Search Results - "Horace H. Loh"

Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids by Liu, Xian-Yu, Liu, Zhong-Chun, Sun, Yan-Gang, Ross, Michael, Kim, Seungil, Tsai, Feng-Fang, Li, Qi-Fang, Jeffry, Joseph, Kim, Ji-Young, Loh, Horace H., Chen, Zhou-Feng

“…Spinal opioid-induced itch, a prevalent side effect of pain management, has been proposed to result from pain inhibition. We now report that the μ-opioid…”
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Characterizing the seizure onset zone and epileptic network using EEG-fMRI in a rat seizure model by Wang, Junling, Jing, Bin, Liu, Ru, Li, Donghong, Wang, Wei, Wang, Jiaoyang, Lei, Jianfeng, Xing, Yue, Yan, Jiaqing, Loh, Horace H., Lu, Guangming, Yang, Xiaofeng

“…•EEG-fMRI could delineate the seizure onset zone in a rat model of focal seizure.•There was a high correlation of the BOLD responses with the SOZ.•There was a…”
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Morphine Modulates Adult Neurogenesis and Contextual Memory by Impeding the Maturation of Neural Progenitors by Zhang, Yue, Xu, Chi, Zheng, Hui, Loh, Horace H, Law, Ping-Yee

“…The regulation of adult neurogenesis by opiates has been implicated in modulating different addiction cycles. At which neurogenesis stage opiates exert their…”
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Transcriptional and Epigenetic Regulation of Opioid Receptor Genes: Present and Future by WEI, Li-Na, LOH, Horace H

“…Three opioid receptors (ORs) are known: μ opioid receptors (MORs), δ opioid receptors (DORs), and κ opioid receptors (KORs). Each is encoded by a distinct…”
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Effect of Opioid on Adult Hippocampal Neurogenesis by Zhang, Yue, Law, Ping-Yee, Loh, Horace H.

“…During the past decade, the study of the mechanisms and functional implications of adult neurogenesis has significantly progressed. Many studies focus on the…”
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Localization of the Epileptogenic Zone by Multimodal Neuroimaging and High-Frequency Oscillation by Li, Xiaonan, Yu, Tao, Ren, Zhiwei, Wang, Xueyuan, Yan, Jiaqing, Chen, Xin, Yan, Xiaoming, Wang, Wei, Xing, Yue, Zhang, Xianchang, Zhang, Herui, Loh, Horace H., Zhang, Guojun, Yang, Xiaofeng

“…Accurate localization of the epileptogenic zone (EZ) is a key factor to obtain good surgical outcome for refractory epilepsy patients. However, no technique,…”
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Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway by Liang, Lining, Chen, Jinlong, Li, Yuan, Lai, Xiaowei, Sun, Hao, Li, Changpeng, Zhang, Mengdan, Yang, Tingting, Meng, Fei, Law, Ping-Yee, Loh, Horace H., Zheng, Hui

“…Normally, opioids function in a receptor-dependent manner. They bind to opioid receptors, activate or inhibit receptor activation, and subsequently modulate…”
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Imbalance between the function of Na+-K+-2Cl and K+-Cl impairs Cl– homeostasis in human focal cortical dysplasia by Liu, Ru, Xing, Yue, Zhang, Herui, Wang, Junling, Lai, Huanling, Cheng, Lipeng, Li, Donghong, Yu, Tao, Yan, Xiaoming, Xu, Cuiping, Piao, Yueshan, Zeng, Linghui, Loh, Horace H., Zhang, Guojun, Yang, Xiaofeng

“…Objective: Altered expression patterns of Na+-K+-2Cl- (NKCC1) and K+-Cl- (KCC2) co-transporters have been implicated in the pathogenesis of epilepsy. Here, we…”
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Poly(C)-binding proteins as transcriptional regulators of gene expression by Choi, Hack Sun, Hwang, Cheol Kyu, Song, Kyu Young, Law, Ping-Yee, Wei, Li-Na, Loh, Horace H.

“…Poly(C)-binding proteins (PCBPs) are generally known as RNA-binding proteins that interact in a sequence-specific fashion with single-stranded poly(C). They…”
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Agonist-selective signaling is determined by the receptor location within the membrane domains by Zheng, Hui, Chu, Ji, Qiu, Yu, Loh, Horace H, Law, Ping-Yee

“…The basis for agonist-selective signaling was investigated by using the μ-opioid receptor (MOR) as a model. In the absence of agonist, MOR located within the…”
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Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation by Sun, Jiaqi, Yang, Junzheng, Miao, Xiaoli, Loh, Horace H., Pei, Duanqing, Zheng, Hui

“…Background Epigenetic modifications, namely non-coding RNAs, DNA methylation, and histone modifications such as methylation, phosphorylation, acetylation,…”
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Agonist‐selective signaling of G protein‐coupled receptor: Mechanisms and implications by Zheng, Hui, Loh, Horace H., Law, Ping‐Yee

“…Agonist‐selective signaling or ligand‐biased signaling of G protein‐coupled receptor (GPCR) has become the focus of an increasing number of laboratories. The…”
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Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans by Zheng, Hui, Zou, Haibo, Liu, Xiaopeng, Chu, Ji, Zhou, Yali, Loh, Horace H., Law, Ping-Yee

“…Cholesterol regulates the signaling of µ-opioid receptor in cell models, but it has not been demonstrated in mice or humans. Whether cholesterol regulates the…”
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Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc by Flaisher-Grinberg, Shlomit, Persaud, Shawna D, Loh, Horace H, Wei, Li-Na

“…Exposure to stress is associated with adverse emotional and behavioral responses. Whereas the κ-opioid receptor (KOR) system is known to mediate some of the…”
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Molecular mechanisms and regulation of opioid receptor signaling by Law, P Y, Wong, Y H, Loh, H H

“…Cloning of multiple opioid receptors has presented opportunities to investigate the mechanisms of multiple opioid receptor signaling and the regulation of…”
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Axonal mRNA transport and localized translational regulation of κ-opioid receptor in primary neurons of dorsal root ganglia by Bi, Jing, Tsai, Nien-Pei, Lin, Ya-Ping, Loh, Horace H, Wei, Li-Na

“…κ-opioid receptor (KOR) is detected pre- and postsynaptically, but the subcellular localization, translation, and regulation of kor mRNA in presynaptic…”
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Mu-Opioid Receptors Modulate the Stability of Dendritic Spines by Liao, Dezhi, Lin, Hang, Law, Ping Yee, Loh, Horace H., Huganir, Richard L.

“…Opioids classically regulate the excitability of neurons by suppressing synaptic GABA release from inhibitory neurons. Here, we report a role for opioids in…”
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Copb1-Facilitated Axonal Transport and Translation of κ Opioid-Receptor mRNA by Bi, Jing, Tsai, Nien-Pei, Lu, Hsin-Yi, Loh, Horace H., Wei, Li-Na

“…mRNA of κ opioid receptor (KOR) can be transported to nerve fibers, including axons of dorsal root ganglia (DRG), and can be locally translated. Yeast…”
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Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization by Zhao, Hui, Loh, Horace H, Law, P Y

“…Long-term opioid agonist treatment results in adenylyl cyclase superactivation. A recent "RAVE" theory implicates a direct correlation between the ability of…”
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Non-Coding RNAs Regulating Morphine Function: With Emphasis on the In vivo and In vitro Functions of miR-190 by Zheng, Hui, Law, Ping-Yee, Loh, Horace H

“…Non-coding RNAs (ncRNAs), especially microRNAs, are reported to be involved in a variety of biological processes, including several processes related to drug…”
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