Search Results - "Horak, Eva M."

A single treatment of yttrium-90-labeled CHX-A-c6.5 diabody inhibits the growth of established human tumor xenografts in immunodeficient mice by ADAMS, Gregory P, SHALLER, Calvin C, DADACHOVA, Ekaterina, SIMMONS, Heidi H, HORAK, Eva M, TESFAYE, Abohawariat, KLEIN-SZANTO, Andres J. P, MARKS, James D, BRECHBIEL, Martin W, WEINER, Louis M

“…Antitumor diabody molecules are noncovalent single-chain Fv dimers that recapitulate the divalent binding properties of native IgG antibodies. Diabodies are…”
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Increasing the Affinity for Tumor Antigen Enhances Bispecific Antibody Cytotoxicity by McCall, Adrian M, Shahied, Lillian, Amoroso, Anne R, Horak, Eva M, Simmons, Heidi H, Nielson, Ulrick, Adams, Gregory P, Schier, Robert, Marks, James D, Weiner, Louis M

“…We tested the hypothesis that bispecific Abs (Bsab) with increased binding affinity for tumor Ags augment retargeted antitumor cytotoxicity. We report that an…”
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High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules by ADAMS, Gregory P, SCHIER, Robert, MCCALL, Adrian M, SIMMONS, Heidi H, HORAK, Eva M, ALPAUGH, R. Katherine, MARKS, James D, WEINER, Louis M

“…Antitumor monoclonal antibodies must bind to tumor antigens with high affinity to achieve durable tumor retention. This has spurred efforts to generate high…”
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Pillars article: the CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. 1994 by Veillette, André, Bookman, Michael A, Horak, Eva M, Bolen, Joseph B

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Signal Transduction through the CD4 Receptor Involves the Activation of the Internal Membrane Tyrosine-Protein Kinase p56(lck) by Veillette, Andre, Bookman, Michael A, Horak, Eva M, Samelson, Lawrence E, Bolen, Joseph B

“…The CD4 T-cell surface antigen is an integral membrane glycoprotein of relative molecular mass 55,000 which binds class II major histocompatibility complex…”
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Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck by VEILLETTE, A, BOOKMAN, M. A, HORAK, E. M, SAMELSON, L. E, BOLEN, J B

“…The CD4 T-cell surface antigen is an integral membrane glycoprotein of relative molecular mass 55,000 which binds class II major histocompatibility complex…”
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Effects of the tyrosine‐kinase inhibitor geldanamycin on ligand‐induced HER‐2/NEU activation, receptor expression and proliferation of HER‐2‐positive malignant cell lines by Hartmann, Frank, Horak, Eva M., Cho, Cheryl, Lupu, Ruth, Bolen, Joseph B., Stetler‐Stevenson, Mary A., Pfreundschuh, Michael, Waldmann, Thomas A., Horak, Ivan D.

“…Geldanamycin belongs to the family of benzoquinoid ansamycin tyrosine‐kinase inhibitors. We have examined its effects on Her‐2/neu kinase activity, protein…”
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No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120 by Horak, Ivan D, Popovic, Mikulas, Horak, Eva M, Lucas, Philip J, Gress, Ronald E, June, Carl H, Bolen, Joseph B

“…The T lymphocyte surface protein CD4 is an integral membrane glycoprotein noncovalently associated with the tyrosine protein kinase p56lck. In normal T cells,…”
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Pillars Article: The CD4 and CD8 T Cell Surface Antigens are Associated with the Internal Membrane Tyrosine-Protein Kinase p56lck. Cell 1994. 77: 301-308 by Veillette, Andre, Bookman, Michael A, Horak, Eva M, Bolen, Joseph B

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck by Veillette, A, Bookman, M A, Horak, E M, Bolen, J B

“…The CD4 and CD8 T cell antigens are thought to transduce an independent signal during the process of T cell activation. We report our evaluation of the…”
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Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56 lck by Veillette, André, Bookman, Michael A, Horak, Eva M, Samelson, Lawrence E, Bolen, Joseph B

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T-Lymphocyte Interleukin 2-Dependent Tyrosine Protein Kinase Signal Transduction Involves the Activation of p56lck by Horak, Ivan D., Gress, Ronald E., Lucas, Phillip J., Horak, Eva M., Waldmann, Thomas A., Bolen, Joseph B.

“…Addition of interleukin 2 (IL-2) to IL-2-dependent T cells results in tyrosine protein kinase signal transduction events even though the IL-2 receptor α and β…”
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Alterations of the Lymphocyte-Specific Protein Tyrosine Kinase (p56 lck ) during T-Cell Activation by Veillette, André, Horak, Ivan D., Horak, Eva M., Bookman, Michael A., Bolen, Joseph B.

“…The lymphocyte-specific tyrosine protein kinase p56 lck is abundantly expressed in L3T4 + (CD4 + ) and Lyt-2 + (CD8 + ) T-lymphocytes, where it is…”
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