Search Results - "Hopfner, Karl–Peter"

Molecular mechanisms and cellular functions of cGAS–STING signalling by Hopfner, Karl-Peter, Hornung, Veit

“…The cGAS–STING signalling axis, comprising the synthase for the second messenger cyclic GMP–AMP (cGAS) and the cyclic GMP–AMP receptor stimulator of interferon…”
Get full text

Species-specific detection of the antiviral small-molecule compound CMA by STING by Cavlar, Taner, Deimling, Tobias, Ablasser, Andrea, Hopfner, Karl-Peter, Hornung, Veit

“…Extensive research on antiviral small molecules starting in the early 1970s has led to the identification of 10‐carboxymethyl‐9‐acridanone (CMA) as a potent…”
Get full text

Invited review: Architectures and mechanisms of ATP binding cassette proteins by Hopfner, Karl‐Peter

“…ABSTRACT ATP binding cassette (ABC) ATPases form chemo‐mechanical engines and switches that function in a broad range of biological processes. Most…”
Get full text

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors by Lässig, Charlotte, Hopfner, Karl-Peter

“…RIG-I-like receptors (RLRs) are cytosolic innate immune sensors that detect pathogenic RNA and induce a systemic antiviral response. During the last decade,…”
Get full text

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids by Hornung, Veit, Hartmann, Rune, Ablasser, Andrea, Hopfner, Karl-Peter

“…The presence of nucleic acids in the cytosol alerts the cell to viral infection or damaged self. The oligoadenylate synthase (OAS) proteins and cyclic GMP–AMP…”
Get full text

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis by Mankan, Arun K, Schmidt, Tobias, Chauhan, Dhruv, Goldeck, Marion, Höning, Klara, Gaidt, Moritz, Kubarenko, Andrew V, Andreeva, Liudmila, Hopfner, Karl-Peter, Hornung, Veit

“…Intracellular recognition of non‐self and also self‐nucleic acids can result in the initiation of potent pro‐inflammatory and antiviral cytokine responses…”
Get full text

Nuclear cGAS: guard or prisoner? by de Oliveira Mann, Carina C, Hopfner, Karl‐Peter

“…cGAS, an innate immune sensor of cellular stress, recognizes double‐stranded DNA mislocalized in the cytosol upon infection, mitochondrial stress, DNA damage,…”
Get full text

Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50 by Seifert, Florian Ulrich, Lammens, Katja, Stoehr, Gabriele, Kessler, Brigitte, Hopfner, Karl-Peter

“…The Mre11–Rad50–Nbs1 (MRN) complex is a central factor in the repair of DNA double‐strand breaks (DSBs). The ATP‐dependent mechanisms of how MRN detects and…”
Get full text

Structural mechanism of cytosolic DNA sensing by cGAS by Civril, Filiz, Deimling, Tobias, de Oliveira Mann, Carina C., Ablasser, Andrea, Moldt, Manuela, Witte, Gregor, Hornung, Veit, Hopfner, Karl-Peter

“…Cytosolic DNA arising from intracellular bacterial or viral infections is a powerful pathogen-associated molecular pattern (PAMP) that leads to innate immune…”
Get full text

Structural and biochemical characterization of human Schlafen 5 by Metzner, Felix J, Huber, Elisabeth, Hopfner, Karl-Peter, Lammens, Katja

“…Abstract The Schlafen family belongs to the interferon-stimulated genes and its members are involved in cell cycle regulation, T cell quiescence, inhibition of…”
Get full text

Ruler elements in chromatin remodelers set nucleosome array spacing and phasing by Oberbeckmann, Elisa, Niebauer, Vanessa, Watanabe, Shinya, Farnung, Lucas, Moldt, Manuela, Schmid, Andrea, Cramer, Patrick, Peterson, Craig L., Eustermann, Sebastian, Hopfner, Karl-Peter, Korber, Philipp

“…Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by alignment to reference sites like active promoters. How the distances between…”
Get full text

Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex by Käshammer, Lisa, Saathoff, Jan-Hinnerk, Lammens, Katja, Gut, Fabian, Bartho, Joseph, Alt, Aaron, Kessler, Brigitte, Hopfner, Karl-Peter

“…DNA double-strand breaks (DSBs) threaten genome stability throughout life and are linked to tumorigenesis in humans. To initiate DSB repair by end joining or…”
Get full text

Novel Poxin Stable cGAMP‐Derivatives Are Remarkable STING Agonists by Stazzoni, Samuele, Böhmer, Daniel F. R., Hernichel, Fabian, Özdemir, Dilara, Pappa, Aikaterini, Drexler, David, Bauernfried, Stefan, Witte, Gregor, Wagner, Mirko, Veth, Simon, Hopfner, Karl‐Peter, Hornung, Veit, König, Lars M., Carell, Thomas

“…2′,3′‐cGAMP is a cyclic A‐ and G‐containing dinucleotide second messenger, which is formed upon cellular recognition of foreign cytosolic DNA as part of the…”
Get full text

Genome information processing by the INO80 chromatin remodeler positions nucleosomes by Oberbeckmann, Elisa, Krietenstein, Nils, Niebauer, Vanessa, Wang, Yingfei, Schall, Kevin, Moldt, Manuela, Straub, Tobias, Rohs, Remo, Hopfner, Karl-Peter, Korber, Philipp, Eustermann, Sebastian

“…The fundamental molecular determinants by which ATP-dependent chromatin remodelers organize nucleosomes across eukaryotic genomes remain largely elusive. Here,…”
Get full text

Measuring DNA mechanics on the genome scale by Basu, Aakash, Bobrovnikov, Dmitriy G., Qureshi, Zan, Kayikcioglu, Tunc, Ngo, Thuy T. M., Ranjan, Anand, Eustermann, Sebastian, Cieza, Basilio, Morgan, Michael T., Hejna, Miroslav, Rube, H. Tomas, Hopfner, Karl-Peter, Wolberger, Cynthia, Song, Jun S., Ha, Taekjip

“…Mechanical deformations of DNA such as bending are ubiquitous and have been implicated in diverse cellular functions 1 . However, the lack of high-throughput…”
Get full text

Mechanistic understanding of human SLFN11 by Metzner, Felix J., Wenzl, Simon J., Kugler, Michael, Krebs, Stefan, Hopfner, Karl-Peter, Lammens, Katja

“…Schlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA endoribonuclease and DNA binding functions. It is recruited to stalled…”
Get full text

Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates by Witte, Gregor, Hartung, Sophia, Büttner, Katharina, Hopfner, Karl-Peter

“…To reveal mechanisms of DNA damage checkpoint initiation, we structurally and biochemically analyzed DisA, a protein that controls a Bacillus subtilis…”
Get full text

Hexasome-INO80 complex reveals structural basis of noncanonical nucleosome remodeling by Zhang, Min, Jungblut, Anna, Kunert, Franziska, Hauptmann, Luis, Hoffmann, Thomas, Kolesnikova, Olga, Metzner, Felix, Moldt, Manuela, Weis, Felix, DiMaio, Frank, Hopfner, Karl-Peter, Eustermann, Sebastian

“…Loss of H2A-H2B histone dimers is a hallmark of actively transcribed genes, but how the cellular machinery functions in the context of noncanonical nucleosomal…”
Get full text

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA by Herzner, Anna-Maria, Hagmann, Cristina Amparo, Goldeck, Marion, Wolter, Steven, Kübler, Kirsten, Wittmann, Sabine, Gramberg, Thomas, Andreeva, Liudmila, Hopfner, Karl-Peter, Mertens, Christina, Zillinger, Thomas, Jin, Tengchuan, Xiao, Tsan Sam, Bartok, Eva, Coch, Christoph, Ackermann, Damian, Hornung, Veit, Ludwig, Janos, Barchet, Winfried, Hartmann, Gunther, Schlee, Martin

“…Truncated reverse transcription of HIV RNA produces a single-stranded DNA intermediate with a unique Y-DNA stem-loop structure flanked by unpaired guanines…”
Get full text

c-di-AMP recognition by Staphylococcus aureus PstA by Müller, Martina, Hopfner, Karl-Peter, Witte, Gregor

“…•We solved the crystal structure of S. aureus PstA with and without c-di-AMP.•PstA has a ferredoxin-like fold similar to PII-proteins.•PstA has a different…”
Get full text