Search Results - "Horie, Yoshiharu"

Effect of COVID-19 Infection on Presenteeism by Miyaji Chikara, Kobayashi Tomoko, Habu Hiroshi, Hagiyama Akikazu, Horie Yoshiharu, Soshi, Takao

“…ObjectivePresenteeism occurs when employees attend work despite experiencing problems and ill-health that require sick leave. This study examined whether…”
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Investigation of time profile of FEV1 across the onset of potential COPD: a retrospective cohort study using medical checkup data in Japan by Suzuki, Masaru, Matsumoto, Isao, Ishida, Masato, Horie, Yoshiharu, Ban, Hideyuki, Takeuchi, Wataru, Nakagawa, Shunki, Nakagawa, Tohru, Kitamura, Tetsuhisa, Muro, Shigeo

“…This study compared the time profile of FEV 1 after COPD diagnosis among rapid decliners, slow decliners, and sustainers in the year of COPD diagnosis. COPD…”
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Machine Learning Methods for the Diagnosis of Chronic Obstructive Pulmonary Disease in Healthy Subjects: Retrospective Observational Cohort Study by Muro, Shigeo, Ishida, Masato, Horie, Yoshiharu, Takeuchi, Wataru, Nakagawa, Shunki, Ban, Hideyuki, Nakagawa, Tohru, Kitamura, Tetsuhisa

“…Background Airflow limitation is a critical physiological feature in chronic obstructive pulmonary disease (COPD), for which long-term exposure to noxious…”
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Pharmacokinetic, Pharmacodynamic, and Tolerability Profiles of the Dipeptidyl Peptidase-4 Inhibitor Linagliptin: A 4-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IIa Study in Japanese Type 2 Diabetes Patients by Horie, Yoshiharu, PhD, Kanada, Shigeto, MD, Watada, Hirotaka, MD, Sarashina, Akiko, MSc, Taniguchi, Atsushi, MSc, Hayashi, Naoyuki, MSc, Graefe-Mody, Eva U., PhD, Woerle, Hans-Juergen, MD, Dugi, Klaus A., MD

“…Abstract Background The dipeptidyl-peptidase-4 (DPP-4) inhibitor linagliptin is under clinical development for treatment of type 2 diabetes mellitus (T2DM). In…”
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The Effects of an Uninterrupted Switch from Donepezil to Galantamine without Dose Titration on Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease by Sasaki, Shoichi, Horie, Yoshiharu

“…Aims: To elucidate the efficacy of galantamine on cognition and behavioral and psychological symptoms of dementia (BPSD) in outpatients with mild cognitive…”
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Linagliptin, a dipeptidyl peptidase-4 inhibitor in development for the treatment of type 2 diabetes mellitus: A phase I, randomized, double-blind, placebo-controlled trial of single and multiple escalating doses in healthy adult male japanese subjects by Sarashina, Akiko, MSc, Sesoko, Shogo, MD, Nakashima, Mitsuyoshi, MD, Hayashi, Naoyuki, MSc, Taniguchi, Atsushi, MSc, Horie, Yoshiharu, PhD, Graefe-Mody, Eva U., PhD, Woerle, Hans-Juergen, MD, Dugi, Klaus A., MD

“…Abstract Background: The dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin is in clinical development for the treatment of type 2 diabetes mellitus (T2DM)…”
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Comparable pharmacodynamics, efficacy, and safety of linagliptin 5 mg among Japanese, Asian and white patients with type 2 diabetes by Sarashina, Akiko, Friedrich, Christian, Crowe, Susanne, Patel, Sanjay, Graefe‐Mody, Ulrike, Hayashi, Naoyuki, Horie, Yoshiharu

“…Aims/Introduction The efficacy and safety of drugs can vary between different races or ethnic populations because of differences in the relationship of dose to…”
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Design, statistical analysis and sample size calculation of a phase IIb/III study of linagliptin versus voglibose and placebo by Horie, Yoshiharu, Hayashi, Naoyuki, Dugi, Klaus, Takeuchi, Masahiro

“…Many patients with diabetes mellitus (DM) require a combination of antidiabetic drugs with complementary mechanisms of action to lower their hemoglobin A1c…”
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Renoprotective effects of telmisartan in the 5/6 nephrectomised rats by Tsunenari, Ichiro, Ohmura, Tsuyoshi, Seidler, Randolph, Chachin, Motohiko, Hayashi, Toshihiro, Konomi, Ayako, Matsumaru, Takehisa, Sumida, Toshiyuki, Hayashi, Naoyuki, Horie, Yoshiharu

“…The purpose of this study was to investigate the renoprotective effect of telmisartan on the advanced stages of nephropathy in rats with 5/6 nephrectomy (5/6…”
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Association Between Olfactory Impairment and Disease Severity and Duration in Parkinson's Disease by Sasaki, Shoichi, Horie, Yoshiharu

“…ABSTRACT Background The association between olfactory dysfunction and disease duration and severity in Parkinson's disease (PD) remains controversial…”
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Effect of COVID-19 Infection on Presenteeism: Cohort Study Using Large Health Insurance-Based Data in Japan by Miyaji, Chikara, Kobayashi, Tomoko, Habu, Hiroshi, Hagiyama, Akikazu, Horie, Yoshiharu, Takao, Soshi

“…Presenteeism occurs when employees attend work despite experiencing problems and ill-health that require sick leave. This study examined whether presenteeism…”
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Impact of COVID-19 Infection on Health-Related Quality of Life in the Japanese Population: A Large Health-Insurance-Based Database Study by Kobayashi, Tomoko, Miyaji, Chikara, Habu, Hiroshi, Horie, Yoshiharu, Takao, Soshi

“…Evidence for acute or long-term coronavirus disease 2019 (COVID-19) infection is relatively limited. We aimed to evaluate the impact of COVID-19 infection on…”
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Mitochondrial alterations in dorsal root ganglion cells in sporadic amyotrophic lateral sclerosis by Sasaki, Shoichi, Horie, Yoshiharu, Iwata, Makoto

“…Little information is available regarding the morphological changes in the mitochondria in amyotrophic lateral sclerosis (ALS). In particular, mitochondrial…”
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The Japanese aggrenox (extended-release dipyridamole plus aspirin) stroke prevention versus aspirin programme (JASAP) study: a randomized, double-blind, controlled trial by Uchiyama, Shinichiro, Ikeda, Yasuo, Urano, Yasuhisa, Horie, Yoshiharu, Yamaguchi, Takenori

“…Despite improvements in treatment, stroke still carries a high death toll and disability in Asia. Extended-release dipyridamole (ER-DP) plus acetylsalicylic…”
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Investigation of time profile of FEV 1 across the onset of potential COPD: a retrospective cohort study using medical checkup data in Japan by Suzuki, Masaru, Matsumoto, Isao, Ishida, Masato, Horie, Yoshiharu, Ban, Hideyuki, Takeuchi, Wataru, Nakagawa, Shunki, Nakagawa, Tohru, Kitamura, Tetsuhisa, Muro, Shigeo

“…This study compared the time profile of FEV after COPD diagnosis among rapid decliners, slow decliners, and sustainers in the year of COPD diagnosis. COPD…”
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Abstract 2875: Effect of Mean, Maximum, and Variation of Blood Pressure in Patients with Ischemic Stroke during Antiplatelet Therapy by Uchiyama, Shinichiro, Ikeda, Yasuo, Horie, Yoshiharu, Urano, Yasuhisa, Yamaguchi, Takenori

“…Abstract only Background: The Japanese Aggrenox Stroke Prevention vs. Aspirin Programme (JASAP) study was a double-blind, randomized clinical trial to compare…”
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DIETHYL 1-FLUORO-1-PHENYLSULFONYLMETHANEPHOSPHONATE, A VERSATILE AGENT FOR THE PREPARATION OF MONOFLUORINATED BUILDING BLOCKS by Koizumi, Toru, Hagi, Toru, Horie, Yoshiharu, Takeuchi, Yoshio

“…Diethyl 1-fluoro-1-phenylsulfonylmethanephosphonate was prepared and was transformed into 1-fluoroalkanephosphonate and phenyl 1-fluorovinyl sulfones, which…”
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Pharmacokinetic, Pharmacodynamic, and Tolerability Profiles of the Dipeptidyl Peptidase-4 Inhibitor Linagliptin: A 4-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase IIa Study in Japanese Type 2 Diabetes Patients ⁎ ⁎ Data from this study were presented, in part, at the American Diabetes Association, 68th Scientific Sessions, San Francisco, California, June 9–13, 2008 (poster 0533P), and at the 52nd Annual Meeting of the Japan Diabetes Society, Osaka, Japan, May 21–24, 2009 (p by Horie, Yoshiharu, Kanada, Shigeto, Watada, Hirotaka, Sarashina, Akiko, Taniguchi, Atsushi, Hayashi, Naoyuki, Graefe-Mody, Eva U., Woerle, Hans-Juergen, Dugi, Klaus A.

“…The dipeptidyl-peptidase-4 (DPP-4) inhibitor linagliptin is under clinical development for treatment of type 2 diabetes mellitus (T2DM). In previous studies in…”
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Design, statistical analysis and sample size calculation of dose response study of telmisartan and hydrochlorothiazide by Horie, Yoshiharu, Higaki, Jitsuo, Takeuchi, Masahiro

“…Abstract Many patients with hypertension take some antihypertensive drugs with complementary mechanisms of action to lower their blood pressure and achieve the…”
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DATA CRYSTALLIZATION APPLIED FOR DESIGNING NEW PRODUCTS by Horie, Kenichi, Maeno, Yoshiharu, Ohsawa, Yukio

“…It is only the observable part of the real world that can be stored in data. For such incomplete and ill-structured data, data crystallizing aims at presenting…”
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