Search Results - "Horii, Ikuo"

The principle of safety evaluation in medicinal drug - how can toxicology contribute to drug discovery and development as a multidisciplinary science? by Horii, Ikuo

“…Pharmaceutical (drug) safety assessment covers a diverse science-field in the drug discovery and development including the post-approval and post-marketing…”
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Current status and future perspective of computational toxicology in drug safety assessment under ontological intellection by Yamagata, Yuki, Yamada, Hiroshi, Horii, Ikuo

“…For the safety assessment of pharmaceuticals, initial data management requires accurate toxicological data acquisition, which is based on regulatory safety…”
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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact by Kopec, Anna K., Yokokawa, Ryuji, Khan, Nasir, Horii, Ikuo, Finley, James E., Bono, Christine P., Donovan, Carol, Roy, Jessica, Harney, Julie, Burdick, Andrew D., Jessen, Bart, Lu, Shuyan, Collinge, Mark, Sadeghian, Ramin Banan, Derzi, Mazin, Tomlinson, Lindsay, Burkhardt, John E.

“…Microphysiological systems (MPS) are making advances to provide more standardized and predictive physiologically relevant responses to test articles in living…”
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Toxic effect onset and evaluations of medicinal drugs - horizon for Darwinian toxicological thought by Horii, Ikuo

“…The theory of Darwinian Medicine linked to an extension of Darwin’s evolutionary theory is based on the approach from the aspect of “why we become ill?”. This…”
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CHANGES OF MICRO-RNA EXPRESSION IN RAT LIVER TREATED BY ACETAMINOPHEN OR CARBON TETRACHLORIDE − REGULATING ROLE OF MICRO-RNA FOR RNA EXPRESSION by FUKUSHIMA, Tamio, HAMADA, Yoshimasa, YAMADA, Hiroshi, HORII, Ikuo

“…Recently, microRNAs, involved in RNA interference, were discovered as a new gene regulation, with little is known in the filed of toxicology. In this study, a…”
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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors by Nakayama, K, Ishida, N, Shirane, M, Inomata, A, Inoue, T, Shishido, N, Horii, I, Loh, D Y, Nakayama, K

“…Mice lacking p27(Kip1) have been created by gene targeting in embryonic stem cells. These mice are larger than the control animals, with thymus, pituitary, and…”
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Microarray analysis of 6-mercaptopurine-induced-toxicity-related genes and microRNAs in the rat placenta by Taki, Kenji, Fukushima, Tamio, Ise, Ryota, Horii, Ikuo, Yoshida, Takemi

“…MicroRNAs (miRNAs) are small single-stranded RNAs of 19-25 nucleotides and are important in posttranscriptional regulation of genes. Recently, the role of…”
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INVESTIGATION OF A HEPATOTOXICITY SCREENING SYSTEM IN PRIMARY CELL CULTURES -"WHAT BIOMARKERS WOULD NEED TO BE ADDRESSED TO ESTIMATE TOXICITY IN CONVENTIONAL AND NEW APPROACHES?" by KIKKAWA, Rie, YAMAMOTO, Toshinori, FUKUSHIMA, Tamio, YAMADA, Hiroshi, HORII, Ikuo

“…High throughput toxicological estimation is required for safety evaluation in the early stage of drug discovery. In this context, establishment of an in vitro…”
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MicroRNAs expression in the Ethylene Glycol Monomethyl Ether-induced testicular lesion by Fukushima, Tamio, Taki, Kenji, Ise, Ryota, Horii, Ikuo, Yoshida, Takemi

“…Ethylene glycol monomethyl ether (EGME) induces testicular lesion in rats and human. To investigate miRNAs expression in EGME testicular lesion, miRNA array…”
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IN VIVO HEPATOTOXICITY STUDY OF RATS IN COMPARISON WITH IN VITRO HEPATOTOXICITY SCREENING SYSTEM by KIKKAWA, Rie, FUJIKAWA, Masaaki, YAMAMOTO, Toshinori, HAMADA, Yoshimasa, YAMADA, Hiroshi, HORII, Ikuo

“…For the establishment of a high throughput screening system using primary cell cultures, investigation of elucidated toxicities to assess the correlation…”
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PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL by TOMIZAWA, Kaori, SUGANO, Kiyohiko, YAMADA, Hiroshi, HORII

“…Some of the principal requisites of toxicity screening methods in drug discovery are their ease to perform and high throughput, as well as the possibility to…”
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ADVANTAGES OF IN VITRO CYTOTOXICITY TESTING BY USING PRIMARY RAT HEPATOCYTES IN COMPARISON WITH ESTABLISHED CELL LINES by WANG, Kun, SHINDOH, Hidetoshi, INOUE, Tomoaki, HORII, Ikuo

“…We investigated and compared the cytotoxicity of 16 reference compounds in four in vitro systems: primary cultured rat hepatocytes, hepatoma HepG2 cell line,…”
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6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta by Taki, Kenji, Fukushima, Tamio, Ise, Ryota, Horii, Ikuo, Yoshida, Takemi

“…The placenta secures the embryo and fetus to the endometrium and releases a variety of steroid and peptide hormones that convert the physiology of a female to…”
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INVESTIGATION OF PROTEOMIC BIOMARKERS IN IN VIVO HEPATOTOXICITY STUDY OF RAT LIVER: TOXICITY DIFFERENTIATION IN HEPATOTOXICANTS by YAMAMOTO, Toshinori, KIKKAWA, Rie, YAMADA, Hiroshi, HORII, Ikuo

“…We investigated the overall protein expression profiles in the in vivo hepatotoxicity of rats induced by four well-recognized hepatotoxicants. Acetaminophen…”
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INTEGRATED NMR-BASED METABONOMIC INVESTIGATION OF EARLY METABOLIC EFFECTS OF ETHYLENE GLYCOL MONOMETHYL ETHER (EGME) ON MALE REPRODUCTIVE ORGANS IN RATS by YAMAMOTO, Toshinori, HORII, Ikuo, YOSHIDA, Takemi

“…High-resolution Magic Angle Spinning (Hr-MAS) 1H-NMR spectroscopy was used to analyze intact testicular tissues ex vivo and to investigate the toxicological…”
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IDENTIFICATION OF OXIDATIVE STRESS-RELATED PROTEINS FOR PREDICTIVE SCREENING OF HEPATOTOXICITY USING A PROTEOMIC APPROACH by YAMAMOTO, Toshinori, KIKKAWA, Rie, YAMADA, Hiroshi, HORII, Ikuo

“…We investigated the effects of three hepatotoxicants, acetaminophen (APAP), amiodarone (AD) and tetracycline (TC), on protein expression in primary cultured…”
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Human Hepatocytes Can Repopulate Mouse Liver: Histopathology of the Liver in Human Hepatocyte-Transplanted Chimeric Mice and Toxicologic Responses to Acetaminophen by Sato, Yasushi, Yamada, Hiroshi, Iwasaki, Kazuhide, Tateno, Chise, Yokoi, Tsuyoshi, Yoshizato, Katsutoshi, Horii, Ikuo

“…A human hepatocyte-transplanted chimeric mouse has been established by transplantation of human hepatocytes to urokinase-type plasminogen activator…”
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Effects of Sulfasalazine on Sperm Acrosome Reaction and Gene Expression in the Male Reproductive Organs of Rats by Fukushima, Tamio, Kato, Masashi, Adachi, Tetsuya, Hamada, Yoshimasa, Horimoto, Masao, Komiyama, Masatoshi, Mori, Chisato, Horii, Ikuo

“…Sulfasalazine (SASP) has been reported to depress the fertility in men and experimental male animals, but the fundamental mechanisms of infertility caused by…”
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The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, Capecitabine by SHIMMA, N, UMEDA, I, KURUMA, I, HORII, I, ISHITSUKA, H, ARASAKI, M, MURASAKI, C, MASUBUCHI, K, KOHCHI, Y, MIWA, M, URA, M, SAWADA, N, TAHARA, H

“…To identify an orally available fluoropyrimidine having efficacy and safety profiles greatly improved over those of parenteral 5-fluorouracil (5-FU: 1), we…”
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In vitro gene expression analysis of nephrotoxic drugs in rat primary renal cortical tubular cells by Suzuki, Hiromi, Inoue, Tomoaki, Matsushita, Tomochika, Kobayashi, Kazuko, Horii, Ikuo, Hirabayashi, Yoko, Inoue, Tohru

“…Rat primary renal cortical tubular cells were exposed to seven test substances, some with, and some without, known direct renal tubular cell toxicity. Cells…”
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