Search Results - "Horisberger, J D"

Recent Insights into the Structure and Mechanism of the Sodium Pump by Horisberger, J.-D

“…J.-D. Horisberger Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland jean-daniel.horisberger{at}ipharm.unil.ch…”
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An epithelial serine protease activates the amiloride-sensitive sodium channel by Rossier, Bernard C, Vallet, Vronique, Chraibi, Ahmed, Gaeggeler, Hans-Peter, Horisberger, Jean-Daniel

“…Sodium balance, and ultimately blood pressure and extracellular fluid volume, is maintained by precise regulation of the activity of the epithelial sodium…”
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Rapid fluidic exchange microsystem for recording of fast ion channel kinetics in Xenopus oocytes by Dahan, E, Bize, V, Lehnert, T, Horisberger, J-D, Gijs, M A M

“…We present a new lab-on-a-chip system for electrophysiological measurements on Xenopus oocytes. Xenopus oocytes are widely used host cells in the field of…”
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Epithelial sodium channel related to proteins involved in neurodegeneration by Canessa, Cecilia M, Horisberger, Jean-Daniel, Rossier, Bernard C

“…The epithelial amiloride-sensitive sodium channel constitutes the rate limiting step for sodium reabsorbtion by the epithelial lining the distal part of the…”
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Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel α subunit in A6 renal cells by MAY, A, PUOTI, A, GAEGGELER, H.-P, HORISBERGER, J.-D, ROSSIER, B. C

“…Transepithelial Na+ reabsorption across tight epithelia is regulated by aldosterone. The amiloride-sensitive epithelial sodium channel (ENaC) is a major target…”
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Integrated microsystem for non-invasive electrophysiological measurements on Xenopus oocytes by Dahan, E., Bize, V., Lehnert, T., Horisberger, J.-D., Gijs, M.A.M.

“…We propose a new non-invasive integrated microsystem for electrophysiological measurements on Xenopus laevis oocytes. Xenopus oocyte is a well-known expression…”
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Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination by Staub, Olivier, Abriel, Hugues, Plant, Pamela, Ishikawa, Toru, Kanelis, Voula, Saleki, Reza, Horisberger, Jean-Daniel, Schild, Laurent, Rotin, Daniela

“…Regulation of the endothelial Na+ channel by Nedd4 and by ubiquitination. The epithelial Na+ channel (ENaC) is comprised of three subunits, α, β and γ, and…”
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The γ subunit is a specific component of the Na,K-ATPase and modulates its transport function by Béguin, Pascal, Wang, Xinyu, Firsov, Dimitri, Puoti, Alessandro, Claeys, Dirk, Horisberger, Jean-Daniel, Geering, Käthi

“…The role of small, hydrophobic peptides that are associated with ion pumps or channels is still poorly understood. By using the Xenopus oocyte as an expression…”
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A mouse model for Liddle's syndrome by PRADERVAND, S, QING WANG, BURNIER, M, BEERMANN, F, HORISBERGER, J. D, HUMMLER, E, ROSSIER, B. C

“…Liddle's syndrome (or pseudoaldosteronism) is an autosomal dominant form of salt-sensitive hypertension, due to abnormal sodium transport by the renal tubule…”
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Modular microsystem for epithelial cell culture and electrical characterisation by Hediger, S., Sayah, A., Horisberger, J.D., Gijs, M.A.M.

“…We have realised a microsystem for the culture and electrical characterisation of epithelial cell layers for cell-based diagnostic applications. The main goal…”
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The highly selective low-conductance epithelial Na channel of Xenopus laevis A6 kidney cells by Puoti, A, May, A, Canessa, C M, Horisberger, J D, Schild, L, Rossier, B C

“…In Na-reabsorbing tight epithelia, the rate-limiting step for Na transport is the highly selective low-conductance amiloride-sensitive epithelial Na channel…”
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Structure-function relationship of Na, K-ATPase by HORISBERGER, J.-D, LEMAS, V, KRAEHENBUÊHL, J.-P, ROSSIER, B. C

“…The aim of the present review is to examine critically (a) the molecular evidence for structural heterogeneity for both alpha and beta subunits; (b) the…”
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A Mouse Model for the Renal Salt-Wasting Syndrome Pseudohypoaldosteronism by Hummler, Edith, Barker, Pierre, Talbot, Colleen, Wang, Qing, Verdumo, Chantal, Grubb, Barbara, Gatzy, John, Burnier, Michel, Horisberger, Jean-Daniel, Beermann, Friedrich, Boucher, Richard, Rossier, Bernard C.

“…Aldosterone-dependent epithelial sodium transport in the distal nephron is mediated by the absorption of sodium through the highly selective,…”
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Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump by JAISSER, F, CANESSA, C. M, HORISBERGER, J.-D, ROSSIER, B. C

“…In order to understand the molecular mechanism of ouabain resistance in the toad Bufo marinus, Na,K-ATPase alpha and beta subunits have been cloned and their…”
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Effects of 8-cpt-cAMP on the epithelial sodium channel expressed in Xenopus oocytes by Chraïbi, A, Schnizler, M, Clauss, W, Horisberger, J D

“…Vasopressin stimulates the activity of the epithelial Na channel (ENaC) through the cAMP/PKA pathway in the cortical collecting tubule, or in similar amphibian…”
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Mutation of a cysteine in the first transmembrane segment of Na,K‐ATPase alpha subunit confers ouabain resistance by Canessa, C.M., Horisberger, J.D., Louvard, D., Rossier, B.C.

“…The cardiac glycoside ouabain inhibits Na,K‐ATPase by binding to the alpha subunit. In a highly ouabain resistant clone from the MDCK cell line, we have found…”
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Mechanisms of Urinary K+ and H+ Excretion: Primary Structure and Functional Expression of a Novel H, K-ATPase by Jaisser, Frédéric, Horisberger, Jean-Daniel, Geering, Käthi, Rossier, Bernard C.

“…The kidney plays an essential role in regulating potassium and acid balance. A major site for these regulations is in the collecting tubule. In the present…”
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Modulation of the Na,K-pump function by β subunit isoforms by JAISSER, F, JAUNIN, P, GEERING, K, ROSSIER, B. C, HORISBERGER, J.-D

“…To study the role of the Na,K-ATPase beta subunit in the ion transport activity, we have coexpressed the Bufo alpha 1 subunit (alpha 1) with three different…”
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Primary structure and functional expression of the mouse and frog alpha-subunit of the gastric H(+)-K(+)-ATPase by Mathews, P M, Claeys, D, Jaisser, F, Geering, K, Horisberger, J D, Kraehenbuhl, J P, Rossier, B C

“…The H(+)-K(+)-ATPase of the gastric parietal cells is responsible for the acidification of the stomach lumen. This heterodimeric protein belongs to the family…”
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A conformation of Na(+)-K+ pump is permeable to proton by Wang, X, Horisberger, J D

“…The Na(+)-K+ pump is thought to operate through a two-conformation (E1-E2) transport cycle in which the cation binding sites are accessible only from one side…”
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