Search Results - "Hooshdaran, Nima"
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p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis
Published in Molecular cell (20-02-2020)“…The tumor suppressor p53 transcriptionally activates target genes to suppress cellular proliferation during stress. p53 has also been implicated in the…”
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CUB Domain-Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration-Resistant Prostate Cancer, including PSMA Null Disease
Published in Clinical cancer research (15-07-2022)“…With the improvement in overall survival with 177Lu-PSMA 617, radioligand therapy (RLT) is now a viable option for patients with metastatic…”
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Temporal Control of the TGF-β Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities
Published in Cell reports (Cambridge) (26-11-2019)“…Although microRNAs (miRNAs) function in the control of embryonic stem cell (ESC) pluripotency, a systems-level understanding is still being developed. Through…”
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Elevated labile iron in castration–resistant prostate cancer is targetable with ferrous iron–activatable antiandrogen therapy
Published in European journal of medicinal chemistry (05-03-2023)“…Clinical responses to second generation androgen signaling inhibitors (e.g., enzalutamide) in metastatic castration-resistant prostate cancer (mCRPC) are…”
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Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies
Published in Journal of Nuclear Medicine (01-07-2021)“…Although cancer has been known for decades to harbor an insatiable appetite for iron, only recently has the chemistry emerged to exploit this altered state…”
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In Vivo Profiling with 18F‑YJH08 Reveals Diverse Tissue Patterns of Antagonist/Glucocorticoid Receptor Interactions
Published in Molecular pharmaceutics (07-02-2022)“…Demonstrating target engagement in vivo is an important milestone in drug development, both to establish on target, on tissue interactions but also to identify…”
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In Vivo Profiling with 18 F-YJH08 Reveals Diverse Tissue Patterns of Antagonist/Glucocorticoid Receptor Interactions
Published in Molecular pharmaceutics (07-02-2022)“…Demonstrating target engagement in vivo is an important milestone in drug development, both to establish on target, on tissue interactions but also to identify…”
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Theranostic Targeting of CUB Domain-Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer
Published in Clinical cancer research (03-04-2023)“…Despite recent approvals for checkpoint inhibitors and antibody-drug conjugates targeting NECTIN4 or TROP2, metastatic bladder cancer remains incurable and new…”
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