Potential value of a rapid syndromic multiplex PCR for the diagnosis of native and prosthetic joint infections: a real-world evidence study

: The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). : A study was conducted across 34 clinica...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of bone and joint infection Vol. 9; no. 1; pp. 87 - 97
Main Authors:	Pascual, Stéphanie, Noble, Brooklyn, Ahmad-Saeed, Nusreen, Aldridge, Catherine, Ambretti, Simone, Amit, Sharon, Annett, Rachel, O'Shea, Shaan Ashk, Barbui, Anna Maria, Barlow, Gavin, Barrett, Lucinda, Berth, Mario, Bondi, Alessandro, Boran, Nicola, Boyd, Sara E, Chaves, Catarina, Clauss, Martin, Davies, Peter, Dianzo-Delgado, Ileana T, Esteban, Jaime, Fuchs, Stefan, Friis-Hansen, Lennart, Goldenberger, Daniel, Golle, Andrej, Groonroos, Juha O, Hoffmann, Ines, Hoffmann, Tomer, Hughes, Harriet, Ivanova, Marina, Jezek, Peter, Jones, Gwennan, Ceren Karahan, Zeynep, Lass-Flörl, Cornelia, Laurent, Frédéric, Leach, Laura, Horsbøll Pedersen, Matilde Lee, Loiez, Caroline, Lynch, Maureen, Maloney, Robert J, Marsh, Martin, Milburn, Olivia, Mitchell, Shanine, Moore, Luke S P, Moffat, Lynn, Murdjeva, Marianna, Murphy, Michael E, Nayar, Deepa, Nigrisoli, Giacomo, O'Sullivan, Fionnuala, Öz, Büşra, Peach, Teresa, Petridou, Christina, Prinz, Mojgan, Rak, Mitja, Reidy, Niamh, Rossolini, Gian Maria, Roux, Anne-Laure, Ruiz-Garbajosa, Patricia, Saeed, Kordo, Salar-Vidal, Llanos, Salas Venero, Carlos, Selvaratnam, Mathyruban, Senneville, Eric, Starzengruber, Peter, Talbot, Ben, Taylor, Vanessa, Trebše, Rihard, Wearmouth, Deborah, Willinger, Birgit, Wouthuyzen-Bakker, Marjan, Couturier, Brianne, Allantaz, Florence
Format:	Journal Article
Language:	English
Published:	Germany Copernicus GmbH 28-02-2024 Copernicus Publications
Subjects:	Diagnosis Health aspects Implants, Artificial Infection Original Full-Length Prosthesis
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	: The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). : A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. : A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88.4 % and 85 % respectively between the JI Panel and synovial fluid cultures (SFCs). The JI Panel detected more positive samples and microorganisms than SFC, with a notable difference on , species, , , , and anaerobic bacteria. The study found that the BIOFIRE JI Panel has a high utility in the real-world clinical setting for suspected SA and PJI, providing diagnostic results in approximately 1 h. The user experience was positive, implying a potential benefit of rapidity of results' turnover in optimising patient management strategies. : The study suggests that the BIOFIRE JI Panel could potentially optimise patient management and antimicrobial therapy, thus highlighting its importance in the clinical setting.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2206-3552 2206-3552
DOI:	10.5194/jbji-9-87-2024