Search Results - "Hornyák, Péter"

The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function by Breslin, Claire, Hornyak, Peter, Ridley, Andrew, Rulten, Stuart L, Hanzlikova, Hana, Oliver, Antony W, Caldecott, Keith W

“…Poly (ADP-ribose) is synthesized at DNA single-strand breaks and can promote the recruitment of the scaffold protein, XRCC1. However, the mechanism and…”
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Chlorotoxin binds to both matrix metalloproteinase 2 and neuropilin 1 by Farkas, Sándor, Cioca, Daniel, Murányi, József, Hornyák, Péter, Brunyánszki, Attila, Szekér, Patrik, Boros, Eszter, Horváth, Patrik, Hujber, Zoltán, Rácz, Gábor Z., Nagy, Noémi, Tóth, Rebeka, Nyitray, László, Péterfi, Zalán

“…Chlorotoxin (CTX), a scorpion venom–derived 36-residue miniprotein, binds to and is taken up selectively by glioblastoma cells. Previous studies provided…”
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Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1 by Polo, Luis M., Xu, Yingqi, Hornyak, Peter, Garces, Fernando, Zeng, Zhihong, Hailstone, Richard, Matthews, Steve J., Caldecott, Keith W., Oliver, Antony W., Pearl, Laurence H.

“…XRCC1 accelerates repair of DNA single-strand breaks by acting as a scaffold protein for the recruitment of Polβ, LigIIIα, and end-processing factors, such as…”
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KcsA-Kv1.x chimeras with complete ligand-binding sites provide improved predictivity for screening selective Kv1.x blockers by Szekér, Patrik, Bodó, Tamás, Klima, Katalin, Csóti, Ágota, Hanh, Nikoletta Ngo, Murányi, József, Hajdara, Anna, Szántó, Tibor Gábor, Panyi, György, Megyeri, Márton, Péterfi, Zalán, Farkas, Sándor, Gyöngyösi, Norbert, Hornyák, Péter

“…Despite significant advances in the development of therapeutic interventions targeting autoimmune diseases and chronic inflammatory conditions, lack of…”
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14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface by Karlberg, Tobias, Hornyak, Peter, Pinto, Ana Filipa, Milanova, Stefina, Ebrahimi, Mahsa, Lindberg, Mikael, Püllen, Nikolai, Nordström, Axel, Löverli, Elinor, Caraballo, Rémi, Wong, Emily V., Näreoja, Katja, Thorsell, Ann-Gerd, Elofsson, Mikael, De La Cruz, Enrique M., Björkegren, Camilla, Schüler, Herwig

“…Pseudomonas are a common cause of hospital-acquired infections that may be lethal. ADP-ribosyltransferase activities of Pseudomonas exotoxin-S and -T depend on…”
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Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2 by Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E, Bartlett, Edward J, Brissett, Nigel C, Raoof, Ali, Watson, Mandy, Jordan, Allan M, Ogilvie, Donald J, Ward, Simon E, Atack, John R, Pearl, Laurence H, Caldecott, Keith W, Oliver, Antony W

“…Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a 5'-tyrosyl DNA phosphodiesterase important for the repair of DNA adducts generated by non-productive (abortive)…”
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14-3-3 Activated Bacterial Exotoxins AexT and ExoT Share Actin and the SH2 Domains of CRK Proteins as Targets for ADP-Ribosylation by Ebenwaldner, Carmen, Hornyak, Peter, García-Saura, Antonio Ginés, Torretta, Archimede, Anoosheh, Saber, Hofer, Anders, Schüler, Herwig

“…Bacterial exotoxins with ADP-ribosyltransferase activity can be divided into distinct clades based on their domain organization. Exotoxins from several clades…”
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XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia by Hoch, Nicolas C., Hanzlikova, Hana, Rulten, Stuart L., Tétreault, Martine, Komulainen, Emilia, Ju, Limei, Hornyak, Peter, Zeng, Zhihong, Gittens, William, Rey, Stephanie A., Staras, Kevin, Mancini, Grazia M. S., McKinnon, Peter J., Wang, Zhao-Qi, Wagner, Justin D., Yoon, Grace, Caldecott, Keith W.

“…Biallelic mutations in human XRCC1 are associated with ocular motor apraxia, axonal neuropathy, and progressive cerebellar ataxia. Cerebellar ataxia link to…”
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Structural and mechanistic studies of dna repair proteins by Hornyak, Peter

“…Project 1: Small molecule inhibitors of TDP2 DNA Topoisomerase II (TOP2) has important roles in many cellular processes such as DNA replication and…”
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Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase by Cole, Ambrose R, Ofer, Sapir, Ryzhenkova, Ksenia, Baltulionis, Gediminas, Hornyak, Peter, Savva, Renos

“…Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to…”
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