Search Results - "Hopewell, Jemma .C"

The role of lipoprotein (a) in chronic kidney disease by Hopewell, Jemma C., Haynes, Richard, Baigent, Colin

“…Lipoprotein (a) [Lp(a)] and its measurement, structure and function, the impact of ethnicity and environmental factors, epidemiological and genetic…”
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Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data by Oikonomou, Evangelos K, Marwan, Mohamed, Desai, Milind Y, Mancio, Jennifer, Alashi, Alaa, Hutt Centeno, Erika, Thomas, Sheena, Herdman, Laura, Kotanidis, Christos P, Thomas, Katharine E, Griffin, Brian P, Flamm, Scott D, Antonopoulos, Alexios S, Shirodaria, Cheerag, Sabharwal, Nikant, Deanfield, John, Neubauer, Stefan, Hopewell, Jemma C, Channon, Keith M, Achenbach, Stephan, Antoniades, Charalambos

“…Coronary artery inflammation inhibits adipogenesis in adjacent perivascular fat. A novel imaging biomarker—the perivascular fat attenuation index…”
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Genetic determinants of blood lipids and cerebral small vessel disease: role of high-density lipoprotein cholesterol by Georgakis, Marios K, Malik, Rainer, Anderson, Christopher D, Parhofer, Klaus G, Hopewell, Jemma C, Dichgans, Martin

“…Blood lipids are causally involved in the pathogenesis of atherosclerosis, but their role in cerebral small vessel disease remains largely elusive. Here, we…”
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Differential effects of PCSK9 variants on risk of coronary disease and ischaemic stroke by Hopewell, Jemma C, Malik, Rainer, Valdés-Márquez, Elsa, Worrall, Bradford B, Collins, Rory

“…Abstract Aims PCSK9 genetic variants that have large effects on low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) have prompted the…”
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Lipids and lipoproteins and risk of different vascular events in the MRC/BHF Heart Protection Study by Parish, Sarah, Offer, Alison, Clarke, Robert, Hopewell, Jemma C, Hill, Michael R, Otvos, James D, Armitage, Jane, Collins, Rory

“…Low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are established risk factors for vascular disease, but lipoprotein…”
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Genetic associations of adult height with risk of cardioembolic and other subtypes of ischemic stroke: A mendelian randomization study in multiple ancestries by Linden, Andrew B, Clarke, Robert, Hammami, Imen, Hopewell, Jemma C, Guo, Yu, Whiteley, William N, Lin, Kuang, Turnbull, Iain, Chen, Yiping, Yu, Canqing, Lv, Jun, Offer, Alison, Bennett, Derrick, Walters, Robin G, Li, Liming, Chen, Zhengming, Parish, Sarah

“…Taller adult height is associated with lower risks of ischemic heart disease in mendelian randomization (MR) studies, but little is known about the causal…”
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Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study by Hopewell, Jemma C, Parish, Sarah, Offer, Alison, Link, Emma, Clarke, Robert, Lathrop, Mark, Armitage, Jane, Collins, Rory

“…Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncertain whether there is clinically relevant genetic variation in…”
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Impact of Apolipoprotein(a) Isoform Size on Lipoprotein(a) Lowering in the HPS2-THRIVE Study by Parish, Sarah, Hopewell, Jemma C, Hill, Michael R, Marcovina, Santica, Valdes-Marquez, Elsa, Haynes, Richard, Offer, Alison, Pedersen, Terje R, Baigent, Colin, Collins, Rory, Landray, Martin, Armitage, Jane

“…Genetic studies have shown lipoprotein(a) (Lp[a]) to be an important causal risk factor for coronary disease. Apolipoprotein(a) isoform size is the chief…”
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Assessment of the causal relevance of ECG parameters for risk of atrial fibrillation: A mendelian randomisation study by Gajendragadkar, Parag Ravindra, Von Ende, Adam, Ibrahim, Maysson, Valdes-Marquez, Elsa, Camm, Christian Fielder, Murgia, Federico, Stiby, Alexander, Casadei, Barbara, Hopewell, Jemma C

“…Atrial electrical and structural remodelling in older individuals with cardiovascular risk factors has been associated with changes in surface…”
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Identifying systematic heterogeneity patterns in genetic association meta-analysis studies by Magosi, Lerato E, Goel, Anuj, Hopewell, Jemma C, Farrall, Martin

“…Progress in mapping loci associated with common complex diseases or quantitative inherited traits has been expedited by large-scale meta-analyses combining…”
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Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis by Chasman, Daniel I, Paré, Guillaume, Mora, Samia, Hopewell, Jemma C, Peloso, Gina, Clarke, Robert, Cupples, L Adrienne, Hamsten, Anders, Kathiresan, Sekar, Mälarstig, Anders, Ordovas, José M, Ripatti, Samuli, Parker, Alex N, Miletich, Joseph P, Ridker, Paul M

“…While conventional LDL-C, HDL-C, and triglyceride measurements reflect aggregate properties of plasma lipoprotein fractions, NMR-based measurements more…”
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Impact of New Cardiovascular Events on Quality of Life and Hospital Costs in People With Cardiovascular Disease in the United Kingdom and United States by Lui, Juliana Nga Man, Williams, Claire, Keng, Mi Jun, Hopewell, Jemma C, Sammons, Emily, Chen, Fang, Gray, Alastair, Bowman, Louise, Landray, Sir Martin J, Mihaylova, Borislava

“…Despite optimized risk factor control, people with prior cardiovascular disease remain at high cardiovascular disease risk. We assess the immediate- and…”
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Lack of genetic support for shared aetiology of Coronary Artery Disease and Late-onset Alzheimer’s disease by Grace, Christopher, Clarke, Robert, Goel, Anuj, Farrall, Martin, Watkins, Hugh, Hopewell, Jemma C.

“…Epidemiological studies suggest a positive association between coronary artery disease (CAD) and late-onset Alzheimer’s disease (LOAD). This large-scale…”
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No Impact of KIF6 Genotype on Vascular Risk and Statin Response Among 18,348 Randomized Patients in the Heart Protection Study by Hopewell, Jemma C., PhD, Parish, Sarah, DPhil, Clarke, Robert, MD, Armitage, Jane, MB, BS, Bowman, Louise, MD, Hager, Jorg, PhD, Lathrop, Mark, PhD, Collins, Rory, FMedSci

“…Objectives The aim of this study was to test the effects of the KIF6 Trp719Arg polymorphism (rs20455) on vascular risk and response to statin therapy in 18,348…”
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Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients by Landray, Martin J, Haynes, Richard, Hopewell, Jemma C, Parish, Sarah, Aung, Theingi, Tomson, Joseph, Wallendszus, Karl, Craig, Martin, Jiang, Lixin, Collins, Rory, Armitage, Jane

“…Adults with vascular disease were treated with a statin to lower LDL cholesterol and were assigned to receive either extended-release niacin plus laropiprant…”
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Smoking and COVID-19 outcomes: an observational and Mendelian randomisation study using the UK Biobank cohort by Clift, Ashley K, von Ende, Adam, Tan, Pui San, Sallis, Hannah M, Lindson, Nicola, Coupland, Carol A C, Munafò, Marcus R, Aveyard, Paul, Hippisley-Cox, Julia, Hopewell, Jemma C

“…Conflicting evidence has emerged regarding the relevance of smoking on risk of COVID-19 and its severity. We undertook large-scale observational and Mendelian…”
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Lp(a) (Lipoprotein[a]), an Exemplar for Precision Medicine: Insights From UK Biobank by Hopewell, Jemma C., Clarke, Robert, Watkins, Hugh

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Mendelian randomization with fine‐mapped genetic data: Choosing from large numbers of correlated instrumental variables by Burgess, Stephen, Zuber, Verena, Valdes‐Marquez, Elsa, Sun, Benjamin B, Hopewell, Jemma C

“…ABSTRACT Mendelian randomization uses genetic variants to make causal inferences about the effect of a risk factor on an outcome. With fine‐mapped genetic…”
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Proteomic profiling identifies novel independent relationships between inflammatory proteins and myocardial infarction by Valdes-Marquez, Elsa, Clarke, Robert, Hill, Michael, Watkins, Hugh, Hopewell, Jemma C

“…Abstract Background Inflammation has been implicated in the pathogenesis of coronary heart disease, but the relevance and independence of individual…”
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Genetically Determined Levels of Circulating Cytokines and Risk of Stroke: Role of Monocyte Chemoattractant Protein-1 by Georgakis, Marios K, Gill, Dipender, Rannikmäe, Kristiina, Traylor, Matthew, Anderson, Christopher D, Lee, Jin-Moo, Kamatani, Yoichiro, Hopewell, Jemma C, Worrall, Bradford B, Bernhagen, Jürgen, Sudlow, Cathie L M, Malik, Rainer, Dichgans, Martin

“…BACKGROUND:Cytokines and growth factors have been implicated in the initiation and propagation of vascular disease. Observational studies have shown…”
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