Search Results - "Hornbrook, K R"

Serum and liver concentrations of tumor necrosis factor α and interleukin-1 β following administration of carbon tetrachloride to male rats by DeCicco, Lacinda A, Rikans, Lora E, Tutor, Carrie G, Hornbrook, K.Roger

“…Inflammatory cytokines are recognized as early mediators of tissue damage and repair. The purpose of this study was to determine the effects of carbon…”
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Lipid peroxidation, antioxidant protection and aging by Rikans, Lora E, Hornbrook, K.Roger

“…The free radical hypothesis of aging proposes that deleterious actions of oxygen-derived radicals are responsible for the functional deterioration associated…”
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Age and gender differences in hepatic ascorbic acid concentrations and NADPH-dehydroascorbic acid reductase activity by Rikans, Lora E., Lopez, Tony R., Hornbrook, K.Roger

“…Ascorbic acid content decreased with age in livers of male rats but not in those of female rats. The influence of aging on the regeneration of ascorbic acid…”
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Carbon tetrachloride hepatotoxicity as a function of age in female Fischer 344 rats by Rikans, L E, Hornbrook, K R, Cai, Y

“…Severity of liver damage 24 h after intraperitoneal administration of carbon tetrachloride (0.2 ml/kg) was evaluated in female Fischer 344 rats aged 5, 14 and…”
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Thiol-disulfide exchange systems in the liver of aging Fischer 344 rats by Rikans, L E, Hornbrook, K R

“…The purpose of this study was to determine whether the major thiol-disulfide oxidoreductase activities of the rat liver were altered as a consequence of aging,…”
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Oxidation of pyridine nucleotides is an early event in the lethality of allyl alcohol by Rikans, Lora E., Cai, David Y., Hornbrook, K.Roger

“…The involvement of altered pyridine nucleotide concentrations in the cytolethality of allyl alcohol was studied in isolated rat hepatocytes. NAD +, NADH, NADP…”
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Aged mice are resistant to the hepatotoxic effects of endotoxin and galactosamine by Hornbrook, K R, Kosanke, S D, Rikans, L E

“…The ability of concurrent intraperitoneal injections of endotoxin (0.1 micrograms/kg) and galactosamine (700 mg/kg) to produce liver damage was determined in…”
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Allyl alcohol cytotoxicity in isolated rat hepatocytes : mechanism of cell death does not involve an early rise in cytosolic free calcium by RIKANS, L. E, TONG CAI, HORNBROOK, K. R

“…We examined the effect of a toxic concentration of allyl alcohol (0.5 mM) on intracellular calcium concentrations in isolated rat hepatocytes. An increase in…”
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Lipid peroxidation and alteration of membrane lipids in isolated hepatocytes exposed to carbon tetrachloride by Weddle, C C, Hornbrook, K R, McCay, P B

“…Lipid peroxidation, determined by malondialdehyde formation, occurs at a low, but detectable, rate in parenchymal cells isolated from livers of fasted rats…”
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Allyl alcohol cytotoxicity in isolated rat hepatocytes: effects of azide, fasting, and fructose by Rikans, L E, Cai, Y, Hornbrook, K R

“…The role of altered energy homeostasis in the lethality of allyl alcohol to isolated rat hepatocytes was studied. ATP, ADP, AMP, and viability loss (leakage of…”
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Isolated hepatocytes as a model for aging effects on hepatotoxicity: studies with allyl alcohol by Rikans, L E, Hornbrook, K R

“…The influence of aging on the toxicity of allyl alcohol was studied in hepatocytes isolated from male Fischer 344 rats. Initial values for trypan blue uptake,…”
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Adenylate cyclase activity and motor behavior following cerebral ischemia in the unanesthetized gerbil by Chandler, M J, Hornbrook, K R, Carney, J M

“…Five minutes of bilateral carotid occlusion in unanesthetized gerbils produced substantial changes in spontaneous locomotor activity. Behavior was decreased…”
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The effects of adrenalectomy and hydrocortisone on rat liver metabolites and glycogen synthetase activity by Hornbrook, K R, Burch, H B, Lowry, O H

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Effects of carbon tetrachloride on the metabolism of liver glycogen in the rat by Hickenbottom, R S, Hornbrook, K R

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Synthesis of liver glycogen in starved alloxan diabetic rats by Hornbrook, K R

“…Alloxan diabetic rats are considered unable to synthesize liver glycogen because of a low activity of glycogen synthetase. The present report shows, however,…”
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Effect of age and carbon tetrachloride on cytokine concentrations in rat liver by Rikans, Lora E., DeCicco, Lacinda A., Hornbrook, K.Roger, Yamano, Tetsuo

“…Interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) concentrations were measured in livers of young-adult and old rats…”
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Enhancement by thyroid hormone treatment of norepinephrine-induced phosphorylase activation in the rat heart by Hornbrook, K R, Cabral, A

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Effects of adrenergic agents on carbohydrate metabolism of rat liver: activities of adenyl cyclase and glycogen phosphorylase by Newton, N E, Hornbrook, K R

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Adrenergic receptors for metabolic responses in the liver by Hornbrook, K R

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Age-Associated Increase in Ferritin Content of Male Rat Liver: Implication for Diquat-Mediated Oxidative Injury by Rikans, Lora E., Ardinska, Vita, Hornbrook, K.Roger

“…Our previous studies in rat hepatocytes demonstrated an age-dependent increase in sensitivity to diquat-induced cytotoxicity, possibly as a result of increased…”
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