Search Results - "Horiuchi, Kazumi"

AMPA Receptor‐Mediated Excitotoxicity in Human NT2‐N Neurons Results from Loss of Intracellular Ca2+ Homeostasis Following Marked Elevation of Intracellular Na+ by Itoh, Takayuki, Itoh, Aki, Horiuchi, Kazumi, Pleasure, David

“…: Human NT2‐N neurons express Ca2+‐permeable α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid glutamate receptors (AMPA‐GluRs) and become vulnerable to…”
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Effect of digitonin concentration on regeneration of cattle rhodopsin by Matsumoto, H, Horiuchi, K, Yoshizawa, T

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Mixed chimerism following in utero hematopoietic stem cell transplantation in murine models of hemoglobinopathy by Hayashi, Satoshi, Abdulmalik, Osheiza, Peranteau, William H, Ashizuka, Shuichi, Campagnoli, Cesare, Chen, Quigen, Horiuchi, Kazumi, Asakura, Toshio, Flake, Alan W

“…Mixed hematopoietic chimerism after bone marrow transplantation can provide effective treatment for β-thalassemia because of the selective advantage that…”
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Effects of Different β73 Amino Acids on Formation of 14-Stranded Fibers of Hb S versus Double-Stranded Crystals of Hb C-Harlem by Adachi, Kazuhiko, Ding, Min, Wehrli, Suzanne, Reddy, Konda S, Surrey, Saul, Horiuchi, Kazumi

“…Hb S (α2β2 6Glu→Val) forms polymers, while Hb C-Harlem (α2β2 6Glu→Val,73Asp→Asn) forms crystals upon oversaturation. Since the only difference between the two…”
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Effects of different beta73 amino acids on formation of 14-stranded fibers of Hb S versus double-stranded crystals of Hb C-Harlem by Adachi, Kazuhiko, Ding, Min, Wehrli, Suzanne, Reddy, Konda S, Surrey, Saul, Horiuchi, Kazumi

“…Hb S (alpha(2)beta(2)(6Glu-->Val)) forms polymers, while Hb C-Harlem (alpha(2)beta(2)(6Glu-->Val,73Asp-->Asn)) forms crystals upon oversaturation. Since the…”
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Flexibility and nucleation in sickle hemoglobin by Ivanova, M, Jasuja, R, Krasnosselskaia, L, Josephs, R, Wang, Z, Ding, M, Horiuchi, K, Adachi, K, Ferrone, F A

“…We have studied the self-assembly of Hemoglobin C-Harlem (HbC-Harlem), a double mutant of hemoglobin that possesses the beta6 Glu-->Val mutation of sickle…”
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Flexibility and nucleation in sickle hemoglobin 1 1Edited by M. F. Moody by Ivanova, Maria, Jasuja, Ravi, Krasnosselskaia, Lada, Josephs, Robert, Wang, Zhiping, Ding, Min, Horiuchi, Kazumi, Adachi, Kazuhiko, Ferrone, Frank A

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AMPA Receptor‐Mediated Excitotoxicity in Human NT2‐N Neurons Results from Loss of Intracellular Ca 2+ Homeostasis Following Marked Elevation of Intracellular Na by Itoh, Takayuki, Itoh, Aki, Horiuchi, Kazumi, Pleasure, David

“…Human NT2‐N neurons express Ca 2+ ‐permeable α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid glutamate receptors (AMPA‐GluRs) and become vulnerable to…”
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Combined use of nonmyelosuppressive nitrosourea analogues with hydroxyurea in the induction of F-cell production in a human erythroleukemic cell line by Iyamu, Efemwonkiekie W, Adunyah, Samuel E, Fasold, Hugo, Horiuchi, Kazumi, Baliga, Surendra, Ohene-Frempong, Kwaku, Turner, Ernest A, Asakura, Toshio

“…Objective. Although hydroxyurea (HU) has been used clinically to treat patients with sickle cell disease (SCD), not all patients benefit from HU treatment due…”
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Survival of F-Reticulocytes in Sickle Cell Disease by Horiuchi, K., Osterhout, M.L., Ohenefrempong, K.

“…Fetal hemoglobin, Hb F, is known to be an important factor for clinical course of sickle cell disease, as it suppresses polymerization of sickle hemoglobin. To…”
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Identification of F-reticulocytes by two-stage fluorescence image cytometry by Osterhout, ML, Ohene-Frempong, K, Horiuchi, K

“…Precise determination of reticulocytes (young red blood cells) containing fetal hemoglobin (Hb F), F-reticulocytes, is important for assessment of the efficacy…”
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Sickling in Vitro at Venous and Arterial Oxygen Tensions of Reticulocytes from Patients with Sickle Cell Disease by Onyike, A.E., Ohenefrempong, K., Horiuchi, K.

“…Sickling of reticulocytes and mature erythrocytes from patients with sickle cell disease was compared at venous and arterial oxygen tensions (PO 2 = 30 and 90…”
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Image analysis studies of the degree of irreversible deformation of sickle cells in relation to cell density and Hb F level by Horiuchi, K, Stephens, M J, Adachi, K, Asakura, T, Schwartz, E, Ohene-Frempong, K

“…We analyzed, quantitatively by image analysis, the degree of irreversible deformation of red cells (SS cells) from patients with homozygous sickle cell…”
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The Effect of Deoxygenation Rate on the Formation of Irreversibly Sickled Cells by Horiuchi, Kazumi, Ballas, Samir K., Asakura, Toshio

“…The effects of the deoxygenation rate on the formation of irreversibly sickled cells (ISCs) were investigated by using metabolically replete sickle cells (SS…”
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Binding of β‐Naphthyl Triphosphate to Human Adult Hemoglobin Accompanying Deoxygenation by HORIUCHI, Kazumi, ASAI, Hiroshi

“…Binding of a fluorescent allosteric effector, β‐naphthyl triphosphate (β‐NapP3), to human adult hemoglobin (HbA) at various levels of oxygen saturation were…”
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Some characteristics of beta-naphthyl oligophosphates as allosteric effectors of human hemoglobin by Horiuchi, K

“…1. Fluorescent organic phosphates. beta-naphthyl oligophosphates, were found to interact with human hemoglobin, and to lower the oxygen affinity. The magnitude…”
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A reaction cell for simultaneous measurements of fluorescence and absorption in a hemoglobin solution at various oxygen pressures by Horiuchi, K, Asai, H

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Hemolysis by aliphatic alcohols and saponin measured by the coil planet centrifugation method by Finegold, A A, Horiuchi, K, Kamiya, K, Asakura, T

“…Using the coil planet centrifugation method, the mechanism of hemolysis by alcohols and saponin was investigated. With this technique, erythrocytes are…”
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Abnormal membrane properties of the sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia: modes of action of halothane, caffeine, dantrolene, and two other drugs by Ohnishi, S T, Waring, A J, Fang, S R, Horiuchi, K, Flick, J L, Sadanaga, K K, Ohnishi, T

“…The role of sarcoplasmic reticulum (SR) in malignant hyperthermia (MH) was studied using the heavy microsomal fraction prepared from semitendinosus muscles of…”
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Binding of β-naphthyl triphosphate to human adult hemoglobin accompanying deoxygenation. Investigated by simultaneous measurements of fluorescence, absorbance and partial pressure of oxygen by HORIUCHI, K, ASAI, H

“…Binding of a fluorescent allosteric effector, beta-naphthyl triphosphate (beta-NapP3), to human adult hemoglobin (HbA) at various levels of oxygen saturation…”
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