Search Results - "Hordijk, Peter L."

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium by Nourshargh, Sussan, Hordijk, Peter L, Sixt, Michael

“…Key Points The shuttling of leukocytes between the blood stream and interstitial tissues involves different locomotion strategies that are governed by locally…”
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Cell-stiffness-induced mechanosignaling - a key driver of leukocyte transendothelial migration by Schaefer, Antje, Hordijk, Peter L

“…The breaching of cellular and structural barriers by migrating cells is a driving factor in development, inflammation and tumor cell metastasis. One of the…”
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Shear Stress-Induced AMP-Activated Protein Kinase Modulation in Endothelial Cells: Its Role in Metabolic Adaptions and Cardiovascular Disease by Hauger, Philipp C, Hordijk, Peter L

“…Endothelial cells (ECs) line the inner surface of all blood vessels and form a barrier that facilitates the controlled transfer of nutrients and oxygen from…”
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The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading by Majolée, Jisca, Podieh, Fabienne, Hordijk, Peter L, Kovacevic, Igor

“…Signaling by the Rho GTPase Rac1 is key to the regulation of cytoskeletal dynamics, cell spreading and adhesion. It is widely accepted that the inactive form…”
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ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia by Woodfin, Abigail, Beyrau, Martina, Voisin, Mathieu-Benoit, Ma, Bin, Whiteford, James R., Hordijk, Peter L., Hogg, Nancy, Nourshargh, Sussan

“…Intracellular adhesion molecule-1 (ICAM-1) is a transmembrane glycoprotein expressed on the cell surface of numerous cell types such as endothelial and…”
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Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases by Gils, Janine M., Zwaginga, Jaap Jan, Hordijk, Peter L.

“…Platelets, monocytes, and endothelial cells are instrumental in the development and progression of cardiovascular diseases. Inflammation, a key process…”
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Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology by Bogunovic, Natalija, Meekel, Jorn P., Micha, Dimitra, Blankensteijn, Jan D., Hordijk, Peter L., Yeung, Kak K.

“…Ruptured abdominal aortic aneurysms (AAA) are associated with overall mortality rates up to 90%. Despite extensive research, mechanisms leading to AAA…”
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Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study by Bokslag, Anouk, Franssen, Constantijn, Alma, Lisa J, Kovacevic, Igor, Kesteren, Floortje van, Teunissen, Pim W, Kamp, Otto, Ganzevoort, Wessel, Hordijk, Peter L, Groot, Christianne J M de, Paulus, Walter J

“…Systemic inflammation, endothelial dysfunction and deficient vascularization of either uterus or myocardium are mechanistic hallmarks of early-onset…”
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Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration by Schaefer, Antje, Nethe, Micha, Hordijk, Peter L

“…Post-translational modifications are used by cells to link additional information to proteins. Most modifications are subtle and concern small moieties such as…”
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The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB by Kovačević, Igor, Sakaue, Tomohisa, Majoleé, Jisca, Pronk, Manon C, Maekawa, Masashi, Geerts, Dirk, Fernandez-Borja, Mar, Higashiyama, Shigeki, Hordijk, Peter L

“…RhoGTPases control endothelial cell (EC) migration, adhesion, and barrier formation. Whereas the relevance of RhoA for endothelial barrier function is widely…”
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Stasis Promotes Erythrocyte Adhesion to von Willebrand Factor by Smeets, Michel W.J, Mourik, Marjon J, Niessen, Hans W.M, Hordijk, Peter L

“…OBJECTIVE—Venous thromboembolism is a major contributor to global disease burden. Leukocytes and platelets initiate thrombogenesis on blood stasis and initiate…”
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Actin-binding proteins differentially regulate endothelial cell stiffness, ICAM-1 function and neutrophil transmigration by Schaefer, Antje, Te Riet, Joost, Ritz, Katja, Hoogenboezem, Mark, Anthony, Eloise C, Mul, Frederik P J, de Vries, Carlie J, Daemen, Mat J, Figdor, Carl G, van Buul, Jaap D, Hordijk, Peter L

“…Chronic vascular inflammation is driven by interactions between activated leukocytes and the endothelium. Leukocyte β2-integrins bind to endothelial…”
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Dissecting the Effects of Ischemia and Reperfusion on the Coronary Microcirculation in a Rat Model of Acute Myocardial Infarction by Hollander, Maurits R, de Waard, Guus A, Konijnenberg, Lara S F, Meijer-van Putten, Rosalie M E, van den Brom, Charissa E, Paauw, Nanne, de Vries, Helga E, van de Ven, Peter M, Aman, Jurjan, Van Nieuw-Amerongen, Geerten P, Hordijk, Peter L, Niessen, Hans W M, Horrevoets, Anton J G, Van Royen, Niels

“…Microvascular injury (MVI) after coronary ischemia-reperfusion is associated with high morbidity and mortality. Both ischemia and reperfusion are involved in…”
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Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases by Hartl, Dominik, Krauss-Etschmann, Susanne, Koller, Barbara, Hordijk, Peter L, Kuijpers, Taco W, Hoffmann, Florian, Hector, Andreas, Eber, Ernst, Marcos, Veronica, Bittmann, Iris, Eickelberg, Oliver, Griese, Matthias, Roos, Dirk

“…Various inflammatory diseases are characterized by tissue infiltration of neutrophils. Chemokines recruit and activate leukocytes, but neutrophils are…”
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A New Generation of FRET Sensors for Robust Measurement of Gαi1, Gαi2 and Gαi3 Activation Kinetics in Single Cells by van Unen, Jakobus, Stumpf, Anette D, Schmid, Benedikt, Reinhard, Nathalie R, Hordijk, Peter L, Hoffmann, Carsten, Gadella, Jr, Theodorus W J, Goedhart, Joachim

“…G-protein coupled receptors (GPCRs) can activate a heterotrimeric G-protein complex with subsecond kinetics. Genetically encoded biosensors based on Förster…”
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Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro by Schaefer, Antje, van Duijn, Trynette J, Majolee, Jisca, Burridge, Keith, Hordijk, Peter L

“…Inflammation is driven by excessive transmigration (diapedesis) of leukocytes from the blood to the tissue across the endothelial cell monolayer that lines…”
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Electrostatic Forces Mediate the Specificity of RHO GTPase-GDI Interactions by Mosaddeghzadeh, Niloufar, Kazemein Jasemi, Neda S, Majolée, Jisca, Zhang, Si-Cai, Hordijk, Peter L, Dvorsky, Radovan, Ahmadian, Mohammad Reza

“…Three decades of research have documented the spatiotemporal dynamics of RHO family GTPase membrane extraction regulated by guanine nucleotide dissociation…”
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Plasminogen Activator Inhibitor-1 Controls Vascular Integrity by Regulating VE-Cadherin Trafficking by Daniel, Anna E, Timmerman, Ilse, Kovacevic, Igor, Hordijk, Peter L, Adriaanse, Luc, Paatero, Ilkka, Belting, Heinz-Georg, van Buul, Jaap D

“…Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor, is expressed and secreted by endothelial cells. Patients with PAI-1 deficiency show a…”
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Extravasation of biodegradable microspheres in the rat brain by van der Wijk, Anne-Eva, Georgakopoulou, Theodosia, Steendam, Rob, Zuidema, Johan, Hordijk, Peter L., Bakker, Erik N.T.P., van Bavel, Ed

“…Drug development for neurological diseases is greatly impeded by the presence of the blood-brain barrier (BBB). We and others previously reported on…”
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Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells by Reinhard, Nathalie R., van Helden, Suzanne F., Anthony, Eloise C., Yin, Taofei, Wu, Yi I., Goedhart, Joachim, Gadella, Theodorus W. J., Hordijk, Peter L.

“…Endothelial cells line the vasculature and are important for the regulation of blood pressure, vascular permeability, clotting and transendothelial migration…”
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