Search Results - "Horowitz, Lisa F"

3D-Printed Microfluidics by Au, Anthony K., Huynh, Wilson, Horowitz, Lisa F., Folch, Albert

“…The advent of soft lithography allowed for an unprecedented expansion in the field of microfluidics. However, the vast majority of PDMS microfluidic devices…”
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3D-printed microfluidic automation by Au, Anthony K, Bhattacharjee, Nirveek, Horowitz, Lisa F, Chang, Tim C, Folch, Albert

“…Microfluidic automation - the automated routing, dispensing, mixing, and/or separation of fluids through microchannels - generally remains a slowly-spreading…”
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Olfactory receptor patterning in a higher primate by Horowitz, Lisa F, Saraiva, Luis R, Kuang, Donghui, Yoon, Kyoung-hye, Buck, Linda B

“…The mammalian olfactory system detects a plethora of environmental chemicals that are perceived as odors or stimulate instinctive behaviors. Studies using…”
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Formyl Peptide Receptors Are Candidate Chemosensory Receptors in the Vomeronasal Organ by Liberles, Stephen D., Horowitz, Lisa F., Kuang, Donghui, Contos, James J., Wilson, Kathleen L., Siltberg-Liberles, Jessica, Liberles, David A., Buck, Linda B.

“…The identification of receptors that detect environmental stimuli lays a foundation for exploring the mechanisms and neural circuits underlying sensation. The…”
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Large-scale investigation of the olfactory receptor space using a microfluidic microwell array by Figueroa, Xavier A, Cooksey, Gregory A, Votaw, Scott V, Horowitz, Lisa F, Folch, Albert

“…The mammalian olfactory system is able to discriminate among tens of thousands of odorant molecules. In mice, each odorant is sensed by a small subset of the…”
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Genetic tracing reveals a stereotyped sensory map in the olfactory cortex by Buck, Linda B, Zou, Zhihua, Montmayeur, Jean-Pierre, Snapper, Scott, Horowitz, Lisa F

“…The olfactory system translates myriad chemical structures into diverse odour perceptions. To gain insight into how this is accomplished, we prepared mice that…”
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Drug testing of monodisperse arrays of live microdissected tumors using a valved multiwell microfluidic platform by Lockhart, Ethan J, Horowitz, Lisa F, Rodríguez, Adán, Zhu, Songli, Nguyen, Tran, Mehrabi, Mehdi, Gujral, Taranjit S, Folch, Albert

“…Cancer drug testing in animals is an extremely poor predictor of the drug's safety and efficacy observed in humans. Hence there is a pressing need for…”
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Microdissected "cuboids" for microfluidic drug testing of intact tissues by Horowitz, Lisa F, Rodriguez, Adan D, Au-Yeung, Allan, Bishop, Kevin W, Barner, Lindsey A, Mishra, Gargi, Raman, Aashik, Delgado, Priscilla, Liu, Jonathan T C, Gujral, Taranjit S, Mehrabi, Mehdi, Yang, Mengsu, Pierce, Robert H, Folch, Albert

“…As preclinical animal tests often do not accurately predict drug effects later observed in humans, most drugs under development fail to reach the market. Thus…”
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Muscarinic modulation of erg potassium current by Hirdes, Wiebke, Horowitz, Lisa F., Hille, Bertil

“…We studied modulation of current in human embryonic kidney tsA-201 cells coexpressing rat erg1 channels with M 1 muscarinic receptors. Maximal current was…”
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Organotypic platform for studying cancer cell metastasis by Spennati, Giulia, Horowitz, Lisa F., McGarry, David J., Rudzka, Dominika A., Armstrong, Garett, Olson, Michael F., Folch, Albert, Yin, Huabing

“…Metastasis is the leading cause of mortality in cancer patients. To migrate to distant sites, cancer cells would need to adapt their behaviour in response to…”
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Microfluidics for interrogating live intact tissues by Horowitz, Lisa F., Rodriguez, Adán D., Ray, Tyler, Folch, Albert

“…The intricate microarchitecture of tissues – the “tissue microenvironment” – is a strong determinant of tissue function. Microfluidics offers an invaluable…”
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A Genetic Approach to Trace Neural Circuits by Horowitz, Lisa F., Montmayeur, Jean-Pierre, Echelard, Yann, Buck, Linda B.

“…Mammalian nervous system function involves billions of neurons which are interconnected in a multitude of neural circuits. Here we describe a genetic approach…”
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Label-free, real-time monitoring of cytochrome C drug responses in microdissected tumor biopsies with a multi-well aptasensor platform by Nguyen, Tran N H, Horowitz, Lisa F, Krilov, Timothy, Lockhart, Ethan, Kenerson, Heidi L, Gujral, Taranjit S, Yeung, Raymond S, Arroyo-Currás, Netzahualcóyotl, Folch, Albert

“…Functional assays on intact tumor biopsies can complement genomics-based approaches for precision oncology, drug testing, and organs-on-chips cancer disease…”
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Regulation of KCNQ2/KCNQ3 current by G protein cycling: the kinetics of receptor-mediated signaling by Gq by Suh, Byung-Chang, Horowitz, Lisa F, Hirdes, Wiebke, Mackie, Ken, Hille, Bertil

“…Receptor-mediated modulation of KCNQ channels regulates neuronal excitability. This study concerns the kinetics and mechanism of M1 muscarinic…”
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Genetic tracing reveals a stereotyped sensory map in the olfactory cortex by Zou, Zhihua, Horowitz, Lisa F, Montmayeur, Jean-Pierre, Snapper, Scott, Buck, Linda B

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Mikrofluidik aus dem 3D-Drucker by Au, Anthony K., Huynh, Wilson, Horowitz, Lisa F., Folch, Albert

“…Die Entwicklung der weichen Lithographie hat den Weg bereitet für große Fortschritte auf dem Gebiet der Mikrofluidik. Allerdings ist die Fertigung und der…”
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Phospholipase C in Living Cells by Horowitz, Lisa F., Hirdes, Wiebke, Suh, Byung-Chang, Hilgemann, Donald W., Mackie, Ken, Hille, Bertil

“…We have further tested the hypothesis that receptor-mediated modulation of KCNQ channels involves depletion of phosphatidylinositol 4,5-bisphosphate (PIP2) by…”
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Regulation of KCNQ2/KCNQ3 Current by G Protein Cycling by Suh, Byung-Chang, Horowitz, Lisa F., Hirdes, Wiebke, Mackie, Ken, Hille, Bertil

“…Receptor-mediated modulation of KCNQ channels regulates neuronal excitability. This study concerns the kinetics and mechanism of M1 muscarinic…”
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Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current by Horowitz, Lisa F, Hirdes, Wiebke, Suh, Byung-Chang, Hilgemann, Donald W, Mackie, Ken, Hille, Bertil

“…We have further tested the hypothesis that receptor-mediated modulation of KCNQ channels involves depletion of phosphatidylinositol 4,5-bisphosphate (PIP2) by…”
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585. Multiplexed Gene Transfer To Human T-Cells By Combining Sleeping Beauty Transposon System With Methotrexate Selection by Kcherovsky, Nataly A., Liu, Gary W., Horowitz, Lisa F., Jensen, Michael C., Pun, Suzie H.

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