Search Results - "Hormone and metabolic research"

A Systematic Review and Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors by de Filette, Jeroen, Andreescu, Corina Emilia, Cools, Filip, Bravenboer, Bert, Velkeniers, Brigitte

“…Monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4), programed cell death 1 (PD-1), or its ligand (PD-L1) have become the mainstay for…”
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The ACE-2 in COVID-19: Foe or Friend? by Dalan, Rinkoo, Bornstein, Stefan R, El-Armouche, Ali, Rodionov, Roman N, Markov, Alexander, Wielockx, Ben, Beuschlein, Felix, Boehm, Bernhard O

“…COVID-19 is a rapidly spreading outbreak globally. Emerging evidence demonstrates that older individuals and people with underlying metabolic conditions of…”
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FGF21: A Novel Regulator of Glucose and Lipid Metabolism and Whole-Body Energy Balance by Szczepańska, Ewa, Gietka-Czernel, Małgorzata

“…Fibroblast growth factor (FGF) 21 is a recently recognized metabolic regulator that evokes interest due to its beneficial action of maintaining whole-body…”
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Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial by Roshanravan, Neda, Mahdavi, Reza, Alizadeh, Effat, Jafarabadi, Mohammad Asghari, Hedayati, Mehdi, Ghavami, Abed, Alipour, Shahriar, Alamdari, Naimeh Mesri, Barati, Meisam, Ostadrahimi, Alireza

“…Studies on humans with diabetes mellitus showed that the crosstalk between the intestinal microbiota and the host has a key role in controlling the disease…”
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Empagliflozin, an Inhibitor of Sodium-Glucose Cotransporter 2 Exerts Anti-Inflammatory and Antifibrotic Effects on Experimental Diabetic Nephropathy Partly by Suppressing AGEs-Receptor Axis by Ojima, A, Matsui, T, Nishino, Y, Nakamura, N, Yamagishi, S

“…Advanced glycation end products (AGEs) and receptor RAGE play a role in diabetic nephropathy. We have previously shown that increased glucose uptake into…”
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The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding by Ajjan, R A, Weetman, A P

“…Hashimoto's thyroiditis (HT) is part of a spectrum of thyroid autoimmune conditions and this review provides an update on the latest developments in the field…”
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Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model by Kakino, Satomi, Ohki, Tsuyoshi, Nakayama, Hitomi, Yuan, Xiahong, Otabe, Shuichi, Hashinaga, Toshihiko, Wada, Nobuhiko, Kurita, Yayoi, Tanaka, Kayo, Hara, Kento, Soejima, Eri, Tajiri, Yuji, Yamada, Kentaro

“…Previously, we have shown that the adipocyte-specific nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c) transgenic mice spontaneously…”
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Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Effect of SGLT2 Inhibitor on Blood Leptin and Adiponectin Level in Patients with Type 2 Diabetes by Wu, Peili, Wen, Weiheng, Li, Jitong, Xu, Jie, Zhao, Min, Chen, Hong, Sun, Jia

“…Sodium glucose cotransporter 2 (SGLT2) inhibitors are a new kind of hypoglycemic drugs that improve glucose homeostasis by inhibiting renal glucose…”
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Current Insights into the Pathogenesis of Graves' Ophthalmopathy by Bahn, R S

“…Environmental, genetic, and immune factors are at play in the development of the variable clinical manifestations of Graves' ophthalmopathy (GO). Among the…”
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Diagnosis, Pathophysiology and Management of Hypercalcemia in Malignancy: A Review of the Literature by Asonitis, Nikolaos, Angelousi, Anna, Zafeiris, Christos, Lambrou, George I, Dontas, Ismene, Kassi, Eva

“…Hypercalcemia of malignancy is the most common life-threatening metabolic disorder in patients with advanced stage cancers and is a sign of poor prognosis. It…”
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Bone Marrow Stromal Stem Cells in Tissue Engineering and Regenerative Medicine by Polymeri, A, Giannobile, W V, Kaigler, D

“…Bone marrow stromal stem cells (BMSCs) are adult multipotent cells, which have the potential to differentiate into cell types of mesodermal origin, namely…”
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Can Supplementation with Vitamin D Modify Thyroid Autoantibodies (Anti-TPO Ab, Anti-Tg Ab) and Thyroid Profile (T3, T4, TSH) in Hashimoto's Thyroiditis? A Double Blind, Randomized Clinical Trial by Chahardoli, Reza, Saboor-Yaraghi, Ali-Akbar, Amouzegar, Atieh, Khalili, Davood, Vakili, Azita Zadeh, Azizi, Fereidoun

“…Hashimoto's thyroiditis (HT) is the most prevalent autoimmune disorder characterized by the destruction of thyroid cells caused by leukocytes and…”
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Obesity is Associated with Poor Covid-19 Outcomes: A Systematic Review and Meta-Analysis by Hoong, Caroline Wei Shan, Hussain, Ikram, Aravamudan, Veeraraghavan Meyyur, Phyu, Ei Ei, Lin, Jaime Hui Xian, Koh, Huilin

“…Our aim was to assess the association between obesity and the risk of unfavourable outcomes (composite of severe disease and mortality) in inpatients with…”
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Formononetin inhibits migration and invasion of MDA-MB-231 and 4T1 breast cancer cells by suppressing MMP-2 and MMP-9 through PI3K/AKT signaling pathways by Zhou, R, Xu, L, Ye, M, Liao, M, Du, H, Chen, H

“…Formononetin is a naturally existing isoflavone, which can be found in the roots of Astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and…”
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Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation by Ishibashi, Y, Matsui, T, Yamagishi, S

“…Ninety percent of glucose filtered by the glomerulus is reabsorbed by a sodium-glucose cotransporter 2 (SGLT2), which is mainly expressed on S1 and S2 segment…”
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The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Akbari, Maryam, Ostadmohammadi, Vahidreza, Lankarani, Kamran B, Tabrizi, Reza, Kolahdooz, Fariba, Heydari, Seyed Taghi, Kavari, Seyed Habibollah, Mirhosseini, Naghmeh, Mafi, Alireza, Dastorani, Majid, Asemi, Zatollah

“…The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on…”
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Prevalence of primary aldosteronism in patient's cohorts and in population-based studies--a review of the current literature by Hannemann, A, Wallaschofski, H

“…There is an ongoing controversy on the prevalence of primary aldosteronism (PA). We aimed to update a meta-analysis published in 2008, that compiled studies…”
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Thyroid Function in Human Obesity: Underlying Mechanisms by Fontenelle, L C, Feitosa, M M, Severo, J S, Freitas, T E C, Morais, J B S, Torres-Leal, F L, Henriques, G S, do Nascimento Marreiro, D

“…Obesity is associated with several metabolic and endocrine disorders; and changes in plasma concentrations, secretion patterns, and clearance of various…”
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Differential Expression of Glucocorticoid Receptor Noncoding RNA Repressor Gas5 in Autoimmune and Inflammatory Diseases by Mayama, T, Marr, A K, Kino, T

“…Glucocorticoids have strong regulatory actions on the immune system and act as potent therapeutic compounds for autoimmune and inflammatory diseases. We…”
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Effects of Quercetin on Adiponectin-Mediated Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized Placebo-Controlled Double-Blind Clinical Trial by Rezvan, N, Moini, A, Janani, L, Mohammad, K, Saedisomeolia, A, Nourbakhsh, M, Gorgani-Firuzjaee, S, Mazaherioun, M, Hosseinzadeh-Attar, M J

“…Polycystic ovary syndrome (PCOS) is a heterogeneous, multi-causal, and genetically complex disorder, which is related to the failure in endocrine glands…”
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