Search Results - "Horn, Kevin P"

Functional regeneration of respiratory pathways after spinal cord injury by Alilain, Warren J., Horn, Kevin P., Hu, Hongmei, Dick, Thomas E., Silver, Jerry

“…Spinal cord injuries often occur at the cervical level above the phrenic motor pools, which innervate the diaphragm. The effects of impaired breathing are a…”
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Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions by Horn, Kevin P, Busch, Sarah A, Hawthorne, Alicia L, van Rooijen, Nico, Silver, Jerry

“…Injured axons of the adult CNS undergo lengthy retraction from the initial site of axotomy after spinal cord injury. Macrophage infiltration correlates…”
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Overcoming Macrophage-Mediated Axonal Dieback Following CNS Injury by Busch, Sarah A, Horn, Kevin P, Silver, Daniel J, Silver, Jerry

“…Trauma to the adult CNS initiates multiple processes including primary and secondary axotomy, inflammation, and glial scar formation that have devastating…”
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Adult NG2+ Cells Are Permissive to Neurite Outgrowth and Stabilize Sensory Axons during Macrophage-Induced Axonal Dieback after Spinal Cord Injury by Busch, Sarah A, Horn, Kevin P, Cuascut, Fernando X, Hawthorne, Alicia L, Bai, Lianhua, Miller, Robert H, Silver, Jerry

“…We previously demonstrated that activated ED1+ macrophages induce extensive axonal dieback of dystrophic sensory axons in vivo and in vitro. Interestingly,…”
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Multipotent adult progenitor cells prevent macrophage-mediated axonal dieback and promote regrowth after spinal cord injury by Busch, Sarah A, Hamilton, Jason A, Horn, Kevin P, Cuascut, Fernando X, Cutrone, Rochelle, Lehman, Nicholas, Deans, Robert J, Ting, Anthony E, Mays, Robert W, Silver, Jerry

“…Macrophage-mediated axonal dieback presents an additional challenge to regenerating axons after spinal cord injury. Adult adherent stem cells are known to have…”
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Light-Induced Rescue of Breathing after Spinal Cord Injury by Alilain, Warren J, Li, Xiang, Horn, Kevin P, Dhingra, Rishi, Dick, Thomas E, Herlitze, Stefan, Silver, Jerry

“…Paralysis is a major consequence of spinal cord injury (SCI). After cervical SCI, respiratory deficits can result through interruption of descending…”
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A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI by Iannotti, Christopher A., Clark, Megan, Horn, Kevin P., van Rooijen, Nico, Silver, Jerry, Steinmetz, Michael P.

“…The present study assessed the ability of a combined immunomodulatory treatment using (1) selective depletion of peripheral macrophages with…”
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Assessment of Cardiac, Vascular, and Pulmonary Pathobiology In Vivo During Acute COVID-19 by Alam, Shirjel R, Vinayak, Sudhir, Shah, Adeel, Doolub, Gemina, Kimeu, Redemptar, Horn, Kevin P, Bowen, Stephen R, Jeilan, Mohamed, Lee, Kuan Ken, Gachoka, Sylvia, Riunga, Felix, Adam, Rodney D, Vesselle, Hubert, Joshi, Nikhil, Obino, Mariah, Makhdomi, Khalid, Ombati, Kevin, Nganga, Edward, Gitau, Samuel, Chung, Michael H, Shah, Anoop S V

“…Background Acute COVID-19-related myocardial, pulmonary, and vascular pathology and how these relate to each other remain unclear. To our knowledge, no studies…”
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FDG and FLT-PET for Early measurement of response to 37.5 mg daily sunitinib therapy in metastatic renal cell carcinoma by Horn, Kevin P, Yap, Jeffrey T, Agarwal, Neeraj, Morton, Kathryn A, Kadrmas, Dan J, Beardmore, Britney, Butterfield, Regan I, Boucher, Kenneth, Hoffman, John M

“…Metastatic renal cell carcinoma has a poor prognosis and an intrinsic resistance to standard treatment. Sunitinib is an oral receptor tyrosine kinase inhibitor…”
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Amyloid Positivity Using [18F]Flutemetamol-PET and Cognitive Deficits in Nondemented Community-Dwelling Older Adults by Hammers, Dustin B., Atkinson, Taylor J., Dalley, Bonnie C. A., Suhrie, Kayla R., Horn, Kevin P., Rasmussen, Kelli M., Beardmore, Britney E., Burrell, Lance D., Duff, Kevin, Hoffman, John M.

“…Little research exists examining the relationship between beta-amyloid neuritic plaque density via [18F]flutemetamol binding and cognition; consequently, the…”
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Relationship between 18F-Flutemetamol uptake and RBANS performance in non-demented community-dwelling older adults by Hammers, Dustin B., Atkinson, Taylor J., Dalley, Bonnie C. A., Suhrie, Kayla R., Beardmore, Britney E., Burrell, Lance D., Horn, Kevin P., Rasmussen, Kelli M., Foster, Norman L., Duff, Kevin, Hoffman, John M.

“…Objective: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) has been used extensively for clinical care and in research for…”
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PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration by Shen, Yingjie, Tenney, Alan P., Busch, Sarah A., Horn, Kevin P., Cuascut, Fernando X., Liu, Kai, He, Zhigang, Silver, Jerry, Flanagan, John G.

“…Chondroitin sulfate proteoglycans (CSPGs) present a barrier to axon regeneration. However, no specific receptor for the inhibitory effect of CSPGs has been…”
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Clinical Pilot of a Deep Learning Elastic Registration Algorithm to Improve Misregistration Artifact and Image Quality on Routine Oncologic PET/CT by Chamberlin, Jordan H., Schaefferkoetter, Joshua, Hamill, James, Kabakus, Ismail M., Horn, Kevin P., O’Doherty, Jim, Elojeimy, Saeed

“…Misregistration artifacts between the PET and attenuation correction CT (CTAC) exams can degrade image quality and cause diagnostic errors. Deep learning…”
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Is Cancer Protective for Subsequent Alzheimer's Disease Risk? Evidence From the Utah Population Database by Hanson, Heidi A, Horn, Kevin P, Rasmussen, Kelli M, Hoffman, John M, Smith, Ken R

“…Several studies have suggested that cancer is associated with a reduced risk of the development of Alzheimer's disease (AD). This study seeks to improve our…”
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Long-term Changes in 18F-Flutemetamol Uptake in Nondemented Older Adults by Duff, Kevin, Horn, Kevin P, Hoffman, John M

“…PURPOSE:Longitudinal studies into the variability of F-Flutemetamol uptake are lacking. METHODS/PATIENTS:Therefore, the current study examined change in…”
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Immature astrocytes promote CNS axonal regeneration when combined with chondroitinase ABC by Filous, Angela R., Miller, Jared H., Coulson‐Thomas, Yvette M., Horn, Kevin P., Alilain, Warren J., Silver, Jerry

“…Regeneration of injured adult CNS axons is inhibited by formation of a glial scar. Immature astrocytes are able to support robust neurite outgrowth and reduce…”
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Reliability of Quantitative 18F-FDG PET/CT Imaging Biomarkers for Classifying Early Response to Chemoradiotherapy in Patients With Locally Advanced Non–Small Cell Lung Cancer by Horn, Kevin P., Thomas, Hannah M.T., Vesselle, Hubert J., Kinahan, Paul E., Miyaoka, Robert S., Rengan, Ramesh, Zeng, Jing, Bowen, Stephen R.

“…We evaluated the reliability of 18F-FDG PET imaging biomarkers to classify early response status across observers, scanners, and reconstruction algorithms in…”
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Lipopolysaccharide endotoxemia induces amyloid-β and p-tau formation in the rat brain by Wang, Li-Ming, Wu, Qi, Kirk, Ryan A, Horn, Kevin P, Ebada Salem, Ahmed H, Hoffman, John M, Yap, Jeffrey T, Sonnen, Joshua A, Towner, Rheal A, Bozza, Fernando A, Rodrigues, Rosana S, Morton, Kathryn A

“…Amyloid beta (Aβ) plaques are not specific to Alzheimer's disease and occur with aging and neurodegenerative disorders. Soluble brain Aβ may be neuroprotective…”
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Correlation of Glioma Proliferation and Hypoxia by Luciferase, Magnetic Resonance, and Positron Emission Tomography Imaging by Karsy, Michael, Gillespie, David L, Horn, Kevin P, Burrell, Lance D, Yap, Jeffery T, Jensen, Randy L

“…Gliomas are the most common type of primary, malignant brain tumor and significantly impact patients, who have a median survival of ~1 year depending on…”
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Chronic Enhancement of the Intrinsic Growth Capacity of Sensory Neurons Combined with the Degradation of Inhibitory Proteoglycans Allows Functional Regeneration of Sensory Axons through the Dorsal Root Entry Zone in the Mammalian Spinal Cord by Steinmetz, Michael P, Horn, Kevin P, Tom, Veronica J, Miller, Jared H, Busch, Sarah A, Nair, Dileep, Silver, Daniel J, Silver, Jerry

“…Peripherally conditioned sensory neurons have an increased capacity to regenerate their central processes. However, even conditioned axons struggle in the…”
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