Search Results - "Hopkins, Penelope J."

Associations Between Drug Metabolism Genotype, Chemotherapy Pharmacokinetics, and Overall Survival in Patients With Breast Cancer by PETROS, William P, HOPKINS, Penelope J, SPRUILL, Susan, BROADWATER, Gloria, VREDENBURGH, James J, COLVIN, . Michael, PETERS, William P, JONES, Roy B, HALL, Jeff, MARKS, Jeffrey R

“…To evaluate associations between patient survival, pharmacokinetics, and drug metabolism-related genetic polymorphisms in patients receiving a combination…”
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Population distribution and effects on drug metabolism of a genetic variant in the 5′ promotor region of CYP3A4 by Ball, Simon E., Scatina, JoAnn, Kao, John, Ferron, Geraldine M., Fruncillo, Richard, Mayer, Philip, Weinryb, Ira, Guida, Marco, Hopkins, Penelope J., Warner, Natalie, Hall, Jeff

“…Background There are large interindividual differences in CYP3A4 expression and in the metabolism of drug substrates for this enzyme. We and others have…”
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Relation between tumour necrosis factor polymorphism TNFα-308 and risk of asthma by Witte, John S, Palmer, Lyle J, O'Connor, Richard D, Hopkins, Penelope J, Hall, Jeff M

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X-Linked Chronic Granulomatous Disease: Mutations in the CYBB Gene Encoding the gp91- phox Component of Respiratory-Burst Oxidase by Rae, Julie, Newburger, Peter E., Dinauer, Mary C., Noack, Deborah, Hopkins, Penelope J., Kuruto, Ryoko, Curnutte, John T.

“…Chronic granulomatous disease (CGD) is a hereditary disorder of host defense due to absent or decreased activity of phagocyte NADPH oxidase. The X-linked form…”
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A genome-wide search for schizophrenia susceptibility genes by Shaw, Sarah H., Kelly, Mary, Smith, Angela B., Shields, Gail, Hopkins, Penelope J., Loftus, Josephine, Laval, Steven H., Vita, Antonio, De Hert, Marc, Cardon, Lon R., Crow, Timothy J., Sherrington, Robin, DeLisi, Lynn E.

“…We completed a systematic genome‐wide search for evidence of loci linked to schizophrenia using a collection of 70 pedigrees containing multiple affected…”
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Separation of Simulants of Biological Warfare Agents from Blood by a Miniaturized Dielectrophoresis Device by Huang, Ying, Yang, Joon Mo, Hopkins, Penelope J, Kassegne, Sam, Tirado, Marcus, ster, Anita H, Reese, Howard

“…Separation of simulants of biological warfare agents from blood using dielectrophoresis (DEP) was demonstrated in a miniaturized DEP device. The device was…”
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Use of wild-type p53 to achieve complete treatment sensitization of tumor cells expressing endogenous mutant p53 by Gjerset, R A, Turla, S T, Sobol, R E, Scalise, J J, Mercola, D, Collins, H, Hopkins, P J

“…It is known that transfer of the wild-type p53 gene into p53-negative cells from transgenic mice increases their sensitivity to drug and radiation-induced…”
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Mutation Creates an Open Reading Frame Within the 5' Untranslated Region of Macaque Erythrocyte Carbonic Anhydrase (CA) I mRNA That Suppresses CA I Expression and Supports the Scanning Model for Translation by Nils C. H. Bergenhem, Venta, Patrick J., Hopkins, Penelope J., Kim, Hyung J., Tashian, Richard E.

“…A variant allele at the CA I locus that produces a deficiency of erythrocyte-specific CA I occurs as a widespread polymorphism in pigtail macaques from…”
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Linkage Disequilibrium and Allele-Frequency Distributions for 114 Single-Nucleotide Polymorphisms in Five Populations by Goddard, Katrina A.B., Hopkins, Penelope J., Hall, Jeff M., Witte, John S.

“…Single-nucleotide polymorphisms (SNPs) may be extremely important for deciphering the impact of genetic variation on complex human diseases. The ultimate value…”
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A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease by Görlach, A, Lee, P L, Roesler, J, Hopkins, P J, Christensen, B, Green, E D, Chanock, S J, Curnutte, J T

“…The predominant genetic defect causing p47-phox-deficient chronic granulomatous disease (A47 degrees CGD) is a GT deletion (DeltaGT) at the beginning of exon…”
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Linkage of Bipolar Affective Disorder to Chromosome 18 Markers in a New Pedigree Series by McMahon, Francis J., Hopkins, Penelope J., Xu, Jianfeng, McInnis, Melvin G., Shaw, Sarah, Cardon, Lon, Simpson, Sylvia G., MacKinnon, Dean F., Stine, O. Colin, Sherrington, Robin, Meyers, Deborah A., DePaulo, J. Raymond

“…Several groups have reported evidence suggesting linkage of bipolar affective disorder (BPAD) to chromosome 18. We have reported data from 28 pedigrees that…”
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Relation between tumour necrosis factor polymorphism TNF[alpha]-308 and risk of asthma by Witte, John S, Palmer, Lyle J, O'Connor, Richard D, Hopkins, Penelope J, Hall, Jeff M

“…Tumour necrosis factor (TNF) alpha affects immune response and airway inflammation, which are characteristics of asthma. Genetic factors may impact TNFalpha…”
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Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma by Witte, John S, Palmer, Lyle J, O'Connor, Richard D, Hopkins, Penelope J, Hall, Jeff M

“…Tumour necrosis factor (TNF) alpha affects immune response and airway inflammation, which are characteristics of asthma. Genetic factors may impact TNFalpha…”
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Relation between tumour necrosis factor polymorphism TNFa-308 and risk of asthma by Witte, John S, Palmer, Lyle J, O'Connor, Richard D, Hopkins, Penelope J, Hall, Jeff M

“…Tumour necrosis factor (TNF) alpha affects immune response and airway inflammation, which are characteristics of asthma. Genetic factors may impact TNFa…”
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Mutations in the promoter region of the gene for gp91-phox in X-linked chronic granulomatous disease with decreased expression of cytochrome b558 by Newburger, P E, Skalnik, D G, Hopkins, P J, Eklund, E A, Curnutte, J T

“…We examined the molecular defect in two kindreds with "variant" X-linked chronic granulomatous disease (CGD). Western blots of neutrophil extracts showed…”
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Studying X inactivation by Curnutte, J T, Hopkins, P J, Kuhl, W, Beutler, E

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Origins and molecular evolution of the carbonic anhydrase isozymes by Hewett-Emmett, D, Hopkins, P J, Tashian, R E, Czelusniak, J

“…Work on membrane-bound and subcellular forms of CA at the protein level, and the possibility of multiple forms of the mouse CA II gene at the DNA level,…”
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Characterization of the gene encoding carbonic anhydrase I from the pigtail macaque by Hopkins, Penelope J., Bergenhem, Nils C.H., Venta, Patrick J., Hewett-Emmett, David, Tashian, Richard E.

“…The structure of the gene encoding carbonic anhydrase I (CA I) was determined for the pigtail macaque Macaca nemestrina. When the deduced amino-acid sequence…”
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Variation in coding exons of two electrophoretic alleles at the pigtail macaque carbonic anhydrase I locus as determined by direct, double-stranded sequencing of polymerase chain reaction (PCR) products by Bergenhem, Nils C. H., Venta, Patrick J., Hopkins, Penelope J., Tashian, Richard E.

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Chronic granulomatous disease: diagnosis and classification at the molecular level by Hopkins, P J, Bemiller, L S, Curnutte, J T

“…Chronic granulomatous disease (CGD) is caused by the failure of phagocytes to produce microbicidal derivatives of molecular oxygen, such as hydrogen peroxide…”
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