Search Results - "Horley, Neill J"

Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines by Horley, Neill J., Beresford, Kenneth J.M., Chawla, Tarun, McCann, Glen J.P., Ruparelia, Ketan C., Gatchie, Linda, Sonawane, Vinay R., Williams, Ibidapo S., Tan, Hoon L., Joshi, Prashant, Bharate, Sonali S., Kumar, Vikas, Bharate, Sandip B., Chaudhuri, Bhabatosh

“…The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k…”
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Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain by Al‐Anizy, Mohammed, Horley, Neill J., Kuo, C.‐W. S., Gillett, Lorna C., Laughton, Charles A., Kendall, David, Barrett, David A., Parker, Terry, Bell, David R.

“…A novel cytochrome P450, CYP4x1, was identified in EST databases on the basis of similarity to a conserved region in the C‐helix of the CYP4A family. The human…”
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(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent by Horley, Neill J., Beresford, Kenneth J.M., Kaduskar, Supriya, Joshi, Prashant, McCann, Glen J.P., Ruparelia, Ketan C., Williams, Ibidapo S., Gatchie, Linda, Sonawane, Vinay R., Bharate, Sandip B., Chaudhuri, Bhabatosh

“…[Display omitted] The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported…”
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Molecular analysis of peroxisome proliferation in the hamster by Choudhury, Agharul I, Sims, Helen M, Horley, Neill J, Roberts, Ruth A, Tomlinson, Simon R, Salter, Andrew M, Bruce, Mary, Shaw, P.Nicholas, Kendall, David, Barrett, David A, Bell, David R

“…Three novel P450 members of the cytochrome P450 4A family were cloned as partial cDNAs from hamster liver, characterised as novel members of the CYP4A…”
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The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate by PLANT, N. J, HORLEY, N. J, DICKINS, M, HASMALL, S, ELCOMBE, C. R, BELL, D. R

“…The coordinate regulation of DNA synthesis and suppression of apoptosis was investigated in a rat hepatocyte cell culture system which supports high level…”
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Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARα is functional and mediates peroxisome proliferator-induced hypolipidaemia by BELL, Alex R., SAVORY, Richard, HORLEY, Neill J., CHOUDHURY, Agharul I., DICKINS, Maurice, GRAY, Tim J. B., SALTER, Andrew M., BELL, David R.

“…The guinea pig does not undergo peroxisome proliferation in response to peroxisome proliferators, in contrast with other rodents. To understand the molecular…”
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The peroxisome proliferators are hepatocyte mitogens in chemically-defined media : glucocorticoid-induced PPARα is linked to peroxisome proliferator mitogenesis by PLANT, N. J, HORLEY, N. J, SAVORY, R. L, ELCOMBE, C. R, GRAY, T. J. B, BELL, D. R

“…Peroxisome proliferator-induced mitogenesis is believed to play a role in hepatocarcinogenesis, but it has not been possible to demonstrate high level…”
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The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: Glucocorticoid-induced (PPAR alpha) is linked to peroxisome proliferator mitogenesis by Plant, Nicholas J, Horley, Neill J, Savory, Richard L, Elcombe, Clifford R

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Peroxisome proliferators induce high levels of DNA synthesis in primary cultures of rat hepatocytes by Bell, D R, Plant, N J, Horley, N J, Elcombe, C R

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