Search Results - "Horigome, Kazuhiko"

Neofunction of ACVR1 in fibrodysplasia ossificans progressiva by Hino, Kyosuke, Ikeya, Makoto, Horigome, Kazuhiko, Matsumoto, Yoshihisa, Ebise, Hayao, Nishio, Megumi, Sekiguchi, Kazuya, Shibata, Mitsuaki, Nagata, Sanae, Matsud, Shuichi, Toguchida, Junya

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by extraskeletal bone formation through endochondral ossification. FOP…”
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Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva by Hino, Kyosuke, Horigome, Kazuhiko, Nishio, Megumi, Komura, Shingo, Nagata, Sanae, Zhao, Chengzhu, Jin, Yonghui, Kawakami, Koichi, Yamada, Yasuhiro, Ohta, Akira, Toguchida, Junya, Ikeya, Makoto

“…Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disease characterized by extraskeletal bone formation through endochondral ossification…”
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New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva by Matsumoto, Yoshihisa, Ikeya, Makoto, Hino, Kyosuke, Horigome, Kazuhiko, Fukuta, Makoto, Watanabe, Makoto, Nagata, Sanae, Yamamoto, Takuya, Otsuka, Takanobu, Toguchida, Junya

“…Successful in vitro disease‐recapitulation using patient‐specific induced pluripotent stem cells (iPSCs) requires two fundamental technical issues: appropriate…”
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An mTOR Signaling Modulator Suppressed Heterotopic Ossification of Fibrodysplasia Ossificans Progressiva by Hino, Kyosuke, Zhao, Chengzhu, Horigome, Kazuhiko, Nishio, Megumi, Okanishi, Yasue, Nagata, Sanae, Komura, Shingo, Yamada, Yasuhiro, Toguchida, Junya, Ohta, Akira, Ikeya, Makoto

“…Fibrodysplasia ossificans progressiva (FOP) is a rare and intractable disorder characterized by extraskeletal bone formation through endochondral ossification…”
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Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation by Ito, A, Horigome, K

“…We examined the ability of ceramide and sphingomyelinase (SMase) to prevent neuronal programmed cell death (PCD). We found that a cell-permeable ceramide…”
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Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism by Ota, Shinichi, Horigome, Kazuhiko, Ishii, Takayuki, Nakai, Michio, Hayashi, Koji, Kawamura, Takao, Kishino, Akiyoshi, Taiji, Mutsuo, Kimura, Toru

“…Metformin is widely used as a hypoglycemic agent for the treatment of type 2 diabetes. Both metformin and rotenone, an inhibitor of respiratory chain complex…”
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Enhanced Chondrogenesis of Induced Pluripotent Stem Cells From Patients With Neonatal‐Onset Multisystem Inflammatory Disease Occurs via the Caspase 1–Independent cAMP/Protein Kinase A/CREB Pathway by Yokoyama, Koji, Ikeya, Makoto, Umeda, Katsutsugu, Oda, Hirotsugu, Nodomi, Seishiro, Nasu, Akira, Matsumoto, Yoshihisa, Izawa, Kazushi, Horigome, Kazuhiko, Kusaka, Toshimasa, Tanaka, Takayuki, Saito, Megumu K., Yasumi, Takahiro, Nishikomori, Ryuta, Ohara, Osamu, Nakayama, Naoki, Nakahata, Tatsutoshi, Heike, Toshio, Toguchida, Junya

“…Objective Neonatal‐onset multisystem inflammatory disease (NOMID) is a dominantly inherited autoinflammatory disease caused by NLRP3 mutations. NOMID…”
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Selective release of phospholipase A2 and lysophosphatidylserine-specific lysophospholipase from rat platelets by Horigome, K, Hayakawa, M, Inoue, K, Nojima, S

“…Rat platelets released phospholipase A2 and lysophospholipase upon activation with thrombin or ADP. The release of phospholipases was energy-dependent and was…”
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Purification and characterization of phospholipase A2 released from rat platelets by Horigome, K, Hayakawa, M, Inoue, K, Nojima, S

“…It was found that phospholipase A2 and lysophospholipase, both of which were released from thrombin-stimulated rat platelets, had high affinity to…”
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Purification of rabbit platelet secretory phospholipase A2 and its characteristics by Mizushima, H, Kudo, I, Horigome, K, Murakami, M, Hayakawa, M, Kim, D K, Kondo, E, Tomita, M, Inoue, K

“…It was reported previously that rat platelets release phospholipase A2 upon in vitro stimulation by thrombin, ADP, or A23187 (Horigome, K., Hayakawa, M.,…”
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Amino acid composition and NH2-terminal amino acid sequence of rat platelet secretory phospholipase A2 by Hayakawa, M, Horigome, K, Kudo, I, Tomita, M, Nojima, S, Inoue, K

“…The amino acid composition and partial NH2-terminal amino acid sequence of the phospholipase A2 secreted by stimulated rat platelets were determined. The most…”
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Effect of serine phospholipid structure on the enhancement of concanavalin A-induced degranulation in rat mast cells by Horigome, K, Tamori-Natori, Y, Inoue, K, Nojima, S

“…The correlations among the potentiating activity of various PS analogs on concanavalin A (Con A)-induced rat mast cell degranulation, the hemolytic activity…”
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CLAC Binds to Aggregated Aβ and Aβ Fragments, and Attenuates Fibril Elongation by Kakuyama, Hiroyoshi, Söderberg, Linda, Horigome, Kazuhiko, Winblad, Bengt, Dahlqvist, Camilla, Näslund, Jan, Tjernberg, Lars O.

“…Deposition of amyloid β-peptide (Aβ) into amyloid plaques is one of the invariant neuropathological features of Alzheimer's disease. Proteins that codeposit…”
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Metabolism of lysophosphatidylserine, a potentiator of histamine release in rat mast cells by Tamori-Natori, Y, Horigome, K, Inoue, K, Nojima, S

“…Lysophosphatidylserine (lysoPS) strongly enhances degranulation of rat mast cells induced by concanavalin A (Con A). In the present paper, the metabolism of…”
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SMP-534 inhibits TGF-beta-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis by Sugaru, Eiji, Sakai, Mutsuko, Horigome, Kazuhiko, Tokunaga, Teruhisa, Kitoh, Makoto, Hume, W Ewan, Nagata, Ryu, Nakagawa, Tsutomu, Taiji, Mutsuo

“…Transforming growth factor-beta (TGF-beta) is a potent fibrotic factor responsible for the synthesis of extracellular matrix (ECM) and is implicated as the…”
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Biochemical characterization of programmed cell death in NGF-deprived sympathetic neurons by Martin, D P, Ito, A, Horigome, K, Lampe, P A, Johnson, Jr, E M

“…Young sympathetic neurons die when deprived of nerve growth factor (NGF). Under such circumstances, cell death is appropriate to the developing nervous system…”
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Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation by K Horigome, J C Pryor, E D Bullock, E M Johnson, Jr

“…Nerve growth factor causes mediator release from rat peritoneal mass cells in the presence of lysophosphatidylserine. We have investigated the neurotrophin and…”
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CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation by Kakuyama, Hiroyoshi, Söderberg, Linda, Horigome, Kazuhiko, Winblad, Bengt, Dahlqvist, Camilla, Näslund, Jan, Tjernberg, Lars O

“…Deposition of amyloid beta-peptide (Abeta) into amyloid plaques is one of the invariant neuropathological features of Alzheimer's disease. Proteins that…”
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Effects of nerve growth factor on rat peritoneal mast cells. Survival promotion and immediate-early gene induction by K Horigome, E D Bullock, E M Johnson, Jr

“…Purified rat peritoneal mast cells in vitro die over a period of 2-6 days in conventional serum-containing medium. As mast cells die, they become pyknotic and…”
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Cell death genes in invertebrates and (maybe) vertebrates by Freeman, R S, Estus, S, Horigome, K, Johnson, Jr, E M

“…That naturally occurring cell death in the nervous and other systems is an active and physiologically appropriate process has received much attention recently…”
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