Search Results - "Hopper, John L."

Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers by Kuchenbaecker, Karoline B, Hopper, John L, Barnes, Daniel R, Phillips, Kelly-Anne, Mooij, Thea M, Roos-Blom, Marie-José, Jervis, Sarah, van Leeuwen, Flora E, Milne, Roger L, Andrieu, Nadine, Goldgar, David E, Terry, Mary Beth, Rookus, Matti A, Easton, Douglas F, Antoniou, Antonis C, McGuffog, Lesley, Evans, D. Gareth, Barrowdale, Daniel, Frost, Debra, Adlard, Julian, Ong, Kai-ren, Izatt, Louise, Tischkowitz, Marc, Eeles, Ros, Davidson, Rosemarie, Hodgson, Shirley, Ellis, Steve, Nogues, Catherine, Lasset, Christine, Stoppa-Lyonnet, Dominique, Fricker, Jean-Pierre, Faivre, Laurence, Berthet, Pascaline, Hooning, Maartje J, van der Kolk, Lizet E, Kets, Carolien M, Adank, Muriel A, John, Esther M, Chung, Wendy K, Andrulis, Irene L, Southey, Melissa, Daly, Mary B, Buys, Saundra S, Osorio, Ana, Engel, Christoph, Kast, Karin, Schmutzler, Rita K, Caldes, Trinidad, Jakubowska, Anna, Simard, Jacques, Friedlander, Michael L, McLachlan, Sue-Anne, Machackova, Eva, Foretova, Lenka, Tan, Yen Y, Singer, Christian F, Olah, Edith, Gerdes, Anne-Marie, Arver, Brita, Olsson, Håkan

“…IMPORTANCE: The clinical management of BRCA1 and BRCA2 mutation carriers requires accurate, prospective cancer risk estimates. OBJECTIVES: To estimate…”
Get full text

Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women by Manchanda, Ranjit, Patel, Shreeya, Gordeev, Vladimir S, Antoniou, Antonis C, Smith, Shantel, Lee, Andrew, Hopper, John L, MacInnis, Robert J, Turnbull, Clare, Ramus, Susan J, Gayther, Simon A, Pharoah, Paul D P, Menon, Usha, Jacobs, Ian, Legood, Rosa

“…The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We…”
Get full text

Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors by Jeon, Jihyoun, Du, Mengmeng, Schoen, Robert E., Hoffmeister, Michael, Newcomb, Polly A., Berndt, Sonja I., Caan, Bette, Campbell, Peter T., Chan, Andrew T., Chang-Claude, Jenny, Giles, Graham G., Gong, Jian, Harrison, Tabitha A., Huyghe, Jeroen R., Jacobs, Eric J., Li, Li, Lin, Yi, Le Marchand, Loïc, Potter, John D., Qu, Conghui, Bien, Stephanie A., Zubair, Niha, Macinnis, Robert J., Buchanan, Daniel D., Hopper, John L., Cao, Yin, Nishihara, Reiko, Rennert, Gad, Slattery, Martha L., Thomas, Duncan C., Woods, Michael O., Prentice, Ross L., Gruber, Stephen B., Zheng, Yingye, Brenner, Hermann, Hayes, Richard B., White, Emily, Peters, Ulrike, Hsu, Li

“…Guidelines for initiating colorectal cancer (CRC) screening are based on family history but do not consider lifestyle, environmental, or genetic risk factors…”
Get full text

Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer by Win, Aung Ko, Jenkins, Mark A, Dowty, James G, Antoniou, Antonis C, Lee, Andrew, Giles, Graham G, Buchanan, Daniel D, Clendenning, Mark, Rosty, Christophe, Ahnen, Dennis J, Thibodeau, Stephen N, Casey, Graham, Gallinger, Steven, Le Marchand, Loïc, Haile, Robert W, Potter, John D, Zheng, Yingye, Lindor, Noralane M, Newcomb, Polly A, Hopper, John L, MacInnis, Robert J

“…Although high-risk mutations in identified major susceptibility genes (DNA mismatch repair genes and ) account for some familial aggregation of colorectal…”
Get full text

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies by Dugué, Pierre‐Antoine, Bassett, Julie K., Joo, JiHoon E., Jung, Chol‐Hee, Ming Wong, Ee, Moreno‐Betancur, Margarita, Schmidt, Daniel, Makalic, Enes, Li, Shuai, Severi, Gianluca, Hodge, Allison M., Buchanan, Daniel D., English, Dallas R., Hopper, John L., Southey, Melissa C., Giles, Graham G., Milne, Roger L.

“…The association between aging and cancer is complex. Recent studies have developed measures of biological aging based on DNA methylation and called them “age…”
Get full text

Familial aggregation of esophageal cancer by Li, Shuai, Hopper, John L.

“…The study has several strengths including its large sample size of 33,008 participants with a high proportion of family history (15.2% having an affected…”
Get full text

Residential surrounding greenness and DNA methylation: An epigenome-wide association study by Xu, Rongbin, Li, Shuai, Li, Shanshan, Wong, Ee Ming, Southey, Melissa C., Hopper, John L., Abramson, Michael J., Guo, Yuming

“…[Display omitted] •Greenspace was associated with DNA methylation of multiple human genome loci.•Those loci are mapped to many genes related to many human…”
Get full text

Mammographic Density Phenotypes and Risk of Breast Cancer: A Meta-analysis by PETTERSSON, Andreas, GRAFF, Rebecca E, CZENE, Kamila, ERIKSSON, Louise, HALL, Per, HARTMAN, Mikael, WARREN, Ruth M. L, HISLOP, Greg, CHIARELLI, Anna M, HOPPER, John L, KRISHNAN, Kavitha, JINGMEI LI, URSIN, Giske, QING LI, PAGANO, Ian, ROSNER, Bernard A, CHIA SIONG WONG, SCOTT, Christopher, STONE, Jennifer, MASKARINEC, Gertraud, BOYD, Norman F, VAN GILS, Carla H, TAMIMI, Rulla M, SANTOS SILVA, Isabel Dos, MCCORMACK, Valerie, BAGLIETTO, Laura, VACHON, Celine, BAKKER, Marije F, GILES, Graham G, KEE SENG CHIA

“…Fibroglandular breast tissue appears dense on mammogram, whereas fat appears nondense. It is unclear whether absolute or percentage dense area more strongly…”
Get full text

Wildfire-related PM2.5 and DNA methylation: An Australian twin and family study by Xu, Rongbin, Li, Shanshan, Wu, Yao, Yue, Xu, Wong, Ee Ming, Southey, Melissa C., Hopper, John L., Abramson, Michael J., Li, Shuai, Guo, Yuming

“…[Display omitted] •Wildfire PM2.5 was associated with DNA methylation of many human genome loci.•Those loci were mapped to 47 genes related to many human…”
Get full text

Ability of known colorectal cancer susceptibility SNPs to predict colorectal cancer risk: A cohort study within the UK Biobank by Gafni, Aviv, Dite, Gillian S, Spaeth Tuff, Erika, Allman, Richard, Hopper, John L

“…Colorectal cancer risk stratification is crucial to improve screening and risk-reducing recommendations, and consequently do better than a one-size-fits-all…”
Get full text

A streamlined model for use in clinical breast cancer risk assessment maintains predictive power and is further improved with inclusion of a polygenic risk score by Allman, Richard, Spaeth, Erika, Lai, John, Gross, Susan J, Hopper, John L

“…Five-year absolute breast cancer risk prediction models are required to comply with national guidelines regarding risk reduction regimens. Models including the…”
Get full text

Polygenic risk scores for cardiovascular diseases and type 2 diabetes by Wong, Chi Kuen, Makalic, Enes, Dite, Gillian S, Whiting, Lawrence, Murphy, Nicholas M, Hopper, John L, Allman, Richard

“…Polygenic risk scores (PRSs) are a promising approach to accurately predict an individual's risk of developing disease. The area under the receiver operating…”
Get full text

Heritable DNA methylation marks associated with susceptibility to breast cancer by Joo, Jihoon E., Dowty, James G., Milne, Roger L., Wong, Ee Ming, Dugué, Pierre-Antoine, English, Dallas, Hopper, John L., Goldgar, David E., Giles, Graham G., Southey, Melissa C.

“…Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable…”
Get full text

Epigenetic supersimilarity of monozygotic twin pairs by Van Baak, Timothy E, Coarfa, Cristian, Dugué, Pierre-Antoine, Fiorito, Giovanni, Laritsky, Eleonora, Baker, Maria S, Kessler, Noah J, Dong, Jianrong, Duryea, Jack D, Silver, Matt J, Saffari, Ayden, Prentice, Andrew M, Moore, Sophie E, Ghantous, Akram, Routledge, Michael N, Gong, Yun Yun, Herceg, Zdenko, Vineis, Paolo, Severi, Gianluca, Hopper, John L, Southey, Melissa C, Giles, Graham G, Milne, Roger L, Waterland, Robert A

“…Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The phenotypic and epigenetic…”
Get full text

Colorectal and Other Cancer Risks for Carriers and Noncarriers From Families With a DNA Mismatch Repair Gene Mutation: A Prospective Cohort Study by AUNG KO WIN, YOUNG, Joanne P, MACRAE, Finlay A, GOLDBLATT, Jack, SOUTHEY, Melissa C, ARNOLD, Julie, THIBODEAU, Stephen N, GUNAWARDENA, Shanaka R, BAPAT, Bharati, BARON, John A, CASEY, Graham, GALLINGER, Steven, LINDOR, Noralane M, MARCHAND, Loïc Le, NEWCOMB, Polly A, HAILE, Robert W, HOPPER, John L, JENKINS, Mark A, TUCKER, Katherine M, AHNEN, Dennis J, YOUNG, Graeme P, BUCHANAN, Daniel D, CLENDENNING, Mark, GILES, Graham G, WINSHIP, Ingrid

“…To determine whether cancer risks for carriers and noncarriers from families with a mismatch repair (MMR) gene mutation are increased above the risks of the…”
Get full text

Identification of IL6R and chromosome 11q13.5 as risk loci for asthma by Ferreira, Manuel AR, Dr, Matheson, Melanie C, PhD, Duffy, David L, PhD, Marks, Guy B, Prof, Hui, Jennie, PhD, Le Souëf, Peter, Prof, Danoy, Patrick, PhD, Baltic, Svetlana, PhD, Nyholt, Dale R, PhD, Jenkins, Mark, PhD, Hayden, Catherine, PhD, Willemsen, Gonneke, PhD, Ang, Wei, MSc, Kuokkanen, Mikko, PhD, Beilby, John, PhD, Cheah, Faang, BSc, de Geus, Eco JC, PhD, Ramasamy, Adaikalavan, DPhil, Vedantam, Sailaja, PhD, Salomaa, Veikko, PhD, Madden, Pamela A, PhD, Heath, Andrew C, Prof, Hopper, John L, Prof, Visscher, Peter M, PhD, Musk, Bill, Prof, Leeder, Stephen R, Prof, Jarvelin, Marjo-Riitta, Prof, Pennell, Craig, PhD, Boomsma, Dorret I, Prof, Hirschhorn, Joel N, Prof, Walters, Haydn, Prof, Martin, Nicholas G, Prof, James, Alan, FRACP, Jones, Graham, PhD, Abramson, Michael J, Prof, Robertson, Colin F, FRACP, Dharmage, Shyamali C, PhD, Brown, Matthew A, Prof, Montgomery, Grant W, PhD, Thompson, Philip J, Prof

“…Summary Background We aimed to identify novel genetic variants affecting asthma risk, since these might provide novel insights into molecular mechanisms…”
Get full text

Epigenome-wide association study of short-term temperature fluctuations based on within-sibship analyses in Australian females by Wu, Yao, Xu, Rongbin, Li, Shanshan, Ming Wong, Ee, Southey, Melissa C., Hopper, John L., Abramson, Michael J., Li, Shuai, Guo, Yuming

“…•This is the first study to assess the epigenetic impact of short-term temperature fluctuations.•Significant changes in methylation levels in 14…”
Get full text

Blood DNA methylation score predicts breast cancer risk: applying OPERA in molecular, environmental, genetic and analytic epidemiology by Hopper, John L., Nguyen, Tuong L., Li, Shuai

“…In this issue, Kresovich and colleagues have published a hallmark paper in Molecular, Environmental, Genetic and Analytic Epidemiology. By applying artificial…”
Get full text

Tamoxifen and Risk of Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers by PHILLIPS, Kelly-Anne, MILNE, Roger L, BUYS, Saundra S, ANDRIEU, Nadine, NOGUES, Catherine, STOPPA-LYONNET, Dominique, BONADONA, Valérie, PUJOL, Pascal, MCLACHLAN, Sue Anne, JOHN, Esther M, HOONING, Maartje J, SEYNAEVE, Caroline, ROOKUS, Matti A, TOLLENAAR, Rob A. E. M, GOLDGAR, David E, TERRY, Mary Beth, CALDES, Trinidad, WEIDEMAN, Prue C, ANDRULIS, Irene L, SINGER, Christian F, BIRCH, Kate, SIMARD, Jacques, SOUTHEY, Melissa C, DALY, Mary B, OLSSON, Håkan L, JAKUBOWSKA, Anna, OLAH, Edith, GERDES, Anne-Marie, FORETOVA, Lenka, HOPPER, John L, ANTONIOU, Antonis C, PEOCK, Susan, FROST, Debra, EASTON, Douglas F, ELLIS, Steve, FRIEDLANDER, Michael L

“…To determine whether adjuvant tamoxifen treatment for breast cancer (BC) is associated with reduced contralateral breast cancer (CBC) risk for BRCA1 and/or…”
Get full text

The Clinical Phenotype of Lynch Syndrome Due to Germ-Line PMS2 Mutations by Senter, Leigha, Clendenning, Mark, Sotamaa, Kaisa, Hampel, Heather, Green, Jane, Potter, John D, Lindblom, Annika, Lagerstedt, Kristina, Thibodeau, Stephen N, Lindor, Noralane M, Young, Joanne, Winship, Ingrid, Dowty, James G, White, Darren M, Hopper, John L, Baglietto, Laura, Jenkins, Mark A, de la Chapelle, Albert

“…Background & Aims: Although the clinical phenotype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer) has been well described, little…”
Get full text