras, Asterios, King, John A, Kouis, Panayiotis, Mensink-Bout, Sara M, Whitehouse, Abigail L, Williams, Emma, Dassios, Theodore, Duijts, Liesbeth, Ersu, Refika H, Gaillard, Erol A, Horsley, Alex R, Proesmans, Marijke, Rottier, Robbert, Schramm, Dirk, Moeller, Alexander, Pijnenburg, Marielle W

“…In this review, the Paediatric Assembly of the European Respiratory Society (ERS) presents a summary of the highlights and most relevant findings in the field…”
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ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly by Nenna, Raffaella, Slaats, Monique, Ersu, Refika, Lo, David, Seglani, Sejal, Nissenbaum, Claire, Horsley, Alex R., Proesmans, Marijke, Petrarca, Laura, Williams, Emma, Dassios, Theodore, Ardura-Garcia, Cristina, Duijts, Liesbeth, Marczak, Honorata, Snijders, Deborah, Rottier, Robbert, Chao, Cho-Ming, Pijnenburg, Marielle W., Grigg, Jonathan

“…In this article, the Group Chairs and the Early Career Members of the Paediatric Assembly of the European Respiratory Society (ERS) highlight some of the most…”
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Closed circuit rebreathing to achieve inert gas wash-in for multiple breath wash-out by Horsley, Alex R, O'Neill, Katherine, Downey, Damian G, Elborn, J Stuart, Bell, Nicholas J, Smith, Jaclyn, Owers-Bradley, John

“…Multiple breath wash-out (MBW) testing requires prior wash-in of inert tracer gas. Wash-in efficiency can be enhanced by a rebreathing tracer in a closed…”
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Longitudinal assessment of lung clearance index to monitor disease progression in children and adults with cystic fibrosis by Horsley, Alex R, Belcher, John, Bayfield, Katie, Bianco, Brooke, Cunningham, Steve, Fullwood, Catherine, Jones, Andrew, Shawcross, Anna, Smith, Jaclyn A, Maitra, Anirban, Gilchrist, Francis J

“…Lung clearance index (LCI) is a valuable research tool in cystic fibrosis (CF) but clinical application has been limited by technical challenges and…”
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Changes in physiological, functional and structural markers of cystic fibrosis lung disease with treatment of a pulmonary exacerbation by Horsley, Alex R, Davies, Jane C, Gray, Robert D, Macleod, Kenneth A, Donovan, Jackie, Aziz, Zelena A, Bell, Nicholas J, Rainer, Margaret, Mt-Isa, Shahrul, Voase, Nia, Dewar, Maria H, Saunders, Clare, Gibson, James S, Parra-Leiton, Javier, Larsen, Mia D, Jeswiet, Sarah, Soussi, Samia, Bakar, Yusura, Meister, Mark G, Tyler, Philippa, Doherty, Ann, Hansell, David M, Ashby, Deborah, Hyde, Stephen C, Gill, Deborah R, Greening, Andrew P, Porteous, David J, Innes, J Alastair, Boyd, A Christopher, Griesenbach, Uta, Cunningham, Steve, Alton, Eric W F W

“…Clinical trials in cystic fibrosis (CF) have been hindered by the paucity of well characterised and clinically relevant outcome measures. To evaluate a range…”
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Effects of cystic fibrosis lung disease on gas mixing indices derived from alveolar slope analysis by Horsley, Alex R, Macleod, Kenneth A, Robson, Andrew G, Lenney, Jill, Bell, Nicholas J, Cunningham, Steve, Greening, Andrew P, Gustafsson, Per M, Innes, J. Alastair

“…Abstract Scond and Sacin are derived from analysis of concentration-normalized phase III slopes (SnIII ) of a multiple breath inert gas washout. Studies in…”
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Discordance between clinical, physiological, and radiological measures in cystic fibrosis by Barry, Peter J., Horsley, Alex R.

“…There are several methods available to the clinician to assess severity of lung disease in cystic fibrosis (CF). Here we present a case where several of these…”
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112 Musculoskeletal symptoms represent a significant burden for adults with cystic fibrosis by Clarke, Elizabeth A, Taylor, Julia, Horsley, Alex R, Jones, Andrew M, Peach, Chris A, Hamid, Abdul, Ho, Pauline, Peckham, Daniel, Freeston, Jane E, Watson, Pippa

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Discordance between clinical, physiological, and radiological measures in cystic fibrosis: Lung function in CF by Barry, Peter J., Horsley, Alex R.

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Lung function in CF by Barry, Peter J, Horsley, Alex R

“…There are several methods available to the clinician to assess severity of lung disease in cystic fibrosis (CF). Here we present a case where several of these…”
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