Search Results - "Horgen, F. David"

The TRPM7 channel kinase regulates store‐operated calcium entry by Faouzi, Malika, Kilch, Tatiana, Horgen, F. David, Fleig, Andrea, Penner, Reinhold

“…Key points Pharmacological and molecular inhibition of transient receptor potential melastatin 7 (TRPM7) reduces store‐operated calcium entry (SOCE)…”
Get full text

Validation of ATR FT-IR to identify polymers of plastic marine debris, including those ingested by marine organisms by Jung, Melissa R., Horgen, F. David, Orski, Sara V., Rodriguez C., Viviana, Beers, Kathryn L., Balazs, George H., Jones, T. Todd, Work, Thierry M., Brignac, Kayla C., Royer, Sarah-Jeanne, Hyrenbach, K. David, Jensen, Brenda A., Lynch, Jennifer M.

“…Polymer identification of plastic marine debris can help identify its sources, degradation, and fate. We optimized and validated a fast, simple, and accessible…”
Get full text

Waixenicin A Inhibits Cell Proliferation through Magnesium-dependent Block of Transient Receptor Potential Melastatin 7 (TRPM7) Channels by Zierler, Susanna, Yao, Guangmin, Zhang, Zheng, Kuo, W. Cedric, Pörzgen, Peter, Penner, Reinhold, Horgen, F. David, Fleig, Andrea

“…Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnesium-uptake mechanism in mammalian cells and are key regulators of cell…”
Get full text

Isolation, Structure Determination, and Synthesis of Cyclic Tetraglutamic Acids from Box Jellyfish Species Alatina alata and Chironex yamaguchii by Reinicke, Justin, Kitatani, Ryuju, Masoud, Shadi Sedghi, Galbraith, Kelly Kawabata, Yoshida, Wesley, Igarashi, Ayako, Nagasawa, Kazuo, Berger, Gideon, Yanagihara, Angel, Nagai, Hiroshi, Horgen, F David

“…Cubozoan nematocyst venoms contain known cytolytic and hemolytic proteins, but small molecule components have not been previously reported from cubozoan venom…”
Get full text

TRPM7 Regulates Axonal Outgrowth and Maturation of Primary Hippocampal Neurons by Turlova, Ekaterina, Bae, Christine Y. J., Deurloo, Marielle, Chen, Wenliang, Barszczyk, Andrew, Horgen, F. David, Fleig, Andrea, Feng, Zhong-Ping, Sun, Hong-Shuo

“…Transient receptor potential melastatin 7 (TRPM7) is a calcium-permeable divalent cation channel and mediates neuronal cell death under ischemic stresses. In…”
Get full text

Waixenicin A, a marine-derived TRPM7 inhibitor: a promising CNS drug lead by Sun, Hong-Shuo, Horgen, F. David, Romo, Daniel, Hull, Kenneth G., Kiledal, Sigrid A., Fleig, Andrea, Feng, Zhong-Ping

“…Ion channels are the third largest class of targets for therapeutic drugs. The pharmacology of ion channels is an important research area for identifying new…”
Get full text

Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida by Luo, Zengwei, Wang, Fuqian, Zhang, Jinwen, Li, Xingyao, Zhang, Mengke, Hao, Xincai, Xue, Yongbo, Li, Yan, Horgen, F. David, Yao, Guangmin, Zhang, Yonghui

“…Seven new alkaloids, N-methylhemeanthidine chloride (1), N-methyl-5,6-dihydroplicane (5), O-methylnerinine (6), N-ethoxycarbonylethylcrinasiadine (7),…”
Get full text

Assessment of plastic ingestion by pole‐caught pelagic predatory fish from O'ahu, Hawai'i by Hyrenbach, K. David, McGinnis, Zora, Page, Kathleen, Rapp, Dan, Horgen, F. David, Lynch, Jennifer M.

“…Although the frequency of occurrence of plastic ingestion in the large‐sized dolphinfish and tunas taken by the Hawai'i longline fishery is very low (frequency…”
Get full text

The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity by Jansen, Chad, Sahni, Jaya, Suzuki, Sayuri, Horgen, F. David, Penner, Reinhold, Fleig, Andrea

“…TRPM7 is a member of the Transient-Receptor-Potential Melastatin ion channel family. TRPM7 is a unique fusion protein of an ion channel and an α-kinase…”
Get full text

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion by Sisquella, Xavier, Nebl, Thomas, Thompson, Jennifer K, Whitehead, Lachlan, Malpede, Brian M, Salinas, Nichole D, Rogers, Kelly, Tolia, Niraj H, Fleig, Andrea, O'Neill, Joseph, Tham, Wai-Hong, David Horgen, F, Cowman, Alan F

“…The most lethal form of malaria in humans is caused by . These parasites invade erythrocytes, a complex process involving multiple ligand-receptor…”
Get full text

Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation by Ma, Chi, Hoffmann, FuKun W., Marciel, Michael P., Page, Kathleen E., Williams-Aduja, Melodie A., Akana, Ellis N.L., Gojanovich, Greg S., Gerschenson, Mariana, Urschitz, Johann, Moisyadi, Stefan, Khadka, Vedbar S., Rozovsky, Sharon, Deng, Youping, Horgen, F. David, Hoffmann, Peter R.

“…T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine…”
Get full text

Drugs acting at TRPM7 channels inhibit seizure‐like activity by Khalil, Aytakin, Shekh‐Ahmad, Tawfeeq, Kovac, Stjepana, Wykes, Robert C., Horgen, F. David, Fleig, Andrea, Walker, Matthew C.

“…Transient receptor potential cation subfamily M7 (TRPM7) channels are ion channels permeable to divalent cations. They are abundantly expressed with…”
Get full text

Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice by Huang, Junhao, Furuya, Hideki, Faouzi, Malika, Zhang, Zheng, Monteilh-Zoller, Mahealani, Kawabata, Kelly Galbraith, Horgen, F David, Kawamori, Toshihiko, Penner, Reinhold, Fleig, Andrea

“…Magnesium (Mg ) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential…”
Get full text

Erratum to: Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice by Huang, Junhao, Furuya, Hideki, Faouzi, Malika, Zhang, Zheng, Monteilh-Zoller, Mahealani, Kawabata, Kelly Galbraith, David Horgen, F, Kawamori, Toshihiko, Penner, Reinhold, Fleig, Andrea

“…Unfortunately, after publication of this article [1], it was noticed that the names of Kelly Galbraith Kawabata and F. David Horgen were incorrectly presented…”
Get full text

Macrolactone Nuiapolide, Isolated from a Hawaiian Marine Cyanobacterium, Exhibits Anti-Chemotactic Activity by Mori, Shogo, Williams, Howard, Cagle, Davey, Karanovich, Kristopher, Horgen, F David, Smith, III, Roger, Watanabe, Coran M H

“…A new bioactive macrolactone, nuiapolide (1) was identified from a marine cyanobacterium collected off the coast of Niihau, near Lehua Rock. The natural…”
Get full text

STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration by Hammad, Ayat S., Yu, Fang, Al-Hamaq, Jawaher, Horgen, F. David, Machaca, Khaled

“…•STIM1 but not Orai1 knockout enhances migration and invasion of metastatic breast cancer MDA-MB-231 cells.•STIM1 knockout induces significant transcriptional…”
Get full text

Antimicrobial effects of marine algal extracts and cyanobacterial pure compounds against five foodborne pathogens by Dussault, Dominic, Vu, Khanh Dang, Vansach, Tifanie, Horgen, F. David, Lacroix, Monique

“…•Two algal extracts (Padina sp. and Ulva sp.) showed their antibacterial activities.•Isomalyngamide A had highest antibacterial activity against B. cereus.•All…”
Get full text

Piericones A and B as Potent Antithrombotics: Nanomolar Noncompetitive Protein Disulfide Isomerase Inhibitors with an Unexpected Chemical Architecture by Zheng, Guijuan, Lv, Keyu, Wang, Hao, Huang, Lang, Feng, Yuanyuan, Gao, Biao, Sun, Yenan, Li, Yaofeng, Huang, Jiangeng, Jin, Pengfei, Xu, Xulin, Horgen, F. David, Fang, Chao, Yao, Guangmin

“…Extracellular protein disulfide isomerase (PDI) is a promising target for thrombotic-related diseases. Four potent PDI inhibitors with unprecedented chemical…”
Get full text

TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts by Zeitlmayr, Sarah, Zierler, Susanna, Staab-Weijnitz, Claudia A., Dietrich, Alexander, Geiger, Fabienne, Horgen, F. David, Gudermann, Thomas, Breit, Andreas

“…Sustained exposure of the lung to various environmental or occupational toxins may eventually lead to pulmonary fibrosis, a devastating disease with no cure…”
Get full text

Divalent cation influx and calcium homeostasis in germinal vesicle mouse oocytes by Ardestani, Goli, Mehregan, Aujan, Fleig, Andrea, Horgen, F. David, Carvacho, Ingrid, Fissore, Rafael A.

“…[Display omitted] •CaV3.2, TRPM7 and TRPV3 channels differentially mediate the influx of Ca2+ and other divalent cations in GV oocytes.•CaV3.2 and TRPM7 are…”
Get full text