Search Results - "Horai, Y."

Activation of Toll‐like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients by Shimizu, T., Nakamura, H., Takatani, A., Umeda, M., Horai, Y., Kurushima, S., Michitsuji, T., Nakashima, Y., Kawakami, A.

“…Summary The aim of this study was to determine the expressions of Toll‐like receptors (TLRs) 7–9 and type I interferon (IFN) signal in labial salivary glands…”
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IL‐15 is a biomarker involved in the development of rapidly progressive interstitial lung disease complicated with polymyositis/dermatomyositis by Shimizu, T., Koga, T., Furukawa, K., Horai, Y., Fujikawa, K., Okada, A., Okamoto, M., Endo, Y., Tsuji, S., Takatani, A., Umeda, M., Fukui, S., Sumiyoshi, R., Kawashiri, S.‐y., Iwamoto, N., Igawa, T., Ichinose, K., Tamai, M., Sakamoto, N., Nakamura, H., Origuchi, T., Mukae, H., Kuwana, M., Kawakami, A.

“…Background Polymyositis/dermatomyositis (PM/DM) is an autoimmune disease that is sometimes complicated with rapidly progressive interstitial lung disease…”
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Review article: cytochrome P450 and the metabolism of proton pump inhibitors — emphasis on rabeprazole by Ishizaki, T, Horai, Y

“…The proton pump inhibitors rabeprazole, omeprazole, lansoprazole, and pantoprazole undergo an extensive hepatic biotransformation. In the liver, they are…”
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Factors predictive of long-term mortality in lupus nephritis: a multicenter retrospective study of a Japanese cohort by Ichinose, K, Kitamura, M, Sato, S, Fujikawa, K, Horai, Y, Matsuoka, N, Tsuboi, M, Nonaka, F, Shimizu, T, Fukui, S, Umeda, M, Koga, T, Kawashiri, S, Iwamoto, N, Tamai, M, Nakamura, H, Origuchi, T, Nishino, T, Kawakami, A

“…Background Lupus nephritis (LN) is a major determinant of mortality in systemic lupus erythematosus (SLE). Here we evaluated the association between complete…”
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Ultrasonography as an additional item in the American College of Rheumatology classification of Sjögren's syndrome by Takagi, Yukinori, Sumi, Misa, Nakamura, Hideki, Iwamoto, Naoki, Horai, Yoshiro, Kawakami, Atsushi, Nakamura, Takashi

“…In this study we evaluated US as an additional classification item in the ACR classification of SS. Of 581 patients classified as either SS (n = 364) or non-SS…”
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The efficacy of adjunct tacrolimus treatment in pregnancy outcomes in patients with systemic lupus erythematosus by Ichinose, K, Sato, S, Kitajima, Y, Horai, Y, Fujikawa, K, Umeda, M, Fukui, S, Nishino, A, Koga, T, Kawashiri, S Y, Iwamoto, N, Tamai, M, Nakamura, H, Origuchi, T, Yasuhi, I, Masuzaki, H, Kawakami, A

“…Systemic lupus erythematosus (SLE) involves multiple organ systems and primarily affects women during their reproductive years. Pregnancy in a woman with SLE…”
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Eternacept for the treatment of patients with rheumatoid arthritis and concurrent interstitial lung disease by Horai, Y., Miyamura, T., Shimada, K., Takahama, S., Minami, R., Yamamoto, M., Suematsu, E.

“…Summary What is known and Objective:  Tumour necrosis factor‐α (TNF‐α)‐blocking agents are increasingly used in the management of refractory rheumatoid…”
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Pharmacodynamic effects and kinetic disposition of rabeprazole in relation to CYP2C19 genotypes by Horai, Y., Kimura, M., Furuie, H., Matsuguma, K., Irie, S., Koga, Y., Nagahama, T., Murakami, M., Matsui, T., Yao, T., Urae, A., Ishizaki, T.

“…Background: S‐mephenytoin 4’‐hydroxylase (CYP2C19) catalyses the metabolism of rabeprazole to some extent. Based on the metabolic and pharmacokinetic…”
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The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM by KOGA, Tomohiro, FUJIKAWA, Keita, YAMASAKI, Satoshi, NAKAMURA, Hideki, ORIGUCHI, Tomoki, HAMAGUCHI, Yasuhito, FUJIMOTO, Manabu, ISHIMATSU, Yuji, MUKAE, Hiroshi, KUWANA, Masataka, KOHNO, Shigeru, EGUCHI, Katsumi, HORAI, Yoshiro, AOYAGI, Kiyoshi, KAWAKAMI, Atsushi, OKADA, Akitomo, KAWASHIRI, Shin-Ya, IWAMOTO, Naoki, SUZUKI, Takahisa, NAKASHIMA, Yoshikazu, TAMAI, Mami, ARIMA, Kazuhiko

“…Interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD), is a major poor prognostic factor in patients with DM. We investigated the…”
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Comparative pharmacology of the ketamine isomers. Studies in volunteers by White, P F, Schüttler, J, Shafer, A, Stanski, D R, Horai, Y, Trevor, A J

“…The clinical and electroencephalographic (EEG) effects of the individual ketamine isomers were compared with the racemic mixture in five volunteers who…”
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Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion by Kawashiri, Shin-ya, Suzuki, Takahisa, Nakashima, Yoshikazu, Horai, Yoshiro, Okada, Akitomo, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Arima, Kazuhiko, Nakamura, Hideki, Origuchi, Tomoki, Uetani, Masataka, Aoyagi, Kiyoshi, Eguchi, Katsumi, Kawakami, Atsushi

“…Objective. The aim of this study was to investigate the characteristics of power Doppler (PD) subclinical synovitis in patients with RA who achieve clinical…”
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Rheumatoid arthritis patients with low baseline Health Assessment Questionnaire scores have a risk of functional disability progression: a post hoc analysis of a nationwide longitudinal cohort in Japan by Sumiyoshi, Remi, Hidaka, Toshihiko, Koga, Tomohiro, Okada, Akitomo, Fukuda, Takaaki, Ishii, Tomonori, Ueki, Yukitaka, Kodera, Takao, Nakashima, Munetoshi, Takahashi, Yuichi, Honda, Seiyo, Horai, Yoshiro, Watanabe, Ryu, Okuno, Hiroshi, Aramaki, Toshiyuki, Izumiyama, Tomomasa, Takai, Osamu, Miyashita, Taiichiro, Kawashiri, Shin-Ya, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Eguchi, Katsumi, Kawakami, Atsushi

“…To determine prognostic factors for the Health Assessment Questionnaire-Disability Index (HAQ-DI) progression in patients with rheumatoid arthritis (RA) in…”
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N‐acetylation polymorphism of dapsone in a Japanese population by Horai, Y, Ishizaki, T

“…1. The N‐acetylation of dapsone (DDS) was studied in 182 unrelated healthy Japanese subjects. The frequency of slow acetylators determined using the plasma…”
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Correlations among the metabolic ratios of three test probes (metoprolol, debrisoquine and sparteine) for genetically determined oxidation polymorphism in a Japanese population by Horai, Y, Taga, J, Ishizaki, T, Ishikawa, K

“…The study was aimed at defining the relationships among the oxidative capacities for three prototype drugs, metoprolol, debrisoquine and sparteine, used for…”
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Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis by Kawashiri, Shin-ya, Suzuki, Takahisa, Nakashima, Yoshikazu, Horai, Yoshiro, Okada, Akitomo, Nishino, Ayako, Iwamoto, Naoki, Ichinose, Kunihiro, Arima, Kazuhiko, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Uetani, Masataka, Aoyagi, Kiyoshi, Eguchi, Katsumi, Kawakami, Atsushi

“…The aim of this study was to explore whether assessment of synovial inflammation by ultrasonography correlates with MRI-proven osteitis in patients with RA…”
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Detection of human T lymphotropic virus type-I bZIP factor and tax in the salivary glands of Sjögren's syndrome patients by Nakamura, Hideki, Hasegawa, Hiroo, Sasaki, Daisuke, Takatani, Ayuko, Shimizu, Toshimasa, Kurushima, Shota, Horai, Yoshiro, Nakashima, Yoshikazu, Nakamura, Tatsufumi, Fukuoka, Junya, Kawakami, Atsushi

“…To detect HTLV-I bZIP factor (HBZ), tax and relevant molecules in labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS). The expressions of…”
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Genetically determined N-acetylation and oxidation capacities in Japanese patients with non-occupational urinary bladder cancer by HORAI, Y, FUJITA, K, ISHIZAKI, T

“…Genetically determined polymorphisms of N-acetylation and oxidative capacity have been studied using dapsone and metoprolol in 51 Japanese patients with…”
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Evidence for polymorphic oxidation of sparteine in Japanese subjects by Ishizaki, T, Eichelbaum, M, Horai, Y, Hashimoto, K, Chiba, K, Dengler, HJ

“…The metabolism of sparteine which exhibits a genetic polymorphism in Caucasians was studied in 84 unrelated Japanese subjects. In contrast to a recent study…”
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Rapid improvement of Clinical Disease Activity Index (CDAI) at 3 months predicts a preferable CDAI outcome at 1 year in active rheumatoid arthritis patients treated with tocilizumab: results from an observational investigation of daily clinical practice by Kawashiri, Shin-Ya, Nishino, Ayako, Suzuki, Takahisa, Nakashima, Yoshikazu, Horai, Yoshiro, Ueki, Yukitaka, Aramaki, Toshiyuki, Fujikawa, Keita, Nakashima, Munetoshi, Okada, Akitomo, Migita, Kiyoshi, Mizokami, Akinari, Matsuoka, Naoki, Mine, Masanobu, Sakito, Soko, Iwamoto, Naoki, Ichinose, Kunihiro, Tamai, Mami, Nakamura, Hideki, Origuchi, Tomoki, Aoyagi, Kiyoshi, Eguchi, Katsumi, Kawakami, Atsushi

“…To investigate whether the Clinical Disease Activity Index (CDAI) at three months predicts a preferable CDAI outcome at one year in patients with active…”
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Comorbid case of IgG4-related disease and primary Sjögren's syndrome by Nakashima, Yoshikazu, Nakamura, Hideki, Horai, Yoshiro, Hayashi, Tomayoshi, Takagi, Yukinori, Nakamura, Takashi, Kawakami, Atsushi

“…Abstract A 63-year-old man with enlargement of the bilateral submandibular glands visited with elevated serum IgG4. A biopsy specimen showed plasma cell…”
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