Search Results - "Hornburg, Daniel"

Nano–Bio Interactions in Cancer: From Therapeutics Delivery to Early Detection by Liu, Yuan, Wang, Junqing, Xiong, Qingqing, Hornburg, Daniel, Tao, Wei, Farokhzad, Omid C

“…Conspectus Understanding the interactions between nanomaterials and biological systems plays a pivotal role in enhancing the efficacy of nanomedicine and…”
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Social network architecture of human immune cells unveiled by quantitative proteomics by Rieckmann, Jan C, Geiger, Roger, Hornburg, Daniel, Wolf, Tobias, Kveler, Ksenya, Jarrossay, David, Sallusto, Federica, Shen-Orr, Shai S, Lanzavecchia, Antonio, Mann, Matthias, Meissner, Felix

“…Immune cells give rise to the most interconnected system in the body. Meissner and colleagues perform comprehensive proteomics and secretomics to describe in…”
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Longitudinal multi-omics of host–microbe dynamics in prediabetes by Zhou, Wenyu, Sailani, M. Reza, Contrepois, Kévin, Zhou, Yanjiao, Ahadi, Sara, Leopold, Shana R., Zhang, Martin J., Rao, Varsha, Avina, Monika, Mishra, Tejaswini, Johnson, Jethro, Lee-McMullen, Brittany, Chen, Songjie, Metwally, Ahmed A., Tran, Thi Dong Binh, Nguyen, Hoan, Zhou, Xin, Albright, Brandon, Hong, Bo-Young, Petersen, Lauren, Bautista, Eddy, Hanson, Blake, Chen, Lei, Spakowicz, Daniel, Bahmani, Amir, Salins, Denis, Leopold, Benjamin, Ashland, Melanie, Dagan-Rosenfeld, Orit, Rego, Shannon, Limcaoco, Patricia, Colbert, Elizabeth, Allister, Candice, Perelman, Dalia, Craig, Colleen, Wei, Eric, Chaib, Hassan, Hornburg, Daniel, Dunn, Jessilyn, Liang, Liang, Rose, Sophia Miryam Schüssler-Fiorenza, Kukurba, Kim, Piening, Brian, Rost, Hannes, Tse, David, McLaughlin, Tracey, Sodergren, Erica, Weinstock, George M., Snyder, Michael

“…Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the…”
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Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool by Jordan, Stefan, Tung, Navpreet, Casanova-Acebes, Maria, Chang, Christie, Cantoni, Claudia, Zhang, Dachuan, Wirtz, Theresa H., Naik, Shruti, Rose, Samuel A., Brocker, Chad N., Gainullina, Anastasiia, Hornburg, Daniel, Horng, Sam, Maier, Barbara B., Cravedi, Paolo, LeRoith, Derek, Gonzalez, Frank J., Meissner, Felix, Ochando, Jordi, Rahman, Adeeb, Chipuk, Jerry E., Artyomov, Maxim N., Frenette, Paul S., Piccio, Laura, Berres, Marie-Luise, Gallagher, Emily J., Merad, Miriam

“…Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation…”
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Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona by Blume, John E., Manning, William C., Troiano, Gregory, Hornburg, Daniel, Figa, Michael, Hesterberg, Lyndal, Platt, Theodore L., Zhao, Xiaoyan, Cuaresma, Rea A., Everley, Patrick A., Ko, Marwin, Liou, Hope, Mahoney, Max, Ferdosi, Shadi, Elgierari, Eltaher M., Stolarczyk, Craig, Tangeysh, Behzad, Xia, Hongwei, Benz, Ryan, Siddiqui, Asim, Carr, Steven A., Ma, Philip, Langer, Robert, Farias, Vivek, Farokhzad, Omid C.

“…Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma proteome. Here we report a highly parallel protein quantitation…”
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C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration by May, Stephanie, Hornburg, Daniel, Schludi, Martin H., Arzberger, Thomas, Rentzsch, Kristin, Schwenk, Benjamin M., Grässer, Friedrich A., Mori, Kohji, Kremmer, Elisabeth, Banzhaf-Strathmann, Julia, Mann, Matthias, Meissner, Felix, Edbauer, Dieter

“…Hexanucleotide repeat expansion in C9orf72 is the most common pathogenic mutation in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…”
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Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans by Lancaster, Samuel M., Lee-McMullen, Brittany, Abbott, Charles Wilbur, Quijada, Jeniffer V., Hornburg, Daniel, Park, Heyjun, Perelman, Dalia, Peterson, Dylan J., Tang, Michael, Robinson, Aaron, Ahadi, Sara, Contrepois, Kévin, Hung, Chia-Jui, Ashland, Melanie, McLaughlin, Tracey, Boonyanit, Anna, Horning, Aaron, Sonnenburg, Justin L., Snyder, Michael P.

“…Dietary fibers act through the microbiome to improve cardiovascular health and prevent metabolic disorders and cancer. To understand the health benefits of…”
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Evidence of Extrapancreatic Glucagon Secretion in Man by Lund, Asger, Bagger, Jonatan I, Wewer Albrechtsen, Nicolai J, Christensen, Mikkel, Grøndahl, Magnus, Hartmann, Bolette, Mathiesen, Elisabeth R, Hansen, Carsten P, Storkholm, Jan H, van Hall, Gerrit, Rehfeld, Jens F, Hornburg, Daniel, Meissner, Felix, Mann, Matthias, Larsen, Steen, Holst, Jens J, Vilsbøll, Tina, Knop, Filip K

“…Glucagon is believed to be a pancreas-specific hormone, and hyperglucagonemia has been shown to contribute significantly to the hyperglycemic state of patients…”
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Molecular and structural architecture of polyQ aggregates in yeast by Gruber, Anselm, Hornburg, Daniel, Antonin, Matthias, Krahmer, Natalie, Collado, Javier, Schaffer, Miroslava, Zubaite, Greta, Lüchtenborg, Christian, Sachsenheimer, Timo, Brügger, Britta, Mann, Matthias, Baumeister, Wolfgang, Hartl, F. Ulrich, Hipp, Mark S., Fernández-Busnadiego, Rubén

“…Huntington’s disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-terminal exon of huntingtin (HttEx1), but the cellular mechanisms…”
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Deep Proteomic Evaluation of Primary and Cell Line Motoneuron Disease Models Delineates Major Differences in Neuronal Characteristics by Hornburg, Daniel, Drepper, Carsten, Butter, Falk, Meissner, Felix, Sendtner, Michael, Mann, Matthias

“…The fatal neurodegenerative disorders amyotrophic lateral sclerosis and spinal muscular atrophy are, respectively, the most common motoneuron disease and…”
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Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight by Houerbi, Nadia, Kim, JangKeun, Overbey, Eliah G., Batra, Richa, Schweickart, Annalise, Patras, Laura, Lucotti, Serena, Ryon, Krista A., Najjar, Deena, Meydan, Cem, Damle, Namita, Chin, Christopher, Narayanan, S. Anand, Guarnieri, Joseph W., Widjaja, Gabrielle, Beheshti, Afshin, Tobias, Gabriel, Vatter, Fanny, Hirschberg, Jeremy Wain, Kleinman, Ashley, Afshin, Evan E., MacKay, Matthew, Chen, Qiuying, Miller, Dawson, Gajadhar, Aaron S., Williamson, Lucy, Tandel, Purvi, Yang, Qiu, Chu, Jessica, Benz, Ryan, Siddiqui, Asim, Hornburg, Daniel, Gross, Steven, Shirah, Bader, Krumsiek, Jan, Mateus, Jaime, Mao, Xiao, Matei, Irina, Mason, Christopher E.

“…As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By…”
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Identification of covalent modifications regulating immune signaling complex composition and phenotype by Frauenstein, Annika, Ebner, Stefan, Hansen, Fynn M, Sinha, Ankit, Phulphagar, Kshiti, Swatek, Kirby, Hornburg, Daniel, Mann, Matthias, Meissner, Felix

“…Cells signal through rearrangements of protein communities governed by covalent modifications and reversible interactions of distinct sets of proteins. A…”
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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity by Hartmann, Hannelore, Hornburg, Daniel, Czuppa, Mareike, Bader, Jakob, Michaelsen, Meike, Farny, Daniel, Arzberger, Thomas, Mann, Matthias, Meissner, Felix, Edbauer, Dieter

“…Frontotemporal dementia and amyotrophic lateral sclerosis patients with mutation show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and…”
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TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons by Schwenk, Benjamin M, Hartmann, Hannelore, Serdaroglu, Alperen, Schludi, Martin H, Hornburg, Daniel, Meissner, Felix, Orozco, Denise, Colombo, Alessio, Tahirovic, Sabina, Michaelsen, Meike, Schreiber, Franziska, Haupt, Simone, Peitz, Michael, Brüstle, Oliver, Küpper, Clemens, Klopstock, Thomas, Otto, Markus, Ludolph, Albert C, Arzberger, Thomas, Kuhn, Peer-Hendrik, Edbauer, Dieter

“…Nuclear clearance of TDP‐43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…”
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Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls by Margaret K R Donovan, Yingxiang Huang, John E Blume, Jian Wang, Daniel Hornburg, Shadi Ferdosi, Iman Mohtashemi, Sangtae Kim, Marwin Ko, Ryan W Benz, Theodore L Platt, Serafim Batzoglou, Luis A Diaz, Omid C Farokhzad, Asim Siddiqui

“…Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers…”
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Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls by Donovan, Margaret K R, Huang, Yingxiang, Blume, John E, Wang, Jian, Hornburg, Daniel, Ferdosi, Shadi, Mohtashemi, Iman, Kim, Sangtae, Ko, Marwin, Benz, Ryan W, Platt, Theodore L, Batzoglou, Serafim, Diaz, Luis A, Farokhzad, Omid C, Siddiqui, Asim

“…Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers…”
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A Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Markers Using ProteographTM and Trapped Ion Mobility Mass Spectrometry by Chang, Matthew E. K., Lange, Jane, Cartier, Jessie May, Moore, Travis W., Soriano, Sophia M., Albracht, Brenna, Krawitzky, Michael, Guturu, Harendra, Alavi, Amir, Stukalov, Alexey, Zhou, Xiaoyuan, Elgierari, Eltaher M., Chu, Jessica, Benz, Ryan, Cuevas, Juan C., Ferdosi, Shadi, Hornburg, Daniel, Farokhzad, Omid, Siddiqui, Asim, Batzoglou, Serafim, Leach, Robin J., Liss, Michael A., Kopp, Ryan P., Flory, Mark R.

“…There is a significant unmet need for clinical reflex tests that increase the specificity of prostate-specific antigen blood testing, the longstanding but…”
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Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome by Ripaud, Leslie, Chumakova, Victoria, Antonin, Matthias, Hastie, Alex R., Pinkert, Stefan, Kömer, Roman, Ruff, Kiersten M., Pappu, Rohit V., Hornburg, Daniel, Mann, Matthias, Hartl, F. Ulrich, Hipp, Mark S.

“…Expansion of a poly-glutamine (polyQ) repeat in a group of functionally unrelated proteins is the cause of several inherited neurodegenerative disorders,…”
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production by Wewer Albrechtsen, Nicolai J., Kuhre, Rune E., Hornburg, Daniel, Jensen, Christian Z., Hornum, Mads, Dirksen, Carsten, Svane, Maria, Gasbjerg, Lærke S., Jørgensen, Nils B., Gabe, Maria N., Balk-Møller, Emilie, Albrechtsen, Reidar, Winther-Sørensen, Marie, Galsgaard, Katrine D., Meissner, Felix, Jorsal, Tina, Lund, Asger, Vilsbøll, Tina, Eliasen, Rasmus, Bojsen-Møller, Kirstine N., Idorn, Thomas, Deacon, Carolyn F., Knop, Filip K., Rosenkilde, Mette M., Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten, Holst, Jens J.

“…Glucagon is secreted from pancreatic α cells, and hypersecretion (hyperglucagonemia) contributes to diabetic hyperglycemia. Molecular heterogeneity…”
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Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma by Wewer Albrechtsen, Nicolai J., Hornburg, Daniel, Albrechtsen, Reidar, Svendsen, Berit, Toräng, Signe, Jepsen, Sara L., Kuhre, Rune E., Hansen, Marie, Janus, Charlotte, Floyd, Andrea, Lund, Asger, Vilsbøll, Tina, Knop, Filip K., Vestergaard, Henrik, Deacon, Carolyn F., Meissner, Felix, Mann, Matthias, Holst, Jens J., Hartmann, Bolette

“…Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined…”
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