Search Results - "Horioka, Kie"

Amphiregulin is overexpressed in human cardiac tissue in hypothermia deaths; associations between the transcript and stress hormone levels in cardiac deaths by Porvari, Katja, Horioka, Kie, Kaija, Helena, Pakanen, Lasse

“…Amphiregulin (AREG) is a growth factor linked to cardioprotection and heart pathology during myocardial stress. Our aim was to investigate cardiac AREG…”
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Acute Colchicine Poisoning Causes Endotoxemia via the Destruction of Intestinal Barrier Function: The Curative Effect of Endotoxin Prevention in a Murine Model by Horioka, Kie, Tanaka, Hiroki, Isozaki, Shotaro, Konishi, Hiroaki, Fujiya, Mikihiro, Okuda, Katsuhiro, Asari, Masaru, Shiono, Hiroshi, Ogawa, Katsuhiro, Shimizu, Keiko

“…Background Colchicine binds to intracellular tubulin and prevents mitosis. Colchicine is also used as an anti-inflammatory drug. Meanwhile, excess…”
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Soluble thrombomodulin ameliorates aberrant hemostasis after rewarming in a rat accidental hypothermia model by Takauji, Shuhei, Tanaka, Hiroki, Hayakawa, Mineji, Horioka, Kie, Isozaki, Shotaro, Konishi, Hiroaki

“…Accidental hypothermia (AH) sometimes leads to coagulation disorder, especially in severe AH. We previously demonstrated that intrasplenic platelet activation…”
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Biomarker patterns and mechanistic insights into hypothermia from a postmortem metabolomics investigation by Elmsjö, Albert, Ward, Liam J., Horioka, Kie, Watanabe, Shimpei, Kugelberg, Fredrik C., Druid, Henrik, Green, Henrik

“…Postmortem metabolomics holds promise for identifying crucial biological markers relevant to death investigations and clinical scenarios. We aimed to assess…”
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Hypothermia‐induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model by Horioka, Kie, Tanaka, Hiroki, Isozaki, Shotaro, Okuda, Katsuhiro, Asari, Masaru, Shiono, Hiroshi, Ogawa, Katsuhiro, Shimizu, Keiko

“…Background Hypothermia, either therapeutically induced or accidental (ie, an involuntary decrease in core body temperature to <35°C), results in hemostatic…”
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Overproduction of thrombopoietin by BRAFV600E‐mutated mouse hepatocytes and contribution of thrombopoietin to hepatocarcinogenesis by Tanaka, Hiroki, Horioka, Kie, Yamamoto, Masahiro, Asari, Masaru, Okuda, Katsuhiro, Yamazaki, Kosuke, Shimizu, Keiko, Ogawa, Katsuhiro

“…In hepatocarcinogenesis induced by diethylnitrosamine (DEN) in B6C3F1 mice, the BrafV637E mutation, corresponding to the human BRAFV600E mutation, plays a…”
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Low temperature induces von-willebrand factor expression via increased early growth response 1 transcriptional activity in splenic sinusoidal endothelial cells by Horioka, Kie, Tanaka, Hiroki, Isozaki, Shotaro, Konishi, Hiroaki, Addo, Lynda, Takauji, Shuhei, Druid, Henrik

“…von Willebrand factor (vWF) is a large plasma glycoprotein that plays an important role in hemostasis by forming molecular bridges with platelets following…”
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Hypothermia causes platelet activation in the human spleen by Horioka, Kie, Tanaka, Hiroki, Okaba, Keisuke, Yamada, Shinnosuke, Ishii, Namiko, Motomura, Ayumi, Inoue, Hiroyuki, Alkass, Kanar, Druid, Henrik, Yajima, Daisuke

“…Accidental hypothermia results in various dysfunctions in the human body. Additionally, coagulation disorder can lead to a life-threatening condition. We…”
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Rewarming from accidental hypothermia enhances whole blood clotting properties in a murine model by Horioka, Kie, Tanaka, Hiroki, Isozaki, Shotaro, Konishi, Hiroaki, Addo, Lynda, Takauji, Shuhei, Druid, Henrik

“…Hypothermia triggers coagulation, which can lead to the development of a life-threatening condition. We previously reported that hypothermia induces platelet…”
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Assessment of DNA degradation of buccal cells under humid conditions and DNA repair by DOP-PCR using locked nucleic acids by Asari, Masaru, Matsuura, Hiroaki, Isozaki, Shotaro, Hoshina, Chisato, Okuda, Katsuhiro, Tanaka, Hiroki, Horioka, Kie, Shiono, Hiroshi, Shimizu, Keiko

“…•The effect of humid conditions was evaluated based on two degradation ratios.•At 25 °C, the humidity significantly decreased 129:41- and 305:41-bp ratios…”
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High titers of infectious SARS-CoV-2 in corpses of patients with COVID-19 by Saitoh, Hisako, Sakai-Tagawa, Yuko, Nagasawa, Sayaka, Torimitsu, Suguru, Kubota, Kazumi, Hirata, Yuichiro, Iwatsuki-Horimoto, Kiyoko, Motomura, Ayumi, Ishii, Namiko, Okaba, Keisuke, Horioka, Kie, Abe, Hiroyuki, Ikemura, Masako, Rokutan, Hirofumi, Hinata, Munetoshi, Iwasaki, Akiko, Yasunaga, Yoichi, Nakajima, Makoto, Yamaguchi, Rutsuko, Tsuneya, Shigeki, Kira, Kei, Kobayashi, Susumu, Inokuchi, Go, Chiba, Fumiko, Hoshioka, Yumi, Mori, Aika, Yamamoto, Isao, Nakagawa, Kimiko, Katano, Harutaka, Iida, Shun, Suzuki, Tadaki, Akitomi, Shinji, Hasegawa, Iwao, Ushiku, Tetsuo, Yajima, Daisuke, Iwase, Hirotaro, Makino, Yohsuke, Kawaoka, Yoshihiro

“…•Infectious SARS-CoV-2 remained in 55% (6/11) corpses and 43% (13/30) specimens.•The highest infectious titer was 2.09E + 06 plaque-forming units/g in corpse…”
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Multidirectional analysis for a colchicine poisoning case revealed detail cause of death and its mechanism by Okuda, Katsuhiro, Isozaki, Shotaro, Asari, Masaru, Tanaka, Hiroki, Horioka, Kie, Takahashi, Yuta, Hoshina, Chisato, Yamada, Hiromi, Mori, Kanae, Namba, Ryo, Shiono, Hiroshi, Ogawa, Katsuhiro, Shimizu, Keiko

“…•Tissue distribution of colchicine in humans died of acute colchicine poisoning.•Genetic analysis of stomach contents to reveal ingestion of Meadow…”
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Post-traumatic cerebral infarction caused by thrombus in the middle cerebral artery by Hayakawa, Akira, Sano, Rie, Takahashi, Yoichiro, Fukuda, Haruki, Okawa, Takafumi, Kubo, Rieko, Takei, Hiroyuki, Komatsu, Takakazu, Tokue, Hiroyuki, Sawada, Yusuke, Oshima, Kiyohiro, Horioka, Kie, Kominato, Yoshihiko

“…A woman in her 80s was found unconscious after being hit by a car while crossing a road. After admission to hospitals, computed tomography (CT) scans revealed…”
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Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Thiosulfate in Human Blood and Urine as an Indicator of Hydrogen Sulfide Poisoning by Maseda, Chikatoshi, Hayakawa, Akira, Okuda, Katsuhiro, Asari, Masaru, Tanaka, Hiroki, Yamada, Hiromi, Jin, Shigeki, Horioka, Kie, Matoba, Kotaro, Shiono, Hiroshi, Matsubara, Kazuo, Shimizu, Keiko

“…Highlights • Quantitative determination method for thiosulfate by LC-MS/MS was developed. • Thiosulfate can be utilized for an index of hydrogen sulfide…”
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Discrimination of haplotype in mitochondrial DNA mixtures using LNA-mediated PCR clamping by Asari, Masaru, Isozaki, Shotaro, Hoshina, Chisato, Okuda, Katsuhiro, Tanaka, Hiroki, Horioka, Kie, Shiono, Hiroshi, Shimizu, Keiko

“…•We developed a discrimination method of mtDNA mixtures by PCR clamping using LNA.•The specificity of LNA-containing probes was evaluated by predicting Tm…”
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Chained nuclei and python pattern in skeletal muscle cells as histological markers for electrical injury by Tanaka, Hiroki, Okuda, Katsuhiro, Ohtani, Seiji, Asari, Masaru, Horioka, Kie, Isozaki, Shotaro, Hayakawa, Akira, Ogawa, Katsuhiro, Hiroshi, Shiono, Shimizu, Keiko

“…•Python pattern and chained nuclear change are uniquely observed in the skeletal muscle of patients with electrical injury.•The python pattern was induced by…”
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Appropriate blood sampling sites for measuring Tg concentrations for forensic diagnosis by Hayakawa, Akira, Matoba, Kotaro, Horioka, Kie, Murakami, Manabu, Terazawa, Koichi

“…Highlights • We analyzed the cases without the findings presumed to increase Tg concentration in the previous studies. • Tg concentration in venous blood was…”
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Unreliability of the use of thyroglobulin concentration in postmortem blood samples in forensic diagnosis by Hayakawa, Akira, Matoba, Kotaro, Horioka, Kie, Murakami, Manabu, Terazawa, Koichi

“…Abstract Previous studies have reported that the concentration of thyroglobulin (Tg) in heart blood is high in cases of asphyxia by neck compression such as…”
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Abstract 1162: Amelioration of the pathologic changes in the hepatocyte-specific BRAF V600E mutated mice by administration of aspirin by Tanaka, Hiroki, Horioka, Kie, Yamamoto, Masahiro, Yamazaki, Kosuke, Ogawa, Katsuhiro

“…Abstract We previously reported that the BrafV637E mutation, corresponding to the human BRAFV600E mutation, plays a pivotal role in hepatocarcinogenesis…”
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Bioprotective Role of Platelet-Derived Microvesicles in Hypothermia: Insights from the Differential Characteristics of Peripheral and Splenic Platelets by Horioka, Kie, Tanaka, Hiroki, Ikuta, Katsuya

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