Search Results - "Horne, I"

Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers by Ruggeri, Francesco Simone, Habchi, Johnny, Chia, Sean, Horne, Robert I., Vendruscolo, Michele, Knowles, Tuomas P. J.

“…Significant efforts have been devoted in the last twenty years to developing compounds that can interfere with the aggregation pathways of proteins related to…”
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A rapid in vivo pipeline to identify small molecule inhibitors of amyloid aggregation by Kamal, Muntasir, Knox, Jessica, Horne, Robert I., Tiwari, Om Shanker, Burns, Andrew R., Han, Duhyun, Levy, Davide, Laor Bar-Yosef, Dana, Gazit, Ehud, Vendruscolo, Michele, Roy, Peter J.

“…Amyloids are associated with over 50 human diseases and have inspired significant effort to identify small molecule remedies. Here, we present an in vivo…”
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Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation by Staats, Roxine, Brotzakis, Z. Faidon, Chia, Sean, Horne, Robert I., Vendruscolo, Michele

“…Parkinson’s disease is characterised by the deposition in the brain of amyloid aggregates of α-synuclein. The surfaces of these amyloid aggregates can catalyse…”
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Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter by Staats, Roxine, Michaels, Thomas C. T., Flagmeier, Patrick, Chia, Sean, Horne, Robert I., Habchi, Johnny, Linse, Sara, Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele

“…The aggregation of α-synuclein is a central event in Parkinsons’s disease and related synucleinopathies. Since pharmacologically targeting this process,…”
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Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling by Naugle, Jennifer E, Olson, Erik R, Zhang, Xiaojin, Mase, Sharon E, Pilati, Charles F, Maron, Michael B, Folkesson, Hans G, Horne, Walter I, Doane, Kathleen J, Meszaros, J Gary

“…Cardiac fibroblast (CF) proliferation and differentiation into hypersecretory myofibroblasts can lead to excessive extracellular matrix (ECM) production and…”
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53‐2: Invited Paper: Flexible LCDs Enabled by OTFT by Harding, M. James, Horne, I. P., Yaglioglu, B.

“…We report data of organic transistors on plastic with mobility values greater than 1cm2 /Vs. This technology enables LCDs that are thin, lightweight,…”
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Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors by Chandra, Raghav, Horne, Robert I., Vendruscolo, Michele

“…The process of drug design requires the initial identification of compounds that bind their targets with high affinity and selectivity. Advances in generative…”
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The effects of hypothyroidism on the proximal femoral physis in miniature swine by Tank, Jason C., Weiner, Dennis S., Jacquet, Robin, Childs, Dylan, Ritzman, Todd F., Horne, Walter I., Steiner, Richard, Morscher, Melanie A., Landis, William J.

“…ABSTRACT As a potential means of comparing hypothyroidism in humans, this work intended to establish a defined hypothyroid state in immature miniature swine…”
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ENZYMATIC BIOREMEDIATION: FROM ENZYME DISCOVERY TO APPLICATIONS by Sutherland, TD, Horne, I, Weir, KM, Coppin, CW, Williams, MR, Selleck, M, Russell, RJ, Oakeshott, JG

“…SUMMARY 1. Enzymatic bioremediation is potentially a rapid method of removing environmental pesticide residues. Applications include the treatment of residues…”
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A Study in Vivo of the Effects of a Static Compressive Load on the Proximal Tibial Physis in Rabbits by Bries, Andrew D, Weiner, Dennis S, Jacquet, Robin, Adamczyk, Mark J, Morscher, Melanie A, Lowder, Elizabeth, Askew, Michael J, Steiner, Richard P, Horne, Walter I, Landis, William J

“…BACKGROUND:The effect of compression on the physis is generally defined by the Hueter-Volkmann principle, in which decreased linear growth of the physis…”
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Isolation and functional characterization of two independently-evolved fatty acid Δ12-desaturase genes from insects by Zhou, X.-R., Horne, I., Damcevski, K., Haritos, V., Green, A., Singh, S.

“…We report the first isolation and characterization of insect fatty acid Δ12‐desaturase genes, AdD12Des from house cricket (Acheta domesticus) and TcD12Des from…”
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Direct comparison of fluorescence- and bioluminescence-based resonance energy transfer methods for real-time monitoring of thrombin-catalysed proteolytic cleavage by Dacres, H., Dumancic, M.M., Horne, I., Trowell, S.C.

“…In this study, a representative FRET system (CFP donor and YFP acceptor) is compared with the BRET 2 system ( Renilla luciferase donor, green fluorescent…”
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Evolution of an organophosphate-degrading enzyme: a comparison of natural and directed evolution by Yang, H., Carr, P.D., McLoughlin, S.Yu, Liu, J.W., Horne, I., Qiu, X., Jeffries, C.M.J., Russell, R.J., Oakeshott, J.G., Ollis, D.L.

“…Organophosphate-degrading enzyme from Agrobacterium radiobacter P230 (OPDA) is a recently discovered enzyme that degrades a broad range of organophosphates. It…”
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The p53 DNA damage response and Fanconi anemia DNA repair pathway protect against acetaldehyde-induced replication stress in esophageal keratinocytes by Peake, Jasmine D, Horne, Kalisse I, Noguchi, Chiaki, Gilligan, John P, Noguchi, Eishi

“…Alcohol contributes to cellular accumulation of acetaldehyde, a primary metabolite of alcohol and a major human carcinogen. Acetaldehyde can form DNA adducts…”
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Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α‑Synuclein Secondary Nucleation by Horne, Robert I., Murtada, Mhd Hussein, Huo, Donghui, Brotzakis, Z. Faidon, Gregory, Rebecca C., Possenti, Andrea, Chia, Sean, Vendruscolo, Michele

“…The high attrition rate in drug discovery pipelines is an especially pressing issue for Parkinson’s disease, for which no disease-modifying drugs have yet been…”
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Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity by Horne, Robert I., Wilson-Godber, Jared, González Díaz, Alicia, Brotzakis, Z. Faidon, Seal, Srijit, Gregory, Rebecca C., Possenti, Andrea, Chia, Sean, Vendruscolo, Michele

“…In the early stages of drug development, large chemical libraries are typically screened to identify compounds of promising potency against the chosen targets…”
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The influence of experimental manipulations on chewing speed during in vivo laboratory research in tufted capuchins (Cebus apella) by Thompson, C.L., Donley, E.M., Stimpson, C.D., Horne, W.I., Vinyard, C.J.

“…Even though in vivo studies of mastication in living primates are often used to test functional and adaptive hypotheses explaining primate masticatory…”
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Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α‑Synuclein Aggregates by Chia, Sean, Faidon Brotzakis, Z., Horne, Robert I., Possenti, Andrea, Mannini, Benedetta, Cataldi, Rodrigo, Nowinska, Magdalena, Staats, Roxine, Linse, Sara, Knowles, Tuomas P. J., Habchi, Johnny, Vendruscolo, Michele

“…The presence of amyloid fibrils of α-synuclein is closely associated with Parkinson’s disease and related synucleinopathies. It is still very challenging,…”
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Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores by Sandler, Sarah E, Horne, Robert I, Rocchetti, Sara, Novak, Robert, Hsu, Nai-Shu, Castellana Cruz, Marta, Faidon Brotzakis, Z, Gregory, Rebecca C, Chia, Sean, Bernardes, Gonçalo J L, Keyser, Ulrich F, Vendruscolo, Michele

“…Misfolded protein oligomers are of central importance in both the diagnosis and treatment of Alzheimer's and Parkinson's diseases. However, accurate…”
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Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning by Horne, Robert I., Andrzejewska, Ewa A., Alam, Parvez, Brotzakis, Z. Faidon, Srivastava, Ankit, Aubert, Alice, Nowinska, Magdalena, Gregory, Rebecca C., Staats, Roxine, Possenti, Andrea, Chia, Sean, Sormanni, Pietro, Ghetti, Bernardino, Caughey, Byron, Knowles, Tuomas P. J., Vendruscolo, Michele

“…Machine learning methods hold the promise to reduce the costs and the failure rates of conventional drug discovery pipelines. This issue is especially pressing…”
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