Search Results - "Horkko, S"

Salivary IgA to MAA-LDL and Oral Pathogens Are Linked to Coronary Disease by Akhi, R., Wang, C., Nissinen, A.E., Kankaanpää, J., Bloigu, R., Paju, S., Mäntylä, P., Buhlin, K., Sinisalo, J., Pussinen, P.J., Hörkkö, S.

“…A large body of literature has established the link between periodontal disease and cardiovascular disease. Oxidized low-density lipoproteins (OxLDLs) have a…”
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Carotid artery calcification in panoramic radiographs associates with oral infections and mortality by Paju, S., Pietiäinen, M., Liljestrand, J. M., Lahdentausta, L., Salminen, A., Kopra, E., Mäntylä, P., Buhlin, K., Hörkkö, S., Sinisalo, J., Pussinen, P. J.

“…Aim To study the prevalence of carotid artery calcification (CAC) in relation to apical and marginal periodontitis, subgingival dysbiotic bacterial species and…”
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Carotid artery calcification in panoramic radiographs associates with oral infections and mortality by Paju, S., Pietiäinen, M., Liljestrand, J. M., Lahdentausta, L., Salminen, A., Kopra, E., Mäntylä, P., Buhlin, K., Hörkkö, S., Sinisalo, J., Pussinen, P. J.

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Long-chain polyphosphates inhibit type I interferon signaling and augment LPS-induced cytokine secretion in human leukocytes by Pirttiniemi, Anniina, Adeshara, Krishna, Happonen, Natalie, Einarsdottir, Elisabet, Katayama, Shintaro, Salmenkari, Hanne, Hörkkö, Sohvi, Kere, Juha, Groop, Per-Henrik, Lehto, Markku

“…Inorganic polyphosphates are evolutionarily conserved bioactive phosphate polymers found as various chain lengths in all living organisms. In mammals,…”
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Immunization with gingipain A hemagglutinin domain of Porphyromonas gingivalis induces IgM antibodies binding to malondialdehyde-acetaldehyde modified low-density lipoprotein by Kyrklund, Mikael, Kummu, Outi, Kankaanpää, Jari, Akhi, Ramin, Nissinen, Antti, Turunen, S Pauliina, Pussinen, Pirkko, Wang, Chunguang, Hörkkö, Sohvi

“…Treatment of periodontitis has beneficial effects on systemic inflammation markers that relate to progression of atherosclerosis. We aimed to investigate…”
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Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity by Shaw, P X, Hörkkö, S, Chang, M K, Curtiss, L K, Palinski, W, Silverman, G J, Witztum, J L

“…The immune response to oxidized LDL (OxLDL) may play an important role in atherogenesis. Working with apoE-deficient mice, we isolated a panel of…”
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Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice. Demonstration of epitopes of oxidized low density lipoprotein in human plasma by Palinski, W, Hörkkö, S, Miller, E, Steinbrecher, U P, Powell, H C, Curtiss, L K, Witztum, J L

“…Many reactive products may be formed when LDL undergoes lipid peroxidation, which in turn can react with lipids, apoproteins, and proteins, generating…”
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Immunization of LDL Receptor-Deficient Mice With Homologous Malondialdehyde-Modified and Native LDL Reduces Progression of Atherosclerosis by Mechanisms Other Than Induction of High Titers of Antibodies to Oxidative Neoepitopes by Freigang, Stefan, Horkko, Sohvi, Miller, Elizabeth, Witztum, Joseph L, Palinski, Wulf

“…We and others previously showed that immunization of rabbits with different forms of oxidized low density lipoprotein (LDL) significantly reduced…”
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Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins by Hörkkö, S, Bird, D A, Miller, E, Itabe, H, Leitinger, N, Subbanagounder, G, Berliner, J A, Friedman, P, Dennis, E A, Curtiss, L K, Palinski, W, Witztum, J L

“…We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO-…”
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Monoclonal Antibodies against Oxidized Low-Density Lipoprotein Bind to Apoptotic Cells and Inhibit Their Phagocytosis by Elicited Macrophages: Evidence That Oxidation-Specific Epitopes Mediate Macrophage Recognition by Chang, Mi-Kyung, Bergmark, Claes, Laurila, Aino, Hörkkö, Sohvi, Han, Ki-Hoon, Friedman, Peter, Dennis, Edward A., Witztum, Joseph L.

“…Apoptosis is recognized as important for normal cellular homeostasis in multicellular organisms. Although there have been great advances in our knowledge of…”
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Human-Derived Anti-Oxidized LDL Autoantibody Blocks Uptake of Oxidized LDL by Macrophages and Localizes to Atherosclerotic Lesions In Vivo by Shaw, Peter X, Hörkkö, Sohvi, Tsimikas, Sotirios, Chang, Mi-Kyung, Palinski, Wulf, Silverman, Gregg J, Chen, Pojen P, Witztum, Joseph L

“…Autoantibodies to oxidation-specific epitopes of low density lipoprotein (LDL), such as malondialdehyde-modified LDL (MDA-LDL), occur in plasma and…”
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Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein by Hörkkö, S, Miller, E, Dudl, E, Reaven, P, Curtiss, L K, Zvaifler, N J, Terkeltaub, R, Pierangeli, S S, Branch, D W, Palinski, W, Witztum, J L

“…The optimal clinical management of patients with antiphospholipid antibody syndrome (APS) is uncertain because of a lack of an underlying hypothesis to explain…”
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Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo by Watson, A D, Leitinger, N, Navab, M, Faull, K F, Hörkkö, S, Witztum, J L, Palinski, W, Schwenke, D, Salomon, R G, Sha, W, Subbanagounder, G, Fogelman, A M, Berliner, J A

“…Entry of monocytes into the vessel wall is an important event in atherogenesis. Previous studies from our laboratory suggest that oxidized arachidonic…”
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The Binding of Oxidized Low Density Lipoprotein to Mouse CD36 Is Mediated in Part by Oxidized Phospholipids That Are Associated with Both the Lipid and Protein Moieties of the Lipoprotein by Boullier, Agnès, Gillotte, Kristin L., Hörkkö, Sohvi, Green, Simone R., Friedman, Peter, Dennis, Edward A., Witztum, Joseph L., Steinberg, Daniel, Quehenberger, Oswald

“…There is growing evidence that CD36 has an important physiological function in the uptake of oxidized low density lipoprotein (OxLDL) by macrophages. However,…”
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The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes by PÖYKKÖ, S. M, UKKOLA, O, KAUMA, H, KELLOKOSKI, E, HÖRKKÖ, S, KESÄNIEMI, Y. A

“…Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the…”
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Immunological responses to oxidized LDL by Hörkkö, Sohvi, Binder, Christoph J, Shaw, Peter X, Chang, Mi-Kyung, Silverman, Gregg, Palinski, Wulf, Witztum, Joseph L

“…Considerable evidence now points to an important role for the immune system in experimental models of atherosclerosis. We have reviewed the growing body of…”
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Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells by Bird, D.A, Gillotte, K.L, Horkko, S, Friedman, P, Dennis, E.A, Witztum, J.L, Steinberg, D

“…It has been shown previously that the binding of oxidized low-density lipoprotein (OxLDL) to resident mouse peritoneal macrophages can be inhibited (up to 70%)…”
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Intestinal alkaline phosphatase at the crossroad of intestinal health and disease – a putative role in type 1 diabetes by Lassenius, M. I., Fogarty, C. L., Blaut, M., Haimila, K., Riittinen, L., Paju, A., Kirveskari, J., Järvelä, J., Ahola, A. J., Gordin, D., Härma, M.‐A., Kumar, A., Hamarneh, S. R., Hodin, R. A., Sorsa, T., Tervahartiala, T., Hörkkö, S., Pussinen, P. J., Forsblom, C., Jauhiainen, M., Taskinen, M.‐R., Groop, P.‐H., Lehto, M.

“…Background Patients with type 1 diabetes have shown an increase in circulating cytokines, altered lipoprotein metabolism and signs of vascular dysfunction in…”
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Anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome recognize epitopes in both beta(2)-glycoprotein 1 and oxidized low-density lipoprotein by Hörkkö, S, Olee, T, Mo, L, Branch, D W, Woods, Jr, V L, Palinski, W, Chen, P P, Witztum, J L

“…We recently suggested that many anticardiolipin antibodies bind only to oxidized cardiolipin (OxCL) and/or to OxCL-beta(2)-glycoprotein 1 (beta(2)GP1) adducts…”
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Antibodies to malondialdehyde-acetaldehyde modified low-density lipoprotein in patients with newly diagnosed inflammatory joint disease by Kononoff, A, Hörkkö, S, Pussinen, P, Kautiainen, H, Elfving, P, Savolainen, E, Arstila, L, Niinisalo, H, Rutanen, J, Marjoniemi, O, Kaipiainen-Seppänen, O

“…:To assess antibodies to malondialdehyde-acetaldehyde-modified low-density lipoprotein (MAA-LDL) in patients with newly diagnosed inflammatory joint disease. :…”
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