Search Results - "Hoppel, Charles L"

Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies by Lesnefsky, Edward J, Chen, Qun, Tandler, Bernard, Hoppel, Charles L

“…Mitochondria have emerged as key participants in and regulators of myocardial injury during ischemia and reperfusion. This review examines the sites of damage…”
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Mitochondrial Metabolism in Aging Heart by Lesnefsky, Edward J, Chen, Qun, Hoppel, Charles L

“…Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the aged heart to stress. The aged heart exhibits impaired metabolic…”
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Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex by Lee, Kwangwon, Kerner, Janos, Hoppel, Charles L.

“…CPT1a (carnitine palmitoyltransferase 1a) in the liver mitochondrial outer membrane (MOM) catalyzes the primary regulated step in overall mitochondrial fatty…”
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HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism by Du, Weinan, Zhang, Luchang, Brett-Morris, Adina, Aguila, Brittany, Kerner, Janos, Hoppel, Charles L., Puchowicz, Michelle, Serra, Dolors, Herrero, Laura, Rini, Brian I., Campbell, Steven, Welford, Scott M.

“…Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-rich cytoplasmic deposits. Alterations in the VHL tumor suppressor…”
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The Failing Heart Relies on Ketone Bodies as a Fuel by Aubert, Gregory, Martin, Ola J, Horton, Julie L, Lai, Ling, Vega, Rick B, Leone, Teresa C, Koves, Timothy, Gardell, Stephen J, Krüger, Marcus, Hoppel, Charles L, Lewandowski, E Douglas, Crawford, Peter A, Muoio, Deborah M, Kelly, Daniel P

“…Significant evidence indicates that the failing heart is energy starved. During the development of heart failure, the capacity of the heart to utilize fatty…”
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Identification of unusual phospholipids from bovine heart mitochondria by HPLC-MS/MS by Kim, Junhwan, Hoppel, Charles L.

“…Phospholipids, including ether phospholipids, are composed of numerous isomeric and isobaric species that have the same backbone and acyl chains. This…”
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Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women by Fiehn, Oliver, Garvey, W. Timothy, Newman, John W, Lok, Kerry H, Hoppel, Charles L, Adams, Sean H, Gimble, Jeffrey M

“…Insulin resistance progressing to type 2 diabetes mellitus (T2DM) is marked by a broad perturbation of macronutrient intermediary metabolism. Understanding the…”
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Dysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction and senescence by inhibiting sirtuin‐mediated deacetylation by Mishra, Saurabh, Welch, Nicole, Karthikeyan, Manikandan, Bellar, Annette, Musich, Ryan, Singh, Shashi Shekhar, Zhang, Dongmei, Sekar, Jinendiran, Attaway, Amy H., Chelluboyina, Aruna Kumar, Lorkowski, Shuhui Wang, Roychowdhury, Sanjoy, Li, Ling, Willard, Belinda, Smith, Jonathan D., Hoppel, Charles L., Vachharajani, Vidula, Kumar, Avinash, Dasarathy, Srinivasan

“…Perturbed metabolism of ammonia, an endogenous cytotoxin, causes mitochondrial dysfunction, reduced NAD+/NADH (redox) ratio, and postmitotic senescence…”
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Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria by Chen, Qun, Moghaddas, Shadi, Hoppel, Charles L, Lesnefsky, Edward J

“…Cardiac ischemia decreases complex III activity, cytochrome c content, and respiration through cytochrome oxidase in subsarcolemmal mitochondria (SSM) and…”
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Involvement of All-trans-retinal in Acute Light-induced Retinopathy of Mice by Maeda, Akiko, Maeda, Tadao, Golczak, Marcin, Chou, Steven, Desai, Amar, Hoppel, Charles L., Matsuyama, Shigemi, Palczewski, Krzysztof

“…Exposure to bright light can cause visual dysfunction and retinal photoreceptor damage in humans and experimental animals, but the mechanism(s) remain unclear…”
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Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes by ROSCA, Mariana G, VAZQUEZ, Edwin J, QUN CHEN, KERNER, Janos, KERN, Timothy S, HOPPEL, Charles L

“…Mitochondrial reactive oxygen species (ROS) cause kidney damage in diabetes. We investigated the source and site of ROS production by kidney cortical tubule…”
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Dynamic organization of mitochondria in human heart and in myocardial disease by Hoppel, Charles L., Tandler, Bernard, Fujioka, Hisashi, Riva, Alessandro

“…Heart mitochondria, which, depending on their location within cardiomyofibers, are classified as either subsarcolemmal or interfibrillar, are the major sources…”
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Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response by Gao, Xing-Huang, Krokowski, Dawid, Guan, Bo-Jhih, Bederman, Ilya, Majumder, Mithu, Parisien, Marc, Diatchenko, Luda, Kabil, Omer, Willard, Belinda, Banerjee, Ruma, Wang, Benlian, Bebek, Gurkan, Evans, Charles R, Fox, Paul L, Gerson, Stanton L, Hoppel, Charles L, Liu, Ming, Arvan, Peter, Hatzoglou, Maria

“…The sulfhydration of cysteine residues in proteins is an important mechanism involved in diverse biological processes. We have developed a proteomics approach…”
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Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation by Rosca, Mariana G., Vazquez, Edwin J., Kerner, Janos, Parland, William, Chandler, Margaret P., Stanley, William, Sabbah, Hani N., Hoppel, Charles L.

“…Aims Mitochondrial dysfunction is a major factor in heart failure (HF). A pronounced variability of mitochondrial electron transport chain (ETC) defects is…”
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Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass by Akinbiyi, Elizabeth O., Abramowitz, Lara K., Bauer, Brianna L., Stoll, Maria S. K., Hoppel, Charles L., Hsiao, Chao-Pin, Hanover, John A., Mears, Jason A.

“…O -GlcNAcylation is a prevalent form of glycosylation that regulates proteins within the cytosol, nucleus, and mitochondria. The O -GlcNAc modification can…”
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Urinary acylcarnitines are altered in human kidney cancer by Ganti, Sheila, Taylor, Sandra L., Kim, Kyoungmi, Hoppel, Charles L., Guo, Lining, Yang, Joy, Evans, Christopher, Weiss, Robert H.

“…Kidney cancer often diagnosed at late stages when treatment options are severely limited. Thus, greater understanding of tumor metabolism leading ultimately to…”
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Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis by Liao, Xudong, Zhang, Rongli, Lu, Yuan, Prosdocimo, Domenick A, Sangwung, Panjamaporn, Zhang, Lilei, Zhou, Guangjin, Anand, Puneet, Lai, Ling, Leone, Teresa C, Fujioka, Hisashi, Ye, Fang, Rosca, Mariana G, Hoppel, Charles L, Schulze, P Christian, Abel, E Dale, Stamler, Jonathan S, Kelly, Daniel P, Jain, Mukesh K

“…Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have…”
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Separation and characterization of cardiolipin molecular species by reverse-phase ion pair high-performance liquid chromatography-mass spectrometry by Minkler, Paul E, Hoppel, Charles L

“…An improved high-performance liquid chromatography-mass spectrometry method for the separation and characterization of cardiolipin molecular species is…”
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Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion by Chen, Qun, Moghaddas, Shadi, Hoppel, Charles L, Lesnefsky, Edward J

“…Cardiac mitochondria sustain damage during ischemia and reperfusion, contributing to cell death. The reversible blockade of electron transport during ischemia…”
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VDAC proteomics: Post-translation modifications by Kerner, Janos, Lee, Kwangwon, Tandler, Bernard, Hoppel, Charles L.

“…Voltage-dependent anion channels are abundant mitochondrial outer membrane proteins expressed in three isoforms, VDAC1-3, and are considered as “mitochondrial…”
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