Age of onset of recurrent respiratory papillomatosis: a distribution analysis

Objective Distribution of age of onset of recurrent respiratory papillomatosis (RRP) is generally described to be bimodal, with peaks at approximately 5 years and 30 years. This assumption has never been scientifically confirmed, and authors tend to refer to an article that does not describe distrib...

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Published in:	Clinical otolaryngology Vol. 41; no. 5; pp. 448 - 453
Main Authors:	San Giorgi, M.R.M., van den Heuvel, E.R., Tjon Pian Gi, R.E.A., Brunings, J.W., Chirila, M., Friedrich, G., Golusinski, W., Graupp, M., Horcasitas Pous, R.A., Ilmarinen, T., Jackowska, J., Koelmel, J.C., Ferran Vilà, F., Weichbold, V., Wierzbicka, M., Dikkers, F.G.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-10-2016 Wiley Subscription Services, Inc
Subjects:	Adolescent Adult Age Age of Onset Bayes Theorem Child Cross-Sectional Studies Europe - epidemiology Female Humans Male Middle Aged Papillomavirus Infections - epidemiology Respiratory Tract Infections - epidemiology
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Summary:	Objective Distribution of age of onset of recurrent respiratory papillomatosis (RRP) is generally described to be bimodal, with peaks at approximately 5 years and 30 years. This assumption has never been scientifically confirmed, and authors tend to refer to an article that does not describe distribution. Knowledge of the distribution of age of onset is important for virological and epidemiological comprehension. The objective of this study was to determine the distribution of age of onset of RRP in a large international sample. Design Cross‐sectional distribution analysis. Participants Laryngologists from 12 European hospitals provided information on date of birth and date of onset of all their RRP patients treated between 1998 and 2012. Centers that exclusively treated either patients with juvenile onset RRP or patients with adult onset RRP, or were less accessible for one of these groups, were excluded to prevent skewness. Main outcome measures A mixture model was implemented to describe distribution of age of onset. The best fitting model was selected using the Bayesian information criterion. Results Six hundred and thirty‐nine patients were included in the analysis. Age of onset was described by a three component mixture distribution with lognormally distributed components. Recurrent respiratory papillomatosis starts at three median ages 7, 35 and 64 years. Conclusions Distribution of age of onset of RRP shows three peaks. In addition to the already adopted idea of age peaks at paediatric and adult age, there is an additional peak around the age of 64.
Bibliography:	ArticleID:COA12565 istex:C3775DCDC251A10A989E3C0DE7FEC617426751A1 ark:/67375/WNG-284XWBC1-V ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1749-4478 1749-4486
DOI:	10.1111/coa.12565