Search Results - "Hopkins, Suzanna R."

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability by Meisenberg, Cornelia, Pinder, Sarah I., Hopkins, Suzanna R., Wooller, Sarah K., Benstead-Hume, Graeme, Pearl, Frances M.G., Jeggo, Penny A., Downs, Jessica A.

“…Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this…”
Get full text

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks by Benstead-Hume, Graeme, Chen, Xiangrong, Hopkins, Suzanna R, Lane, Karen A, Downs, Jessica A, Pearl, Frances M G

“…In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal…”
Get full text

Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180 by Hopkins, Suzanna R., McGregor, Grant A., Murray, Johanne M., Downs, Jessica A., Savic, Velibor

“…In recent years, research into synthetic lethality and how it can be exploited in cancer treatments has emerged as major focus in cancer research. However, the…”
Get full text

The BAH domain of BAF180 is required for PCNA ubiquitination by Niimi, Atsuko, Hopkins, Suzanna R, Downs, Jessica A, Masutani, Chikahide

“…Monoubiquitination of proliferating cell nuclear antigen (PCNA) is a critical regulator of post replication repair (PRR). The depletion of BAF180, a unique…”
Get more information

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer by Chabanon, Roman M, Morel, Daphné, Eychenne, Thomas, Colmet-Daage, Léo, Bajrami, Ilirjana, Dorvault, Nicolas, Garrido, Marlène, Meisenberg, Cornelia, Lamb, Andrew, Ngo, Carine, Hopkins, Suzanna R, Roumeliotis, Theodoros I, Jouny, Samuel, Hénon, Clémence, Kawai-Kawachi, Asuka, Astier, Clémence, Konde, Asha, Del Nery, Elaine, Massard, Christophe, Pettitt, Stephen J, Margueron, Raphaël, Choudhary, Jyoti S, Almouzni, Geneviève, Soria, Jean-Charles, Deutsch, Eric, Downs, Jessica A, Lord, Christopher J, Postel-Vinay, Sophie

“…Inactivation of ( ), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell…”
Get full text

Distinct response of adult neural stem cells to low versus high dose ionising radiation by Barazzuol, Lara, Hopkins, Suzanna R., Ju, Limei, Jeggo, Penelope A.

“…•Apoptosis arises linearly with the radiation dose in adult neural progenitor cells.•Proliferation arrest and differentiation are inefficiently activated at…”
Get full text