Search Results - "Horn, Evi"

Atypical cellular responses mediated by intracellular constitutive active TrkB (NTRK2) kinase domains and a solely intracellular NTRK2-fusion oncogene by Gupta, Rohini, Dittmeier, Melanie, Wohlleben, Gisela, Nickl, Vera, Bischler, Thorsten, Luzak, Vanessa, Wegat, Vanessa, Doll, Dennis, Sodmann, Annemarie, Bady, Elena, Langlhofer, Georg, Wachter, Britta, Havlicek, Steven, Gupta, Jahnve, Horn, Evi, Lüningschrör, Patrick, Villmann, Carmen, Polat, Bülent, Wischhusen, Jörg, Monoranu, Camelia M., Kuper, Jochen, Blum, Robert

“…Trk ( NTRK ) receptor and NTRK gene fusions are oncogenic drivers of a wide variety of tumors. Although Trk receptors are typically activated at the cell…”
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Cognate Nonlytic Interactions between CD8 + T Cells and Breast Cancer Cells Induce Cancer Stem Cell-like Properties by Stein, Roland G, Ebert, Stefan, Schlahsa, Laura, Scholz, Claus J, Braun, Matthias, Hauck, Petra, Horn, Evi, Monoranu, Camelia-Maria, Thiemann, Vincent J, Wustrow, Michael P, Häusler, Sebastian F, Montalbán Del Barrio, Itsaso, Stüber, Tanja N, Wölfl, Matthias, Dietl, Johannes, Rosenwald, Andreas, Diessner, Joachim E, Wöckel, Achim, Wischhusen, Jörg

“…Targeting of tumor immune escape mechanisms holds enormous therapeutic potential. Still, most patients progress under immune checkpoint blockade and some even…”
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Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity by Häusler, Sebastian F. M., Montalbán del Barrio, Itsaso, Strohschein, Jenny, Anoop Chandran, P., Engel, Jörg B., Hönig, Arnd, Ossadnik, Monika, Horn, Evi, Fischer, Birgitt, Krockenberger, Mathias, Heuer, Stefan, Seida, Ahmed Adel, Junker, Markus, Kneitz, Hermann, Kloor, Doris, Klotz, Karl-Norbert, Dietl, Johannes, Wischhusen, Jörg

“…The ectonucleotidases CD39 and CD73 degrade immune stimulatory ATP to adenosine that inhibits T and NK cell responses via the A 2A adenosine receptor…”
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The TGF‐β‐inducible miR‐23a cluster attenuates IFN‐γ levels and antigen‐specific cytotoxicity in human CD8+ T cells by Chandran, P. Anoop, Keller, Andreas, Weinmann, Lasse, Adel Seida, Ahmed, Braun, Matthias, Andreev, Katerina, Fischer, Birgitt, Horn, Evi, Schwinn, Stefanie, Junker, Markus, Houben, Roland, Dombrowski, Yvonne, Dietl, Johannes, Finotto, Susetta, Wölfl, Matthias, Meister, Gunter, Wischhusen, Jörg

“…The TGF‐β‐inducible miR‐23a cluster attenuates IFN‐γ production and antigen specific cytotoxicity, and fine‐tunes CD8+ T cell effector functions. Cytokine…”
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Macrophage Migration-inhibitory Factor Levels in Serum of Patients with Ovarian Cancer Correlates with Poor Prognosis by KROCKENBERGER, Mathias, KRANKE, Peter, HÄUSLER, Sebastian, ENGEL, Jörg Bernhard, HORN, Evi, NÜRNBERGER, Katharina, WISCHHUSEN, Jorg, DIETL, Johannes, HÖNIG, Arnd

“…Ovarian cancer is generally thought of as a cancer with poor prognosis. However, prognostic appraisal of the disease is based on tumor stages, surgical…”
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Induction of programmed cell death by inhibition of AKT with the alkylphosphocholine perifosine in in vitro models of platinum sensitive and resistant ovarian cancers by Engel, Jörg B., Schönhals, Tanja, Häusler, Sebastian, Krockenberger, Mathias, Schmidt, Melanie, Horn, Evi, Köster, Frank, Dietl, Johannes, Wischhusen, Jörg, Honig, Arnd

“…Purpose We analyzed the anti-tumor effect and the mechanism of action of perifosine, an orally active alkylphospholipid AKT inhibitor using in vitro models of…”
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A cell-based luciferase-dependent assay for the quantitative determination of free extracellular adenosine with paracrine signaling activity by Häusler, Sebastian F.M., Ossadnik, Monika, Horn, Evi, Heuer, Stefan, Dietl, Johannes, Wischhusen, Jörg

“…Extracellular adenosine exerts powerful paracrine effects on immune cells. Thus, adenosine signaling has to be strictly regulated. This is achieved by its…”
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