Search Results - "Hoppe, Michal"

Biomarkers for Homologous Recombination Deficiency in Cancer by Hoppe, Michal M, Sundar, Raghav, Tan, David S P, Jeyasekharan, Anand D

“…Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA repair pathway of clinical interest due to the sensitivity of homologous…”
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Biomarkers for Homologous Recombination Deficiency in Cancer by Hoppe, Michal M, Sundar, Raghav, Tan, David S P, Jeyasekharan, Anand D

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Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer by Hoppe, Michal M, Jaynes, Patrick, Wardyn, Joanna D, Upadhyayula, Sai Srinivas, Tan, Tuan Zea, Lie, Stefanus, Lim, Diana G Z, Pang, Brendan N K, Lim, Sherlly, P S Yeong, Joe, Karnezis, Anthony, Chiu, Derek S, Leung, Samuel, Huntsman, David G, Sedukhina, Anna S, Sato, Ko, Topp, Monique D, Scott, Clare L, Choi, Hyungwon, Patel, Naina R, Brown, Robert, Kaye, Stan B, Pitt, Jason J, Tan, David S P, Jeyasekharan, Anand D

“…Early relapse after platinum chemotherapy in epithelial ovarian cancer (EOC) portends poor survival. A‐priori identification of platinum resistance is…”
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p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain) by Teoh, Phaik Ju, An, Omer, Chung, Tae-Hoon, Vaiyapuri, Thamil, Raju, Anandhkumar, Hoppe, Michal M., Toh, Sabrina H. M., Wang, Wilson, Chan, Ming Chun, Fullwood, Melissa J., Jeyasekharan, Anand D., Tergaonkar, Vinay, Chen, Leilei, Yang, Henry, Chng, Wee Joo

“…Recurrent cytogenetic abnormalities are the main hallmark of multiple myeloma (MM) and patients having 2 or more high-risk prognostic events are associated…”
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An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma by Goh, Jasmine, De Mel, Sanjay, Hoppe, Michal M, Mohd Abdul Rashid, Masturah Bte, Zhang, Xi Yun, Jaynes, Patrick, Ka Yan Ng, Esther, Rahmat, Nur'Atiqa Diana Binti, Jayalakshmi, Liu, Clementine Xin, Poon, Limei, Chan, Esther, Lee, Joanne, Chee, Yen Lin, Koh, Liang Piu, Tan, Lip Kun, Soh, Teck Guan, Yuen, Yi Ching, Loi, Hoi-Yin, Ng, Siok-Bian, Goh, Xueying, Eu, Donovan, Loh, Stanley, Ng, Sheldon, Tan, Daryl, Cheah, Daryl Ming Zhe, Pang, Wan Lu, Huang, Dachuan, Ong, Shin Yeu, Nagarajan, Chandramouli, Chan, Jason Yongsheng, Ha, Jeslin Chian Hung, Khoo, Lay Poh, Somasundaram, Nagavalli, Tang, Tiffany, Ong, Choon Kiat, Chng, Wee-Joo, Lim, Soon Thye, Chow, Edward K, Jeyasekharan, Anand D

“…Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin's lymphoma (RR-NHL), combination treatment chosen for an individual…”
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PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production by Srinivas, Upadhyayula S., Tay, Norbert S. C., Jaynes, Patrick, Anbuselvan, Akshaya, Ramachandran, Gokula K., Wardyn, Joanna D., Hoppe, Michal M., Hoang, Phuong Mai, Peng, Yanfen, Lim, Sherlly, Lee, May Yin, Peethala, Praveen C., An, Omer, Shendre, Akshay, Tan, Bryce W. Q., Jemimah, Sherlyn, Lakshmanan, Manikandan, Hu, Longyu, Jakhar, Rekha, Sachaphibulkij, Karishma, Lim, Lina H. K., Pervaiz, Shazib, Crasta, Karen, Yang, Henry, Tan, Patrick, Liang, Chao, Ho, Lena, Khanchandani, Vartika, Kappei, Dennis, Yong, Wei Peng, Tan, David S. P., Bordi, Matteo, Campello, Silvia, Tam, Wai Leong, Frezza, Christian, Jeyasekharan, Anand D.

“…Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate…”
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Correction: PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production by Srinivas, Upadhyayula S., Tay, Norbert S. C., Jaynes, Patrick, Anbuselvan, Akshaya, Ramachandran, Gokula K., Wardyn, Joanna D., Hoppe, Michal M., Hoang, Phuong Mai, Peng, Yanfen, Lim, Sherlly, Lee, May Yin, Peethala, Praveen C., An, Omer, Shendre, Akshay, Tan, Bryce W. Q., Jemimah, Sherlyn, Lakshmanan, Manikandan, Hu, Longyu, Jakhar, Rekha, Sachaphibulkij, Karishma, Lim, Lina H. K., Pervaiz, Shazib, Crasta, Karen, Yang, Henry, Tan, Patrick, Liang, Chao, Ho, Lena, Khanchandani, Vartika, Kappei, Dennis, Yong, Wei Peng, Tan, David S. P., Bordi, Matteo, Campello, Silvia, Tam, Wai Leong, Frezza, Christian, Jeyasekharan, Anand D.

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Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial by Sundar, Raghav, Barr Kumarakulasinghe, Nesaretnam, Huak Chan, Yiong, Yoshida, Kazuhiro, Yoshikawa, Takaki, Miyagi, Yohei, Rino, Yasushi, Masuda, Munetaka, Guan, Jia, Sakamoto, Junichi, Tanaka, Shiro, Tan, Angie Lay-Keng, Hoppe, Michal Marek, Jeyasekharan, Anand D, Ng, Cedric Chuan Young, De Simone, Mark, Grabsch, Heike I, Lee, Jeeyun, Oshima, Takashi, Tsuburaya, Akira, Tan, Patrick

“…To date, there are no predictive biomarkers to guide selection of patients with gastric cancer (GC) who benefit from paclitaxel. Stomach cancer Adjuvant…”
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CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer by Roy, Rony K, Hoppe, Michal M, Srivastava, Supriya, Samanta, Animesh, Sharma, Neel, Tan, Kar Tong, Yang, Henry, Voon, Dominic C, Pang, Brendan, Teh, Ming, Murata-Kamiya, Naoko, Hatakeyama, Masanori, Chang, Young-Tae, Yong, Wei Peng, Ito, Yoshiaki, Ho, Khek Yu, Tan, Patrick, Soong, Richie, Koeffler, Phillip H, Yeoh, Khay Guan, Jeyasekharan, Anand D

“…Early detection of gastric cancers saves lives, but remains a diagnostic challenge. In this study, we aimed to identify cell-surface biomarkers of early…”
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Epstein-Barr virus-associated primary nodal T/NK-cell lymphoma shows a distinct molecular signature and copy number changes by Ng, Siok-Bian, Chung, Tae-Hoon, Kato, Seiichi, Nakamura, Shigeo, Takahashi, Emiko, Ko, Young-Hyeh, Khoury, Joseph D, Yin, C Cameron, Soong, Richie, Jeyasekharan, Anand D, Hoppe, Michal Marek, Selvarajan, Viknesvaran, Tan, Soo-Yong, Lim, Soon-Thye, Ong, Choon-Kiat, Nairismägi, Maarja-Liisa, Maheshwari, Priyanka, Choo, Shoa-Nian, Fan, Shuangyi, Lee, Chi-Kuen, Chuang, Shih-Sung, Chng, Wee-Joo

“…The molecular biology of primary nodal T- and NK-cell lymphoma and its relationship with extranodal NK/T-cell lymphoma, nasal type is poorly understood. In…”
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The contribution of MYC and PLK1 expression to proliferative capacity in diffuse large B-cell lymphoma by Oon, Ming Liang, Hoppe, Michal M., Fan, Shuangyi, Phyu, The, Phuong, Hoang M., Tan, Soo-Yong, Hue, Susan Swee-Shan, Wang, Shi, Poon, Li M., Chan, Hian L. E., Lee, Joanne, Chee, Yen L., Chng, Wee-Joo, de Mel, Sanjay, Liu, Xin, Jeyasekharan, Anand D., Ng, Siok-Bian

“…Polo-like kinase-1 (PLK1) regulates the MYC-dependent kinome in aggressive B-cell lymphoma. However, the role of PLK1 and MYC toward proliferation in diffuse…”
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PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis by Mzoughi, Slim, Fong, Jia Yi, Papadopoli, David, Koh, Cheryl M., Hulea, Laura, Pigini, Paolo, Di Tullio, Federico, Andreacchio, Giuseppe, Hoppe, Michal Marek, Wollmann, Heike, Low, Diana, Caldez, Matias J., Peng, Yanfen, Torre, Denis, Zhao, Julia N., Uchenunu, Oro, Varano, Gabriele, Motofeanu, Corina-Mihaela, Lakshmanan, Manikandan, Teo, Shun Xie, Wun, Cheng Mun, Perini, Giovanni, Tan, Soo Yong, Ong, Chee Bing, Al-Haddawi, Muthafar, Rajarethinam, Ravisankar, Hue, Susan Swee-Shan, Lim, Soon Thye, Ong, Choon Kiat, Huang, Dachuan, Ng, Siok-Bian, Bernstein, Emily, Hasson, Dan, Wee, Keng Boon, Kaldis, Philipp, Jeyasekharan, Anand, Dominguez-sola, David, Topisirovic, Ivan, Guccione, Ernesto

“…PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate…”
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Low Levels of NDRG1 in Nerve Tissue Are Predictive of Severe Paclitaxel-Induced Neuropathy by Sundar, Raghav, Jeyasekharan, Anand D, Pang, Brendan, Soong, Richie Chuan Teck, Kumarakulasinghe, Nesaretnam Barr, Ow, Samuel Guan Wei, Ho, Jingshan, Lim, Joline Si Jing, Tan, David Shao Peng, Wilder-Smith, Einar P V, Bandla, Aishwarya, Tan, Stacey Sze Hui, Asuncion, Bernadette Reyna, Fazreen, Zul, Hoppe, Michal Marek, Putti, Thomas Choudary, Poh, Lay Mui, Goh, Boon Cher, Lee, Soo-Chin

“…Sensory peripheral neuropathy caused by paclitaxel is a common and dose limiting toxicity, for which there are currently no validated predictive biomarkers. We…”
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Profiling of gastric cancer cell-surface markers to achieve tumour–normal discrimination by Toh, Judith, Hoppe, Michal Marek, Thakur, Teena, Yang, Henry, Tan, Kar Tong, Pang, Brendan, Ho, Sharmaine, Roy, Rony, Ho, Khek Yu, Yeoh, Khay Guan, Tan, Patrick, Sundar, Raghav, Jeyasekharan, Anand

“…Background Differentiating between malignant and normal cells within tissue samples is vital for molecular profiling of cancer using advances in genomics and…”
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Abstract 2443: APOBEC3G is a sex-specific determinant of post-transcriptional RNA processing and survival in diffuse large B-cell lymphoma by Wardyn, Joanna D., Hoppe, Michal M., Chan, Allison S., Li, Jia, An, Omer, Venguidessane, Shruthi, Sheng, Dominic P., Yang, Henry, Yeo, Gene W., Hodson, Daniel J., Harris, Reuben S., Jeyasekharan, Anand D.

“…Abstract APOBEC3G is a cytidine deaminase with a well-characterized anti-viral role against HIV and other retroviruses. Its deaminase activity yields G to A…”
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Abstract 3648: The spatial organization of cells expressing MYC and BCL2 affects immune microenvironment composition and prognosis in DLBCL by Shridar, Shruti, Hoppe, Michal Marek, Jaynes, Patrick, Kumar, Gayatri, Jasoria, Siddham, Meng, Ziwei, Rajan, Vaibhav, Kannan, Kasthuri, Tripodo, Claudio, Jeyasekharan, Anand Devaprasath

“…Abstract Point process analyses are widely used in ecology and geography to understand the impact and relevance of spatial distribution of points in a complex…”
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Quantitative Analysis of Multiplexed Immunofluorescence in T-Cell Lymphoma by de Mel, Sanjay, Choo, Shou- Nian, Fan, Shuangyi, Phuong, Hoang Mai, Hoppe, Michal, Chng, Wee Joo, Jeyasekharan, Anand, Ng, Siok Bian

“…Introduction Immunohistochemistry provides biologically and clinically useful information on protein expression and cellular localization in cancer cells, but…”
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Clinical Application of an Ex-Vivo Platform to Guide the Choice of Drug Combinations in Relapsed/Refractory Lymphoma; A Prospective Study by De Mel, Sanjay, Goh, Jasmine, Rashid, Masturah, Hoppe, Michal, Zhang, Xi Yun, Jaynes, Patrick, Ng, Esther KY, Rahmat, Nur Atiqa Diana Binte, Liu, Xin, Poon, Michelle, Chan, Hian Li Esther, Lee, Joanne, Chee, Yen-Lin, Koh, Liang Piu, Tan, Lip Kun, Soh, Teck Guan, Yuen, Yi Ching, Loi, Hoi Yin, Ng, Siok Bian, Goh, Xueying, Tan, Daryl, Cheah, Daryl Ming Zhe, Pang, Wan Lu, Huang, Dachuan, Somasundaram, Nagavalli, Tang, Tiffany, Chan, Jason Yongsheng, Lim, Soon Thye, Ong, Choon Kiat, Chng, Wee Joo, Chow, Edward KH, Jeyasekharan, Anand

“…Introduction While combination therapy is the standard of care for relapsed/ refractory non-Hodgkin lymphoma (RR-NHL), the choice of combinations for an…”
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Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma by Hoppe, Michal Marek, Jaynes, Patrick, Shuangyi, Fan, Peng, Yanfen, Sridhar, Shruti, Hoang, Phuong Mai, Liu, Clementine Xin, De Mel, Sanjay, Poon, Limei, Chan, Esther Hian Li, Lee, Joanne, Ong, Choon Kiat, Tang, Tiffany, Lim, Soon Thye, Nagarajan, Chandramouli, Grigoropoulos, Nicholas F, Tan, Soo-Yong, Hue, Susan Swee-Shan, Chang, Sheng-Tsung, Chuang, Shih-Sung, Li, Shaoying, Khoury, Joseph D, Choi, Hyungwon, Harris, Carl, Bottos, Alessia, Gay, Laura J, Runge, Hendrik F P, Moutsopoulos, Ilias, Mohorianu, Irina, Hodson, Daniel J, Farinha, Pedro, Mottok, Anja, Scott, David W, Pitt, Jason J, Chen, Jinmiao, Kumar, Gayatri, Kannan, Kasthuri, Chng, Wee Joo, Chee, Yen Lin, Ng, Siok-Bian, Tripodo, Claudio, Jeyasekharan, Anand D

“…Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer…”
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Abstract B04: RAD51 expression as a biomarker of homologous recombination deficiency in ovarian cancer by Hoppe, Michal M., Tan, David SP, Lim, Diana GZ, Karnezis, Anthony, Huntsman, David, Steel, Jennifer, Liu, Xinxue, Paul, James, Lewsley, Liz-Anne, Siddiqui, Nadeem, Brown, Robert, Jeyasekharan, Anand D.

“…Abstract RAD51 is a critical component of the homologous recombination pathway, forming a nucleoprotein filament that enables strand exchange and templated…”
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