Search Results - "Horning, Kyle J"

Manganese Is Essential for Neuronal Health by Horning, Kyle J, Caito, Samuel W, Tipps, K. Grace, Bowman, Aaron B, Aschner, Michael

“…The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an…”
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Patterns of developmental regression and associated clinical characteristics in SLC6A1-related disorder by Kalvakuntla, Sanjana, Lee, MinJae, Chung, Wendy K, Demarest, Scott, Freed, Amber, Horning, Kyle J, Bichell, Terry Jo, Iannaccone, Susan T, Goodspeed, Kimberly

“…SLC6A1-related disorder is a genetic neurodevelopmental disorder that is caused by loss of function variants in the gene. Solute Carrier Family 6 Member 1 ( )…”
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Identification of Three Small Molecules That Can Selectively Influence Cellular Manganese Levels in a Mouse Striatal Cell Model by Horning, Kyle J, Tang, Xueqi, Thomas, Morgan G, Aschner, Michael, Bowman, Aaron B

“…Manganese (Mn) is a biologically essential metal, critical as a cofactor for numerous enzymes such a glutamine synthetase and kinases such as…”
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A Small-Molecule Modulator of Metal Homeostasis in Gram-Positive Pathogens by Juttukonda, Lillian J, Beavers, William N, Unsihuay, Daisy, Kim, Kwangho, Pishchany, Gleb, Horning, Kyle J, Weiss, Andy, Al-Tameemi, Hassan, Boyd, Jeffrey M, Sulikowski, Gary A, Bowman, Aaron B, Skaar, Eric P

“…Metals are essential nutrients that all living organisms acquire from their environment. While metals are necessary for life, excess metal uptake can be toxic;…”
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A disease concept model for STXBP1‐related disorders by Sullivan, Katie R., Ruggiero, Sarah M., Xian, Julie, Thalwitzer, Kim M., Ali, Rahma, Stewart, Sydni, Cosico, Mahgenn, Steinberg, Jackie, Goss, James, Pfalzer, Anna C., Horning, Kyle J., Weitzel, Nicole, Corey, Sydney, Conway, Laura, Rigby, Charlene Son, Bichell, Terry Jo, Helbig, Ingo

“…Objective STXBP1‐related disorders are rare genetic epilepsies and neurodevelopmental disorders, but the impact of symptoms across clinical domains is poorly…”
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Role of d‐amino acid oxidase in the production of kynurenine pathway metabolites from d‐tryptophan in mice by Notarangelo, Francesca M., Wang, Xiao‐Dan, Horning, Kyle J., Schwarcz, Robert

“…The kynurenine pathway (KP), the major catabolic route of the essential amino acid l‐tryptophan (l‐TRP), contains several neuroactive compounds, including…”
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Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese by Horning, Kyle J., Joshi, Piyush, Nitin, Rachana, Balachandran, Rekha C., Yanko, Frank M., Kim, Kwangho, Christov, Plamen, Aschner, Michael, Sulikowski, Gary A., Weaver, C. David, Bowman, Aaron B.

“…Available assays for measuring cellular manganese (Mn) levels require cell lysis, restricting longitudinal experiments and multiplexed outcome measures…”
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Small Molecule Modifiers of In Vitro Manganese Transport Alter Toxicity In Vivo by Peres, Tanara V., Horning, Kyle J., Bornhorst, Julia, Schwerdtle, Tanja, Bowman, Aaron B., Aschner, Michael

“…Manganese (Mn) is essential for several species and daily requirements are commonly met by an adequate diet. Mn overload may cause motor and psychiatric…”
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Sigma‐1 receptor ligands inhibit catecholamine secretion from adrenal chromaffin cells due to block of nicotinic acetylcholine receptors by Brindley, Rebecca L., Bauer, Mary Beth, Hartley, Nolan D., Horning, Kyle J., Currie, Kevin P.M.

“…Adrenal chromaffin cells (ACCs) are the neuroendocrine arm of the sympathetic nervous system and key mediators of the physiological stress response…”
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A method for the determination of d-kynurenine in biological tissues by Wang, Xiao-Dan, Horning, Kyle J., Notarangelo, Francesca M., Schwarcz, Robert

“…d -Kynurenine ( d -KYN), a metabolite of d -tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine, two neuroactive…”
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