Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men

Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men

Abstract Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined...

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Bibliographic Details
Published in:Metabolism, clinical and experimental Vol. 59; no. 12; pp. 1742 - 1751
Main Authors: Nakata, Katsumi, Choo, Jina, Hopson, Michael J.S, Ueshima, Hirotsugu, Curb, J. David, Shin, Chol, Evans, Rhobert W, Kadowaki, Takashi, Otake, Teruo, Kadota, Aya, Kadowaki, Syaka, Miura, Katsuyuki, El-Saed, Aiman, Edmundowicz, Daniel, Sutton-Tyrrell, Kim, Kuller, Lewis H, Sekikawa, Akira
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-12-2010
Elsevier
Subjects:
Abdomen
Adult
Biological and medical sciences
Body Mass Index
Endocrinology & Metabolism
European Continental Ancestry Group
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Humans
Japan
Lipoproteins - blood
Lipoproteins - classification
Magnetic Resonance Spectroscopy
Male
Middle Aged
United States
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Waist Circumference
United States
North America
America
Japan
Human
Waist circumference
Middle age
Association
Sagittal abdominal diameter
Anthropometry
Corporal biometry
Lipoprotein
Waist hip ratio
Japanese
Endocrinology
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Summary:Abstract Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined relative associations of SAD vs WC with lipoprotein subfractions for US white and Japanese men, concurrently examining the associations of VAT vs subcutaneous adipose tissue with lipoprotein subfractions. A population-based sample of 260 white and 282 Japanese men aged 40 to 49 years was examined for VAT and subcutaneous adipose tissue by computed tomography; SAD and WC by a portable sliding-beam caliper and a measuring tape, respectively; and lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Both SAD and WC were significantly and positively associated with large very low-density lipoprotein and total and small low-density lipoprotein particle concentrations, and inversely associated with large high-density lipoprotein particle concentration for both white and Japanese men. In body mass index–adjusted regression models, the significant associations of SAD remained for both white and Japanese men, whereas those of WC became nonsignificant for white men. When SAD and WC were simultaneously included into the body mass index–adjusted models, the associations of SAD remained significant and statistically stronger than those of WC for both white and Japanese men. Furthermore, the pattern of the associations of SAD with those lipoprotein subfractions was comparable to that of the associations of VAT. Sagittal abdominal diameter was comparable to VAT and stronger than WC in the associations with atherogenic lipoprotein subfractions for middle-aged, nondiabetic, white and Japanese men.
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ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2010.04.019