Search Results - "Horn, Lars Christian"

Surgical resection based on ontogenetic cancer field theory for cervical cancer: mature results from a single-centre, prospective, observational, cohort study by Höckel, Michael, Prof, Wolf, Benjamin, MD, Schmidt, Katja, RN, Mende, Meinhard, PhD, Aktas, Bahriye, Prof, Kimmig, Rainer, Prof, Dornhöfer, Nadja, MD, Horn, Lars-Christian, Professor

“…SummaryBackgroundPrevious findings from our centre suggest that carcinoma of the cervix propagates within ontogenetic cancer fields, tissue compartments…”
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Cell and Nucleus Shape as an Indicator of Tissue Fluidity in Carcinoma by Grosser, Steffen, Lippoldt, Jürgen, Oswald, Linda, Merkel, Matthias, Sussman, Daniel M., Renner, Frédéric, Gottheil, Pablo, Morawetz, Erik W., Fuhs, Thomas, Xie, Xiaofan, Pawlizak, Steve, Fritsch, Anatol W., Wolf, Benjamin, Horn, Lars-Christian, Briest, Susanne, Aktas, Bahriye, Manning, M. Lisa, Käs, Josef A.

“…Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell cultures, different tissue states, such as fluid (unjammed) and…”
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Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma by Horn, Lars-Christian, Höhn, Anne Kathrin, Krücken, Irene, Stiller, Mathias, Obeck, Ulrike, Brambs, Christine E.

“…Purpose Endometrial mesonephric-like adenocarcinoma (ML-AC) represents a recently recognized subtype of endometrial adenocarcinoma (AC) associated with a…”
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Vulvar field resection based on ontogenetic cancer field theory for surgical treatment of vulvar carcinoma: a single-centre, single-group, prospective trial by Höckel, Michael, Trott, Sophia, Dornhöfer, Nadja, Horn, Lars-Christian, Hentschel, Bettina, Wolf, Benjamin

“…The incidence of vulvar cancer is increasing, but surgical treatment—the current standard of care—often leads to unsatisfactory outcomes, especially in…”
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High concordance of molecular subtyping between pre-surgical biopsy and surgical resection specimen (matched-pair analysis) in patients with vulvar squamous cell carcinoma using p16- and p53-immunostaining by Höhn, Anne Kathrin, Forberger, Mirjam, Alfaraidi, Mona, Gilks, C. Blake, Brambs, Christine Elisabeth, Höckel, Michael, Hoang, Lynn, Singh, Naveena, Horn, Lars-Christian

“…Vulvar squamous cell carcinoma (VSCC) can be stratified into three molecular subtypes based on the immunoexpression of p16 and p53: HPV-independent…”
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Changes in Tissue Fluidity Predict Tumor Aggressiveness In Vivo by Sauer, Frank, Grosser, Steffen, Shahryari, Mehrgan, Hayn, Alexander, Guo, Jing, Braun, Jürgen, Briest, Susanne, Wolf, Benjamin, Aktas, Bahriye, Horn, Lars-Christian, Sack, Ingolf, Käs, Josef A

“…Cancer progression is caused by genetic changes and associated with various alterations in cell properties, which also affect a tumor's mechanical state. While…”
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Association between developmental steps in the organogenesis of the uterine cervix and locoregional progression of cervical cancer: a prospective clinicopathological analysis by Höckel, Michael, Prof, Hentschel, Bettina, MA, Horn, Lars-Christian, MD

“…Summary Background Our previous work provided evidence that early cervical cancer is locally confined to the Müllerian compartment that develops in women from…”
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Invasive stratified mucin-producing carcinoma (i-SMILE) of the uterine cervix: report of a case series and review of the literature indicating poor prognostic subtype of cervical adenocarcinoma by Horn, Lars-Christian, Handzel, Romy, Borte, Gudrun, Siebolts, Udo, Haak, Anja, Brambs, Christine E.

“…Purpose Invasive stratified mucin-producing carcinoma (i-SMILE) represents a recently recognized subtype of cervical adenocarcinoma (AC) developing in a…”
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Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade) by Singh, Naveena, Hirschowitz, Lynn, Zaino, Richard, Alvarado-Cabrero, Isabel, Duggan, Maire A, Ali-Fehmi, Rouba, Euscher, Elizabeth, Hecht, Jonathan L, Horn, Lars-Christian, Ioffe, Olga, Matias-Guiu, Xavier, McCluggage, W Glenn, Mikami, Yoshiki, Ordi, Jaume, Parkash, Vinita, Quddus, M Ruhul, Quick, Charles M, Staebler, Annette, Zaloudek, Charles, Nucci, Marisa, Malpica, Anais, Oliva, Esther

“…Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase…”
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The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis by Lia, Massimiliano, Horn, Lars-Christian, Sodeikat, Paulina, Höckel, Michael, Aktas, Bahriye, Wolf, Benjamin

“…Cervical carcinoma is a major cause of morbidity and mortality among women worldwide. Histological subtype, lymphovascular space invasion and tumor grade could…”
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Heterogeneity between Core Needle Biopsy and Synchronous Axillary Lymph Node Metastases in Early Breast Cancer Patients-A Comparison of HER2, Estrogen and Progesterone Receptor Expression Profiles during Primary Treatment Regime by Weydandt, Laura, Nel, Ivonne, Kreklau, Anne, Horn, Lars-Christian, Aktas, Bahriye

“…In breast cancer therapeutic decisions are based on the expression of estrogen (ER), progesterone (PR), the human epidermal growth factor 2 (HER2) receptors…”
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Desmoplasia in cervical cancer is associated with a more aggressive tumor phenotype by Wolf, Benjamin, Weydandt, Laura, Dornhöfer, Nadja, Hiller, Grit Gesine Ruth, Höhn, Anne Kathrin, Nel, Ivonne, Jain, Rakesh K., Horn, Lars-Christian, Aktas, Bahriye

“…In cancer of the uterine cervix, the role of desmoplasia, i.e., peritumoral stromal remodeling characterized by fibroblast activation and increased…”
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Changes in the tumour microenvironment mark the transition from serous borderline tumour to low‐grade serous carcinoma by Vallejos, Rodrigo, Zhantuyakova, Almira, Negri, Gian Luca, Martin, Spencer D, Spencer, Sandra E, Thornton, Shelby, Leung, Samuel, Lynch, Branden, Qin, Yimei, Chow, Christine, Liang, Brooke, Zdravko, Sabrina, Douglas, J Maxwell, Milne, Katy, Mateyko, Bridget, Nelson, Brad H, Howitt, Brooke E, Kommoss, Felix KF, Horn, Lars‐Christian, Hoang, Lien, Singh, Naveena, Morin, Gregg B, Huntsman, David G, Cochrane, Dawn

“…Low‐grade serous ovarian carcinoma (LGSC) is a rare and lethal subtype of ovarian cancer. LGSC is pathologically, biologically, and clinically distinct from…”
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Epithelial–mesenchymal transition (EMT) in vulvar cancer with and without inguinal lymph node involvement by Brambs, Christine E., Horn, Lars-Christian, Mende, Meinhard, Höckel, Michael, Eckey, Christine, Hiller, Gesine Grit Ruth, Höhn, Anne Kathrin

“…Purpose Epithelial-mesenchymal transition (EMT) is associated with increased metastatic spread and poor prognosis. Data on vulvar carcinoma are limited…”
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The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat by Kurz, Susanne, Thieme, René, Amberg, Ronny, Groth, Marco, Jahnke, Heinz-Georg, Pieroh, Philipp, Horn, Lars-Christian, Kolb, Marlen, Huse, Klaus, Platzer, Matthias, Volke, Daniela, Dehghani, Faramarz, Buzdin, Anton, Engel, Kathrin, Robitzki, Andrea, Hoffmann, Ralf, Gockel, Ines, Birkenmeier, Gerd

“…Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice…”
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Histological and molecular characterization of TFEB-rearranged renal cell carcinomas by Wyvekens, Nicolas, Rechsteiner, Markus, Fritz, Christine, Wagner, Ulrich, Tchinda, Joëlle, Wenzel, Carina, Kuithan, Friederike, Horn, Lars-Christian, Moch, Holger

“…The 2016 WHO Classification of Tumors of the Urinary System recognizes microphthalmia transcription factor (MiT) family translocation carcinomas as a separate…”
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The Importance of Clinical Examination under General Anesthesia: Improving Parametrial Assessment in Cervical Cancer Patients by Sodeikat, Paulina, Lia, Massimiliano, Martin, Mireille, Horn, Lars-Christian, Höckel, Michael, Aktas, Bahriye, Wolf, Benjamin

“…Background: Parametrial tumor involvement is an important prognostic factor in cervical cancer and is used to guide management. Here, we investigate the…”
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Prognostic relevance of low-grade versus high-grade FIGO IB1 squamous cell uterine cervical carcinomas by Horn, Lars-Christian, Höhn, Anne Katrin, Hentschel, Bettina, Fischer, Uta, Bilek, Karl, Brambs, Christine E.

“…Purpose Tumor grade is one of the more controversial factors with limited prognostic information in squamous cell carcinomas (SCC) of the uterine cervix…”
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Roadmap to Local Tumour Growth: Insights from Cervical Cancer by Kubitschke, Hans, Wolf, Benjamin, Morawetz, Erik, Horn, Lars-Christian, Aktas, Bahriye, Behn, Ulrich, Höckel, Michael, Käs, Josef

“…Wide tumour excision is currently the standard approach to surgical treatment of solid cancers including carcinomas of the lower genital tract. This strategy…”
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High-intensity focused ultrasound (HIFU) hemiablation of the prostate: Late follow-up MRI findings in non-recurrent patients by Schaudinn, Alexander, Michaelis, Jakob, Franz, Toni, Ho-Thi, Phuc, Horn, Lars-Christian, Blana, Andreas, Hadaschik, Boris, Stumpp, Patrick, Stolzenburg, Jens-Uwe, Schlemmer, Heinz–Peter, Denecke, Timm, Busse, Harald, Ganzer, Roman, Linder, Nicolas

“…•Report of late MRI findings after prostate HIFU hemiablation in non-recurrent patients.•Common were shrinkage, residual prostate tissue, fluid-filled cavities…”
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