Search Results - "Hopman, Anton H. N."

Inhibition of cytosine 5-hydroxymethylation during progression of cancer precursor lesions in the uterine cervix by Moshi, Jobran M, Ummelen, Monique, Smedts, Frank, Ramaekers, Frans C S, Hopman, Anton H N

“…Methylation and hydroxymethylation of cytosine moieties in CpG islands of specific genes are epigenetic processes shown to be involved in the development of…”
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Switches of SOX17 and SOX2 expression in the development of squamous metaplasia and squamous intraepithelial lesions of the uterine cervix by Moshi, Jobran M., Hoogduin, Klaas J., Ummelen, Monique, Henfling, Mieke E. R., Engeland, Manon, Wouters, Kim A. D., Stoop, Hans, Demers, Imke, Looijenga, Leendert H. J., Ramaekers, Frans C. S., Hopman, Anton N. H.

“…Aims The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a…”
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Chromosome stability in tonsillar squamous cell carcinoma is associated with HPV16 integration and indicates a favorable prognosis by Mooren, Jeroen J., Kremer, Bernd, Claessen, Sandra M.H., Voogd, Adri C., Bot, Fredrik J., Peter Klussmann, J., Huebbers, Christian U., Hopman, Anton H.N., Ramaekers, Frans C.S., Speel, Ernst‐Jan M.

“…Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems…”
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Impact of antigen retrieval protocols on the immunohistochemical detection of epigenetic DNA modifications by Moshi, Jobran M., Ummelen, Monique, Broers, Jos L. V., Ramaekers, Frans C. S., Hopman, Anton H. N.

“…This study compares three different pretreatment protocols for the immunohistochemical detection of 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC)…”
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Distribution Pattern and Marker Profile Show Two Subpopulations of Reserve Cells in the Endocervical Canal by Martens, Jolise E, Smedts, Frank M. M, Ploeger, Diana, Helmerhorst, Theo J. M, Ramaekers, Frans C. S, Arends, Jan W, Hopman, Anton H. N

“…A previous immunophenotyping study in the fetal uterine cervix provided evidence for the existence of 2 subpopulations of reserve cells, one giving rise to…”
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SOX2 expression in the pathogenesis of premalignant lesions of the uterine cervix: its histo-topographical distribution distinguishes between low- and high-grade CIN by Moshi, Jobran M., Ummelen, Monique, Broers, Jos L. V., Smedts, Frank, Van de Vijver, Koen K., Cleutjens, Jack P. M., Litjens, Rogier J. N. T. M., Ramaekers, Frans C. S., Hopman, Anton H. N.

“…SOX2 expression in high-grade cervical intraepithelial neoplasia (CIN3) and cervical squamous cell carcinoma is increased compared to that in the normal…”
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Mesenchymal stem cells induce T-cell tolerance and protect the preterm brain after global hypoxia-ischemia by Jellema, Reint K, Wolfs, Tim G A M, Lima Passos, Valéria, Zwanenburg, Alex, Ophelders, Daan R M G, Kuypers, Elke, Hopman, Anton H N, Dudink, Jeroen, Steinbusch, Harry W, Andriessen, Peter, Germeraad, Wilfred T V, Vanderlocht, Joris, Kramer, Boris W

“…Hypoxic-ischemic encephalopathy (HIE) in preterm infants is a severe disease for which no curative treatment is available. Cerebral inflammation and invasion…”
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Genetic Signatures of HPV-related and Unrelated Oropharyngeal Carcinoma and Their Prognostic Implications by KLUSSMANN, Jens P, MOOREN, Jeroen J, MANNI, JohannesJ, HOPMAN, Anton H. N, SPEEL, Ernst-Jan M, LEHNEN, Martin, CLAESSEN, Sandra M. H, STERNER, Markus, HUEBBERS, Christian U, WEISSENBORN, Soenke J, WEDEMEYER, Inga, PREUSS, Simon F, STRAETMANS, Jos M. J. A. A

“…Purpose: Patients with human papillomavirus (HPV)-containing oropharyngeal squamous cell carcinomas (OSCC) have a better prognosis than patients with…”
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Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions by Litjens, Rogier J.N.T.M., Theelen, Wendy, van de Pas, Yvonne, Ossel, Jessica, Reijans, Martin, Simons, Guus, Speel, Ernst-Jan M., Slangen, Brigitte F.M., Ramaekers, Frans C.S., Kruitwagen, Roy F.P.M., Hopman, Anton H.N.

“…ABSTRACT Current screening methods for uterine cervical cancer such as Papanicolaou smears and/or high risk human Papillomavirus (HR‐HPV) detection have a high…”
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The Proliferation Index of Erythroid Cells Predicts the Development of Transfusion‐dependence in Myelodysplastic Syndrome Patients With Mildly Reduced Hemoglobin Levels at Initial Diagnosis by Mestrum, Stefan G. C., Wit, Norbert C. J., Cremers, Eline M. P., Drent, Roosmarie J. M., Ramaekers, Frans C. S., Hopman, Anton H. N., Leers, Math P. G.

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Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities by Hopman, Anton HN, Smedts, Frank, Dignef, Wendy, Ummelen, Monique, Sonke, Gabe, Mravunac, Marcel, Vooijs, G Peter, Speel, Ernst-Jan M, Ramaekers, Frans CS

“…Cervical intraepithelial neoplasia (CIN I, II, and III) and cases of CIN III associated with micro‐invasive cervical carcinoma (CIN III & mCA) were analysed…”
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Increase in Viral Load, Viral Integration, and Gain of Telomerase Genes during Uterine Cervical Carcinogenesis can be Simultaneously Assessed by the HPV 16/18 MLPA-Assay by Theelen, Wendy, Speel, Ernst-Jan M, Herfs, Michael, Reijans, Martin, Simons, Guus, Meulemans, Els V, Baldewijns, Marcella M, Ramaekers, Frans C.S, Somja, Joan, Delvenne, Philippe, Hopman, Anton H.N

“…Oncogenic human papillomavirus (HPV) infection is the most important risk factor in cervical carcinogenesis cases; high viral loads, viral integration into the…”
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A new multiparameter assay to assess HPV 16/18, viral load and physical status together with gain of telomerase genes in HPV‐related cancers by Theelen, Wendy, Reijans, Martin, Simons, Guus, Ramaekers, Frans C.S., Speel, Ernst‐Jan M., Hopman, Anton H.N.

“…Oncogenic human papillomavirus (HPV) is the most important risk factor for cancer of the uterine cervix and a subgroup of head and neck cancers. Viral load has…”
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Diagnostic Value of Processing Cytologic Aspirates of Renal Tumors in Agar Cell (Tissue) Blocks by Smedts, Frank, Schrik, Maria, Horn, Thomas, Hopman, Anton H.N.

“…To adapt a method enabling utilization of most of the harvest from a fine needle aspirate in an effort to improve diagnostic accuracy in the assessment of a…”
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Human papillomavirus multiplex ligation-dependent probe amplification assay for the assessment of viral load, integration, and gain of telomerase-related genes in cervical malignancies by Theelen, Wendy, PhD, Litjens, Rogier J.N.T.M., MD, Vinokurova, Svetlana, PhD, Haesevoets, Annick, Reijans, Martin, MSc, Simons, Guus, PhD, Smedts, Frank, PhD, MD, Herrington, C. Simon, PhD, MD, Ramaekers, Frans C.S., PhD, von Knebel Doeberitz, Magnus, PhD, MD, Speel, Ernst-Jan M., PhD, Hopman, Anton H.N., PhD

“…Summary We evaluated the reliability of a novel multiplex ligation-dependent probe amplification (MLPA) assay in detecting integration of human papillomavirus…”
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The majority of metachronous CIN1 and CIN3 lesions are caused by different human papillomavirus genotypes, indicating that the presence of CIN1 seems not to determine the risk for subsequent detection of CIN3 by Litjens, Rogier J.N.T.M., MD, Van de Vijver, Koen K., MD, PhD, Hopman, Anton H.N., PhD, Ummelen, Monique I, Speel, Ernst-Jan M., PhD, Sastrowijoto, Suprapto H., MD, PhD, Van Gorp, Toon, MD, PhD, Slangen, Brigitte F.M., MD, PhD, Kruitwagen, Roy F.P.M., MD, PhD, Krüse, Arnold-Jan, MD, PhD

“…Summary Cervical intraepithelial neoplasia (CIN) is historically viewed as a progressive biologic continuum leading to cervical cancer. However, it has been…”
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The Two Faces of Cervical Adenocarcinoma In Situ by Smedts, Frank, Ramaekers, Frans C.S, Hopman, Anton H.N

“…In order of frequency, cervical intraepithelial neoplasia (CIN), combined adenocarcinoma in situ (AIS)/CIN lesions, and solitary AIS are the most prevalent…”
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HPV in situ hybridization: Impact of different protocols on the detection of integrated HPV by Hopman, Anton H.N., Kamps, Miriam A., Smedts, Frank, Speel, Ernst‐Jan M., Herrington, C. Simon, Ramaekers, Frans C.S.

“…Although there is consensus that HPV integration is common in invasive cervical carcinomas and uncommon or absent in low‐grade uterine cervical intraepithelial…”
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MDS and AML show elevated fractions of CD34-positive blast cell populations with a high anti-apoptotic versus proliferation ratio by Mestrum, Stefan G.C., Roanalis, B.Y. Vanblarcum, de Wit, Norbert C.J., Drent, Roosmarie J.M., Boonen, Bert T., van Hemert, Wouter L.W., Hopman, Anton H.N., Ramaekers, Frans C.S., Leers, Math P.G.

“…This study investigates the intertwined processes of (anti-)apoptosis and cell proliferation in myelodysplastic syndromes (MDS) and acute myeloid leukemia…”
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SOX17 expression and its down‐regulation by promoter methylation in cervical adenocarcinoma in situ and adenocarcinoma by Hopman, Anton N H, Moshi, Jobran M, Hoogduin, Klaas J, Ummelen, Monique, Henfling, Mieke E R, Engeland, Manon, Wouters, Kim A D, Stoop, Hans, Looijenga, Leendert H J, Ramaekers, Frans C S

“…Aims SOX17 expression has not been studied in glandular lesions of the uterine cervix like adenocarcinoma in situ (AIS) and invasive adenocarcinomas (AdC),…”
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